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Medicine Research ›› 2017, Vol. 1 ›› Issue (1): 20-24.DOI: 10.21127/yaoyimr20170004

• Minireview • Previous Articles    

Biosynthetic Pathways and Bioactivities of Bisindole Compounds:a Short Review

Qian Shiyuna,Guo Ruihuaa,Dong Duana,Bao Binab,Wang Shujunc,Wu Wenhuiab*   

  1. a Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University,Shanghai 201306, China
    b Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China;
    c Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Huaihai Institute of Technology, Lianyungang,Jiangsu 222005, China
  • Received:2017-07-31 Accepted:2017-08-04 Online:2017-08-08 Published:2017-08-07
  • Contact: Qian Shiyun,Guo Ruihua,Wu Wenhui
  • Supported by:


A lot ofindole compounds possessing complex structures exist widely in alkaloids with enormous research significance. Specifically, bisindoles play a great role in the treatment of cancer, tumors, cardiovascular and cerebrovascular diseases. Many researchers are devoted to their biosynthesis. The structural diversity of bisindoles is attributed to multiple active sites of tryptophan. They presented bioactivities against anti-inflammatory, anti-bacterial, anti-virus and anti-cancer properties at the C-3 site of bisindoles. This paper reviews recent advances on biosynthesis pathways and bioactivites of bisindoles.


Key words: bisindoles, biosynthesis pathways, bioactivities

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