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Medicine Research ›› 2018, Vol. 2 ›› Issue (1): 170019-3.DOI: 10.21127/yaoyimr20170019

Special Issue: Phytomedicine

• Minireview • Previous Articles     Next Articles

Plant-Derived Kavalactones and Their Bioactivities

Nenling Zhanga,b, Linjing Wua,b, Xiang Liua,b, Xiangchun Shena,b,*()   

  1. a The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability, Guizhou Medical University, Guiyang, Guizhou 550025, China
    b The Union Key Laboratory of Guiyang City & Guizhou Medical University, Guiyang, Guizhou 550025, China
  • Received:2018-02-05 Accepted:2018-03-19 Online:2018-03-25 Published:2018-03-25
  • Contact: Xiangchun Shen


Kavalactones, mainly found in Piper methysticum, are a class of lactone compounds usually with an arylethylene-pyrone skeleton. Till now, fifty-one kavalactones have been isolated from the genera Piper, Alpinia, Amomum, Polygala, Goniothalamus, and Dumortiera. The bioactivities of six kavalactones, kawain, 7,8-dihydro- kawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyagonin, have been studied extensively. This review aims to give an overview of kavalactones in the plants and their various bioactivities.


Key words: kavalactone, Piper, Alpinia, bioactivities

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