Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview

doi:10.21127/yaoyimr20180009

Medicine Research ›› 2018, Vol. 2 ›› Issue (2): 180009-.DOI: 10.21127/yaoyimr20180009

Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview

Yue Zhao^a^b^c^e^†,Lijun Wang^a^b^e^†,Chuanlong Guo^a^b^d^e,Bo Jiang^a^b^e,Xiangqian Li^a^b^e,Kun Liu^c^*(),Dayong Shi^a^b^d^e^*()

^aKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong 266071, China
^b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266071, China
^c School of Pharmacy, Qingdao University, Qingdao 266071, China
^d University of Chinese Academy of Sciences, Beijing 100049, China
^e Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, Shandong 266071, China

Received:2018-08-03 Accepted:2018-08-10 Online:2018-06-30 Published:2018-09-01
Contact: Yue Zhao,Lijun Wang,Kun Liu,Dayong Shi

Abstract

Abstract:

As cancer is one of humanity’s biggest killers in the world, scientists have been looking for different drugs as agents to treat cancer. However, current chemotherapeutics is not sufficiently effective. Thiosemicarbazone complexes of transition metals have attracted wide attention due to a great effect of anticancer activity with different mechanisms including ribonucleotide reductase inhibition, metal dependent radical damage, DNA binding, and inhibition of protein synthesis, and so on. In this minireview, we summarize different metal chelators of thiosemicarbazones and their anticancer mechanisms, which are useful for the development of thiosemicarbazone as anticancer drugs.

Key words: thiosemicarbazones, metal chelators, anticancer activities

Yue Zhao, Lijun Wang, Chuanlong Guo, Bo Jiang, Xiangqian Li, Kun Liu, Dayong Shi. Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview[J]. Medicine Research, 2018, 2(2): 180009-.

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Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview

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