Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact Us
Early Edition  //  Current Issue  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited

Medicine Research ›› 2018, Vol. 2 ›› Issue (2): 180009-.DOI: 10.21127/yaoyimr20180009

Special Issue: Anticancer Agents

• Minireview • Previous Articles    

Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview

Yue Zhaoabce,Lijun Wangabe,Chuanlong Guoabde,Bo Jiangabe,Xiangqian Liabe,Kun Liuc*(),Dayong Shiabde*()   

  1. a Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong 266071, China
    b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, Shandong 266071, China
    c School of Pharmacy, Qingdao University, Qingdao 266071, China
    d University of Chinese Academy of Sciences, Beijing 100049, China
    e Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, Shandong 266071, China
  • Received:2018-08-03 Accepted:2018-08-10 Online:2018-06-30 Published:2018-09-01
  • Contact: Yue Zhao,Lijun Wang,Kun Liu,Dayong Shi


As cancer is one of humanity’s biggest killers in the world, scientists have been looking for different drugs as agents to treat cancer. However, current chemotherapeutics is not sufficiently effective. Thiosemicarbazone complexes of transition metals have attracted wide attention due to a great effect of anticancer activity with different mechanisms including ribonucleotide reductase inhibition, metal dependent radical damage, DNA binding, and inhibition of protein synthesis, and so on. In this minireview, we summarize different metal chelators of thiosemicarbazones and their anticancer mechanisms, which are useful for the development of thiosemicarbazone as anticancer drugs.


Key words: thiosemicarbazones, metal chelators, anticancer activities

Copyright © Medicine Research, All Rights Reserved.
Address: 425 East 76th Street, Apt 9E, New York, NY, 10021, United States