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Medicine Research ›› 2018, Vol. 2 ›› Issue (3): 180013-.DOI: 10.21127/yaoyimr20180013

• Minireview • Previous Articles     Next Articles

Molecular Structural Characteristic and Functional Performance of IgY Antibodies from Immunologic Chicken Egg

Wu Qiaoa, Wenhui Wua, b, c, *   

  1. a College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;
    b Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China;
    c National Experimental Teaching Demonstration Center for Food Science and Engineering (Shanghai Ocean University), Shanghai 201306, China
  • Received:2018-09-04 Revised:2018-09-09 Online:2018-11-24 Published:2018-11-24
  • About author:whwu@shou.edu.cn
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 81502955), the Doctoral Scientific Research Foundation of Shanghai Ocean University (No. A2030214300077), the Young Teachers’ Training Program of Shanghai (No. A12056160002), the Plan of Innovation Action in Shanghai (No. 14431906000), and the Project Funded by Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening.

Abstract: Chicken egg yolk immunoglobulin (IgY) extracted from chicken eggs by special pathogens stimulating chicken regularly is an effective antibody. IgY is similar to mammalian counterpart IgG, but it has its special structure, which influence its functional performance. Oral administration of specific antibodies is an effective approach against bacterial infection in humans and animals. Oral administration of IgY extracted from chicken eggs has many advantages compared with mammalian IgG including cost-effectiveness, convenience, high yield. Moreover, IgY has good stability in intestinal tract and it has safe profile. IgY is used as a novel mode of immunotherapy to confer passive immunity that has gained much attention as a non-antibiotic method to prevent and treat a wide variety of infectious diseases. This minireview presents an overview of the application of IgY for the treatment of dental caries, periodontitis, gastritis cancer and enteric infection. In addition, some limitations of IgY technology are also discussed.

 

Key words: immunoglobulin, IgY, molecular structural characteristic, functional performance

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