Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact Us
 
Early Edition  //  Current Issue  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Medicine Research
Reports |
Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin
Jun Zhu,‡,a Jiejun Cheng,‡,b Juan Zhou,a Gang Huang,*,c and Dannong He*,a,b
a National Engineering Research Center for Nanotechnology, 28 East Jiangchuan Road, Shanghai 200241, China
b Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Rd, Shanghai 200127, China
c Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China
Download: PDF(625 KB)  
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks     Supporting Info
Abstract  In this paper, the surface of ultra high molecular weight polyethylene (UHMWPE) scaffold is modified to improve the hydrophilicity and cell adhesion behavior with silk fibroin (SF) grafting. Fourier Transform Infrared Spectroscopy (FT-IR), scanning electron microscope (SEM), Thermogravimetric (TG) and water contact angle analysis are performed to characterize the chemical structure, hydrophilicity and the morphology of UHMWPE/SF composites. The results show that SF can coat on the surface of UHMWPE scaffold, and the chromic acid etching is more conducive to SF deposition. After chrome-acid etching, both of the hydrophilicity and SF deposition on the surface of UHMWPE scaffold are improved, and the coating amount of SF is 10.31%. Furthermore, there is no obvious decrease in mechanical properties, which proves that SF on the surface of UHMWPE scaffold has no effect on its mechanical properties. The cell adhesion experiments on UHMWPE scaffold are evaluated and the maximum cell viability appears in PECrSFs, which means that the biocompatibility is the best. All results have clearly indicated that the surface modification on UHMWPE scaffold with SF is an effective way of producing a suitably hydrophilic surface for their applications in biomedicine.
Keywords ultra high molecular weight polyethylene scaffold      silk fibroin      surface modification      biocompatibility     
Fund: 
Corresponding Authors: Gang Huang: huang2802@163.com (G. H.), Dannong He: hdn_nercn@163.com (D. H.)   
About author: These authors contributed equally to this work.
Online First Date: 18 July 2019   
0
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Jun Zhu
Jiejun Cheng
Juan Zhou
Gang Huang
Dannong He
Cite this article:   
Jun Zhu,Jiejun Cheng,Juan Zhou, et al. Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin[J]. Medicine Research, 18 July 2019. [Epub ahead of print] doi: 10.21127/yaoyimr20190006.
URL:  
http://www.medicineresearch.org/EN/10.21127/yaoyimr20190006    
[1] .  [J]. Medicine Research, 2019, 3(3): 0.
[2] Zhaokun Zhang, Yan Xu, Kunfeng Zhao, Ying Zhang, Weijia Chen, Xiaodi Li, Yanxia Meng, Dicheng Yang, Ping Wang, Jun Zhu. Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine[J]. Medicine Research, 2019, 3(3): 190008.
[3] Bailei Li, Wenhui Wu. Review on Adaptation between Biomaterials Function of Chitosan and Its Structure[J]. Medicine Research, 2019, 3(3): 190013.
[4] Quan Shen, Pengjie Tang, Ming Ma, Bin Bao. Insights into the Structure of Human Blood Coagulation Factor Ⅹ[J]. Medicine Research, 2019, 3(3): 190012.
[5] Fang Li, Tingyu Wen, Jifeng Liu. Progress in Chemical Constituents and Bioactivities of Broussonetia pa-pyrifera (L.) Vent[J]. Medicine Research, 2019, 3(2): 190005.
[6] . Xplorer Awards in Life Sciences[J]. Medicine Research, 2019, 3(2): 20196001.
[7] . Interview with Professor Nenling Zhang[J]. Medicine Research, 2019, 3(2): 198002.
[8] Jingjuan Li, Fucai Ren, Jiangmiao Hu. Progress of Picrotoxane Type Alkaloids in Dendrobium[J]. Medicine Research, 2019, 3(2): 190007.
[9] . Contents: Med. Res. 2/2019 [J]. Medicine Research, 2019, 3(2): 0.
[10] Medicine Research. Contents: Med. Res. 3/2018[J]. Medicine Research, 2018, 2(3): 0.
[11] Xianxian Miao, Wenhui Wu, Ming Ma, Bin Bao. Symbiotic Mechanism and Chemical Signaling Molecule of Marine Sponges[J]. Medicine Research, 2018, 2(3): 180010.
[12] Jingjing Chen, Wenhui Wu. What is Oral Tolerance?[J]. Medicine Research, 2018, 2(3): 180012.
[13] Qianqian Chu, Bin Bao, Wenhui Wu. Mechanism of Interaction between Phenolic Compounds and Proteins Based on Non-Covalent and Covalent Interactions[J]. Medicine Research, 2018, 2(3): 180014.
[14] Wu Qiao, Wenhui Wu. Molecular Structural Characteristic and Functional Performance of IgY Antibodies from Immunologic Chicken Egg[J]. Medicine Research, 2018, 2(3): 180013.
[15] Jiayu Xie, Lingling Wang, Wenhui Wu, Jie Ou. Recent Advances on Determination Methods of Mycotoxins and Marine Biotoxins[J]. Medicine Research, 2018, 2(3): 180011.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
沪ICP备15041762号-3
Copyright © Medicine Research, All Rights Reserved.
Address: 425 East 76th Street, Apt 9E, New York, NY, 10021, the United States