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Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin
Jun Zhu,‡,a Jiejun Cheng,‡,b Juan Zhou,a Gang Huang,*,c and Dannong He*,a,b
a National Engineering Research Center for Nanotechnology, 28 East Jiangchuan Road, Shanghai 200241, China
b Department of Radiology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, 1630 Dongfang Rd, Shanghai 200127, China
c Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Shanghai 201318, China
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Abstract  In this paper, the surface of ultra high molecular weight polyethylene (UHMWPE) scaffold is modified to improve the hydrophilicity and cell adhesion behavior with silk fibroin (SF) grafting. Fourier Transform Infrared Spectroscopy (FT-IR), scanning electron microscope (SEM), Thermogravimetric (TG) and water contact angle analysis are performed to characterize the chemical structure, hydrophilicity and the morphology of UHMWPE/SF composites. The results show that SF can coat on the surface of UHMWPE scaffold, and the chromic acid etching is more conducive to SF deposition. After chrome-acid etching, both of the hydrophilicity and SF deposition on the surface of UHMWPE scaffold are improved, and the coating amount of SF is 10.31%. Furthermore, there is no obvious decrease in mechanical properties, which proves that SF on the surface of UHMWPE scaffold has no effect on its mechanical properties. The cell adhesion experiments on UHMWPE scaffold are evaluated and the maximum cell viability appears in PECrSFs, which means that the biocompatibility is the best. All results have clearly indicated that the surface modification on UHMWPE scaffold with SF is an effective way of producing a suitably hydrophilic surface for their applications in biomedicine.
Keywords ultra high molecular weight polyethylene scaffold      silk fibroin      surface modification      biocompatibility     
Corresponding Authors: Gang Huang: (G. H.), Dannong He: (D. H.)   
About author: These authors contributed equally to this work.
Online First Date: 18 July 2019   
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Jun Zhu
Jiejun Cheng
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Jun Zhu,Jiejun Cheng,Juan Zhou, et al. Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin[J]. Medicine Research, 18 July 2019. [Epub ahead of print] doi: 10.21127/yaoyimr20190006.
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