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Medicine Research ›› 2017, Vol. 1 ›› Issue (1): 16-19.DOI: 10.21127/yaoyimr20170005

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Properties of Filaggrin Associating with Skin Barrier Structure in Moisture Retention

Yang Jingab,Wang Shujunb,Yang Weijiea,Yu Xiaoweic,Bao Binad*   

  1. a Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University,Shanghai 201306, China
    b Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Huaihai Institute of Technology,Lianyungang, Jiangsu 222005, China
    c Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233, China;
    d Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China;
  • Received:2017-07-28 Accepted:2017-08-04 Online:2017-08-08 Published:2017-08-07
  • Contact: Yang Jing,Wang Shujun,Bao Bin
  • Supported by:


The skin barrier is regulated by the stratum corneum and the tight junction located at the lamellar layer. Skin barrier can maintain the body’s moisture, prevent pathogens and allergens. Atopic dermatitis is caused by changes in the skin barrier associating with skin coloring. The main function of filaggrin is to maintain skin moisture. The level of filaggrin and its degradation products is affected not only by the genotype of filaggrin, but also by the inflammatory and exogenous stress factors. Regardless of the state of mutations in the filamentous protein, filaggrin deficiency was observed in patients with atopic dermatitis, indicating that the removal of polyphenol was a key factor in the pathogenesis of the skin disease. In this paper, we reviewed the function and morphological effects of filaggrin and its metabolites in the pathogenesis of atopic dermatitis. Filaggrin is considered as one of the most important proteins in the skin barrier.


Key words: filaggrin, keratinocyte, skin barrier, transepidermal water loss, cytokines

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