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Medicine Research ›› 2017, Vol. 1 ›› Issue (2): 38-41.DOI: 10.21127/yaoyimr20170016

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Development of Marine Fibrinolytic Enzymes as a Resource for Novel Proteases and Their Roles in Fibrinolysis and Thrombolysis

Ma Zibina,Ma Minga,Wu Wenhuiabc*   

  1. a College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
    b Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China;
    c National Experimental Teaching Demonstration Center for Food Science and Engineering, Shanghai Ocean University, Shanghai 201306, China
  • Received:2017-12-06 Accepted:2017-12-28 Online:2017-09-08 Published:2017-12-31
  • Contact: Wu Wenhui


Thrombosis is a serious disease of human health and life. Microorganism is an important source of fibrinolytic enzymes. The mechanism of action that it must combine with plasminogen to activate plasminogen of streptokinase is described. Herein, we summarize species characteristics and thrombolytic effects of fibrinolytic enzymes that are secreted from bacteria, actinomycetes and fungi. In recent years, more and more marine plasmin were found and used in thrombolytic test, displaying good fibrinolysis and thrombolysis.


Key words: microorganism, fibrinolytic enzyme, thrombolytic effect

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