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Medicine Research ›› 2020, Vol. 4 ›› Issue (4): 200018-200018.DOI: 10.21127/yaoyimr20200018

Special Issue: Phytomedicine

• Report • Previous Articles     Next Articles

Flavonoids, Phenylethanoids and Phenylpropanoids from Rhodiola rosea L. and Their Lipid-Lowering Activities on Receptor 5-HT2A

Hao Wang,a,b Ji-Lei Liang,a Qing-Ming He,a Guo-Hai Zhou,a Cun-Fu Li,a Ping-He Wei,a and Hao-Yan Dong*,a   

  1. a Jiangsu Key Laboratory of Chiral Pharmaceuticals Biosynthesis, Taizhou University, Taizhou, Jiangsu 225300, China
    b DICP-CMC Innovation Institute of Medicine, Taizhou, Jiangsu 225300, China
  • Received:2020-11-01 Revised:2020-12-12 Online:2020-12-20 Published:2020-12-20
  • Contact: donghaoyan2008@126.com (H. Y. D.)
  • Supported by:
     

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Abstract: Fifteen compounds, including 11 flavonoids, 2 phenylethanoids and 2 phenylpropanoids, were isolated from the roots of Rhodiola rosea L. Among them, quercetin (1) and quercetin-3-O-β-D-glucoside (2) were afforded from the genus Rhodiola for the first time. All isolates were evaluated for their agitating activities on receptor 5-HT2A and four compounds (12—15) showed obvious agitating activities, which were probably the main lipid-lowering active components of R. rosea L.

 

Key words: flavonoids, phenylpropanoids, phenylethanoids, Rhodiola rosea, lipid-lowering activity, receptor 5-HT2A

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