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Cover Illustration
2017, Vol.1  No.2
 The cover picture shows the bioactivities of Bulleyaconitine A and the relevant mechanisms, toxicities, as well as the metabolism. More details are discussed in the article by Guo and coworkers on page 35—37.

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  • Table of Content
      08 September 2017, Volume 1 Issue 2 Previous Issue    Next Issue
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    Contents: Med. Res. 2017, 1(2)
    Medicine Research. 2017, 1 (2): 1.  
    Abstract   PDF (391KB) ( )
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    Orginal Report
    A Simple Route for the Recovery of Cell and Organism Using Poly(lactic-co-glycolic acid)-Block-Polyethylene Glycol/Perfluoroctyl Bromide Emulsions through Pulmonary Administration
    Wang Jie, Li Niannian, Wang Ruochen, Huang Gang, Zhu Jun, He Dannong
    Medicine Research. 2017, 1 (2): 27.   DOI: 10.21127/yaoyimr20170008
    Abstract   HTML   PDF (733KB) ( )

    Poly(lactic-co-glycolic acid) (PLGA)-block-polyethylene glycol (PEG)/perfluoroctyl bromide (PFOB) emulsion, in which PLGA-block-PEG, as the carrier, is combined with perfluorocty bromide, is developed to improve arterial hypoxemia and ameliorate the lung ventilation through pulmonary drug delivery. The cell viability increased obviously, which shows that the emulsion has certain positive effects on the cell proliferation. Moreover, the emulsion can help cells quickly recover from the anoxic symptoms as indicated by cell hypoxia-reoxygenation experiment. When cells were incubated with the emulsion under hypoxia, an obvious increase of cell growth was observed, which indicated that the emulsion was capable of providing sufficient oxygen for cells. Then we established two different models of rabbits to investigate whether the PLGA-b-PEG/PFOB emulsion could improve lung ventilation of animals. The impressive result confirmed that the lung ventilation was ameliorated significantly after treatment of emulsion for a period of time. The histological assays further verified the emulsion had good biocompatibility. Furthermore, the concentration of HIF-1 alpha in tissues were evaluated by immunohistochemistry and western respectively to confirm the fact that the emulsion could significantly promote the expression of HIF-1 alpha in lung tissue cells which may have important contributions to tissue survival. In summary, the emulsion was confirmed to supply oxygen for cells and organisms to improve arterial hypoxemia, which reflects the tremendous potential application value in the field of alleviating hypoxemia in future.

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    Epidemiology of Hand, Foot, and Mouth Disease in Mainland China from 2011 to 2012
    Ding Guodong, Yu Jing, Qiao Jing
    Medicine Research. 2017, 1 (2): 32.   DOI: 10.21127/yaoyimr20170009
    Abstract   HTML   PDF (312KB) ( )

    Hand, foot, and mouth disease (HFMD) has become one of the most common infectious diseases in mainland China, with annual incidence rate up to 100 per 100,000. We analyzed data reported to surveillance systems at the Chinese Center for Disease Control and Prevention and described the epidemiological features of HFMD by age, seasonal, and geographic distribution from 2011 to 2012. The annual incidence rates of 2011 and 2012 were 120.8 and 161.0 per 100,000, respectively. Most HFMD cases (approximately 90%) were aged within 0-4 years old, while older children and adults were rarely affected. Seasonal variation in incidence was observed, with an incidence peak observed during May and June. The southeastern coastal areas of China display highest incidence rates of HFMD. HFMD is a common infectious disease in China and it has emerged as an important public concern causing extensive transmission in young children.

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    Activities of Naturally Occurring Alkaloids Bulleyaconitine A
    Shiyang Zhai,Wenjing Zhou,Yifan Xu,Xiaosu Wang,Xiao Ye,Shuyue Wang,Wenhui Wu,Ruihua Guo
    Medicine Research. 2017, 1 (2): 35.   DOI: 10.21127/yaoyimr20170010
    Abstract   HTML   PDF (300KB) ( )

    Bulleyaconitine A, a C19-diterpenoid alkaloid extracted from Aconitum bulleyanum Diels, showed various bioactivities, including anti-inflammatory, antinociceptivity, immunomodulatory effects as well as some toxicities. This paper reviewed the bioactivities of Bulleyaconitine A and the relevant mechanisms, toxicities, as well as the metabolism.

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    Development of Marine Fibrinolytic Enzymes as a Resource for Novel Proteases and Their Roles in Fibrinolysis and Thrombolysis
    Ma Zibin,Ma Ming,Wu Wenhui
    Medicine Research. 2017, 1 (2): 38.   DOI: 10.21127/yaoyimr20170016
    Abstract   HTML   PDF (206KB) ( )

    Thrombosis is a serious disease of human health and life. Microorganism is an important source of fibrinolytic enzymes. The mechanism of action that it must combine with plasminogen to activate plasminogen of streptokinase is described. Herein, we summarize species characteristics and thrombolytic effects of fibrinolytic enzymes that are secreted from bacteria, actinomycetes and fungi. In recent years, more and more marine plasmin were found and used in thrombolytic test, displaying good fibrinolysis and thrombolysis.

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    Orginal Report
    Graphene Oxide-Silica Composite Fillers into the Experimental Dental Adhesives for Potential Therapy
    Liu Mei, Hou Wei, Chen Wenjing, Hu Xiaokun
    Medicine Research. 2017, 1 (2): 42.   DOI: 10.21127/yaoyimr20170012
    Abstract   HTML   PDF (729KB) ( )

    The aim of this study was to investigate the benefits of incorporation of graphene oxide-silica (GO@SiO2) on the degree of conversion and bond strength of an experimental dental adhesive. The GO@SiO2 nanocomposites were prepared and characterized by using FTIR, Raman and TEM. After that, GO@SiO2 was added into an experimental dental bonding system as novel nanofiller, and the effect of the modification on the dispersion stability of the GO@SiO2 nanocomposites in the experimental adhesive was studied. In addition, the degree of conversion was characterized by real-time FTIR, and the light conversion kinetic curves were calculated. Furthermore, the bond strength of the experimental adhesive to dental restorative resin was investigated. The result showed that the GO@SiO2 nanocomposites dispersed well in the experimental adhesive, and the introduction of GO@SiO2 improved effectively the degree of conversion of the dental adhesive after curing. In addition, the experimental adhesive filled with GO@SiO2 nanocomposites showed not only similar bond strength to a commercial adhesive, but also enhanced dramatically compressive strength as well. Furthermore, the obtained experimental dental adhesives can increase reactive oxygen species level in cells through photothermal conversion to be used in potential therapy.

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