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Cover Illustration
2021, Vol.5  No.2
The cover picture shows that L-OHP induced T-ALLs cells death by blocking the PI3K/Akt signaling pathway to inhibit cell proliferation, increase intracellular calcium concentration and cellular promote ROS-mediated mitochondrial-dependent apoptosis.More details are discussed in the article by Cheng et al. on page 210003.

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  • Table of Content
      20 June 2021, Volume 5 Issue 2 Previous Issue    Next Issue
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    Chemical Constituents and Bioactivities of Aconitum episcopale
    Xiaojing Shen, Hong Wang, Jiao Cai, Zhubin Zhou, and Fanqiu Nie
    Medicine Research. 2021, 5 (2): 210001.   DOI: 10.21127/yaoyimr20210001
    Abstract   PDF (872KB) ( )
    Aconitum episcopale Levl., known as a characteristic Aconitum specie in China, is a perennial herbaceous plant classified into Aconitum L. (Ranunculaceae), which mainly distributes in northwest Yunnan and southwestern Sichuan. As a commonly traditional Chinese medicine, the root of A. episcopale has been used to treat anemofrigid-damp arthralgia, arthralgia, cold hernia and anesthesia analgesia with the effects of expelling wind and removing damness, warming menstruation and relieving pain. It also is used for solving other Aconitums poisoning in folk. In order to obtain more information for research and development of A. episcopale, the chemical components and pharmacological research on A. episcopale were reviewed. It is beneficial for future research, development and utilization of Aconitum and search for traditional herbal resources.
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    Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis
    Tao-Tao Xue, Hong-Bo Xu, Zhi-Shu Tang, Jin-Ao Duana, Hong-Bo Liu, Xin-Bo Shi, and Zhong-Xing Song
    Medicine Research. 2021, 5 (2): 210002.   DOI: 10.21127/yaoyimr20210002
    Abstract   PDF (717KB) ( )
    Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.
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    Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms
    Chunxia Gan, Chengting Zi, Jun Sheng, Xuanjun Wang, and Huanhuan Xu
    Medicine Research. 2021, 5 (2): 210006.  
    Abstract   PDF (629KB) ( )
    Skin is the largest human organ, which always suffered from environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin can take different protective mechanisms to maintain balance, excessive stresses can disrupt these systems, resulting in the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Phytochemicals are biologically active compounds derived from plants and herbal products, which appear to be beneficial in the battle against cancer as they exhibit anti-cancer effects and are inexpensive, widely available, and well tolerated. Studies have demonstrated that phytochemicals can act on various cellular processes including cell cycle, apoptosis and redox metastasis to inhibit the development and progression of skin cancer. This article mainly focuses on the progress in anti-skin cancer activity of phytochemicals and underlying molecular mechanisms, which will hopefully provide valuable insights into clinical applications of phytochemicals for treatment of skin cancers.
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    Flavonoids Isolated from the genus Ficus and Their Biological Activities
    Yaxian Zhao, Jing Niu, Qinru Zhou, Yan Chen, Shiquan Gan, Xiangchun Shen, Nenling Zhang
    Medicine Research. 2021, 5 (2): 210004.   DOI: 10.21127/yaoyimr20210004
    Abstract   PDF (2171KB) ( )
    There are about 1000 species in the genus Ficus and many can be used for medicinal purpose. The medicinal plants of this genus mainly contain terpenoids, flavonoids, alkaloids, and coumarins. In this paper, we summarized flavonoids isolated from the genus Ficus and their pharmacological effects including anti-bacterial, anti-inflammatory, antitumor, antioxidant, antiviral, protective activities on the cardiovascular system and other activities.
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    Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways
    Mengcheng Li, Yongpeng Wang, Lei Tian, Afsar Khan, Yudan Wang, Yaping Liu, Meilian Yang, Jianxin Cao, Guiguang Cheng, and Tianrui Zhao
    Medicine Research. 2021, 5 (2): 210003.   DOI: 10.21127/yaoyimr20210003
    Abstract   PDF (2460KB) ( )
    Oxaliplatin (L-OHP) is a new platinum anticancer drug, which is used for the treatment of metastatic colorectal cancer or the adjuvant treatment of stage III colon cancer. T-cell acute lymphoblastic leukemias (T-ALLs) are invasive thymocytic malignant tumors with poor prognosis. The purpose of this study was to evaluate the cytotoxic effect of L-OHP on human T-ALL cell lines MOLT-4, Jurkat, CCRF-CEM, and CEM/C1 cells. The CCK-8 method results showed that L-OHP significantly inhibited T-ALL cells proliferation. The inhibition of these T-ALL cells prolife by L-OHP seems to be related to the induction of cell cycle arrest. The effect of L-OHP on the cell cycle distribution of T-ALL cells varies with cell types. As to cells apoptosis, Annexin V/Propidium iodide assay disclosed that L-OHP prominently induced T-ALL cells apoptosis by activating the pathways of mitochondrial biogenesis and is more sensitive to MOLT-4 cells. Western blot analysis showed that L-OHP treatment could promote apoptosis through down-regulated Bcl-2 protein level, up-regulated Bax and caspase-9 proteins levels and cell cycle arrest by inhibiting the PI3K/Akt signaling pathway in MOLT-4 cells. Our results indicate that L-OHP, as a new type of platinum anticancer drug, may attract more attention in the future treatment of T-ALL.
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