Flavonnoids with Antithrombotic Activities: a Review

doi:10.21127/yaoyimr20170006

摘要/Abstract

Abstract:

Thrombus is a severe health problem all over the world, especially in developing countries. However, there is still no satisfactory antithrombotic therapeutic strategy. Currently, the clinical antithrombotic drugs suffer from several drawbacks such as high rate of bleedings and short half-life, causing allergic reactions or complications, etc. In recent years, small-molecule compounds isolated from natural products with antithrombotic activities become a hot issue in the field of drug research. In this review, we will focus on representative naturally occurring small molecule flavonoids with antithrombotic potency and potential for future therapeutic regimens to combat thrombosis disease.

Key words: thrombosis, small-molecule, antithrombotic activities, natural products, flavonoids

. [J]. Medicine Research, 2017, 1(1): 12-15.

Guo Ruihua,Duan Dong,Zhang Yiting,Fang Yiwen,Wu Wenhui. Flavonnoids with Antithrombotic Activities: a Review[J]. Medicine Research, 2017, 1(1): 12-15.

参考文献

[1]	Nicholson C. D.; Lensing A. W. Expert Opin. Investig. Drugs 2001, 10, 785.
[2]	Lee Y. K.; PlayerM. R. Med. Res. Rev. 2011, 31, 202.
[3]	Kong Y.; Wang Y.; Yang W.; Xie Z.; Li Z. J. Pharmacol. Sci. 2015, 127, 462.
[4]	Mohammad H.N.; Abbas, M.; Mohammad Reza, O. J. Hypertens. 2000, 18, 1705.
[5]	Smith S. C.; Rod J.; Pearson T. A.; Valentin F.; Salim Y.; Ole F.; Wood D. A.; Michael A.; John H.; Philip H. Circulation 2004, 109, 3112.
[6]	Mozaffarian D.; Benjamin E. J.; Go A. S.; Arnett D. K.; Blaha M. J.; Cushman M.; Das S. R.; de Ferranti, S.; Després, J. P.; Fullerton, H. J. Circulation 2016, 131, 29.
[7]	Beaglehole R.; Bonita R. Lancet 2008, 372, 1988.
[8]	Mathers C. D.; Dejan L. Plos Med. 2006, 3, 2011.
[9]	Ton L.; Kamphuisen P. W.; Northup P. G.; Porte R. J.. J. Hepatol. 2013, 59, 358.
[10]	Pranav S.; Bindra V. K.. Indian J Crit. Care Med. 2010, 14, 188.
[11]	Mega J. L.; Simon T. P. Lancet 2015, 386, 281.
[12]	Alessi M. C.; Juhan-Vague, I. La Revue Du Praticien 1999, 49, 1654.
[13]	Quinlan D. J.; Eriksson B. I. Best Pract. Res. Clin. Haematol. 2013, 26, 171.
[14]	Wei X.; Yin R. X.; Cardiology D. O. Med. Recapitulate 2014, 20, 4520.
[15]	Xavier A. R.; Siddiqui A. M.; Kirmani J. F.; Hanel R. A.; Yahia A. M.; Qureshi A. I. CNS Drugs 2003, 17, 213.
[16]	Gross P. L.; Weitz J. I. Clin. Pharmacol. Ther. 2009, 86, 139.
[17]	Johannes R.; Katus H. A. Expert Opin. Investig. Drugs 2003, 12, 781.
[18]	Hsieh F.; Hsu C.; Huang H.; Shiau C. FEBS J. 2005, 272, 407.
[19]	Balasubramaniam K.; Viswanathan G. N.; Marshall S. M.; Zaman A. G .Cardiol. Res. Pract.2012, 2012, 1.
[20]	Lees K. R.; Bluhmki E.; Kummer R. V.; Brott T. G.; Toni D.; Grotta J. C.; Albers G. W.; Kaste M.; Marler J. R.; Hamilton S. A. Lancet 2010, 375, 1695.
[21]	Peter S.; Wardlaw J. M.; Lindley R. I.; Martin D.; Geoff C.; Gordon M.; Karen I.; Graham V.; Anna C.; Adam K. Lancet 2012, 379, 2352.
[22]	Wardlaw J. M.; Murray V.; Berge E.; Zoppo G.; Sandercock P.; Lindley R. L.; Cohen G. Lancet 2012, 379, 2364.
[23]	Dawn K.; Lindsell C. J.; Lawrence B.; Walter K.; Broderick J. P. Stroke 2008, 39, 924.
[24]	Nadeau J. O.; Shi S. J.; Kapral M. K.; Richards J. A.; Silver F. L.; Hill M. D. Can. J. Neurol.Sci. 2005, 32, 433.
[25]	Arcelus J. I.; Pere D.; Del Carmen, F. C. M.; Ricardo, G.; David, J.; Sonia, J.; Lozano, F. S.; Manel, M.; Nieto, J. A.; Páramo, J. A. Clin. Appl. Thromb.-Hemost. 2014, 21, 297.
[26]	Friederich P. W.; Levi M.; Biemond B. J.; Charlton P.; Templeton D.; Zonneveld A. J.,Van; Bevan, P.; Pannekoek, H.; Cate, J. W. Circulation 1997, 96, 916.
[27]	Qiao J. X.; Wang T. C.; Réjean R.; Carl T.; Alexandre L. H.; Schumacher W. A.; Spronk S. A.; Sheldon H.; Gilles B.; John L. J. Med. Chem. 2013, 56, 9275.
[28]	Massimo C.; Savitri K.; Das C. M.; Reuben J. M.; William S.; Jamileh N.; Frederick B.; Gascoyne P. R.Circ. Res. 2012, 111, 920.
[29]	Louisa D.; Sim D. S.; Dilks J. R.; Price B.; Sarah B.; Denker B. M.; Georgios K.; Athan K.; Robert F. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 2951.
[30]	Bullingham A.; Strunin L. British J. Anaesthesia 2009, 339, 622.
[31]	Abboud M.; Needle S.; Burns-Kurtis, C.; Valocik, R. P.; Amour, A.; Chan, C.; Brown, D.; Chaudry, L.; Zhou, P.; Patikis, A. J. Cardiovascular Pharm. 2008, 52, 66.
[32]	Eriksson B. I.; Dahl O. E.; Lassen M. R.; Ward D. P.; Rothlein R.; Davis G.; Turpie A. G. G. J. Throm. Haemost. 2008, 6, 457.
[33]	Kolesnikov A.; Rai R.; Mordenti J.; Liu L.; Torkelson S.; Shrader W.; Leahy E.; Hu H.; Gjerstad E.; Janc J. Bioorg. Med. Chem. Lett. 2006, 16, 2243.
[34]	Srivastava S.; Goswami L. N.; Dikshit D. K .Med. Res. Rev.2005, 25, 66.
[35]	Rai R.; Kolesnikov A.; Yong L.; Young W. B.; Leahy E.; Sprengeler P. A.; Verner E.; Shrader W. D.; Burgess H. J.; Sangalang J. C. Bioorg. Med. Chem.Lett. 2001, 11, 1797.
[36]	Grover J. K.; Yadav S.; Vats V. J. Ethnopharmacol. 2002, 81, 81.
[37]	Hansen E.; Andersen J. H. Curr. Pharm. Biotechnol. 2015, 17, 71.
[38]	Orlikova B.; Legrand N.; Panning J.; Dicato M.; Diederich M. Cancer Treat. Res. 2014, 159, 123.
[39]	Sharma S. B.; Gupta R. Mini Rev. Med. Chem. 2015, 15, 52.
[40]	Tian L.; Teng X.; Zhong C. Gen.Chem. 2015, 1, 22.
[41]	Valko M.; Rhodes C. J.; Moncol J.; Izakovic M.; Mazur M. Chem. Biol. Interact. 2006, 160, 1.
[42]	Unnikrishnan M. K.; Veerapur V.; Nayak Y.; Mudgal P. P.; Mathew G. Polyphenols in Human Health & Disease 2013, 1, 143.
[43]	Fan L. L.; Zeng G. Y.; Zhou Y. P.; Zhang L. Y.; Cheng Y. S.Chin. Med. J. 1982, 95, 145.
[44]	Boyer J.; Liu R. H . Nutr. J.2004, 3, 1.
[45]	Rajput M. S.; Vineet M.; Purti A.; Chandrawanshi H. K.; Urmila P .Nat. Prod. Res.2011, 25, 1870.
[46]	Lin C. N.; Kuo S. H.; Chung M. I.; Ko F. N.; Teng C. M. J. Nat. Prod. 1997, 60, 851.
[47]	Afifi, F. U. Nat. Prod. Res. 2011, 26, 878.
[48]	Afifi F.; Shervington A.; Darwish R. Acta technologiae et legis medicamenti 1997, 8, 105.
[49]	Iizuka T.; Moriyama N. H.; Taniguchi A.; Hoshi K. Nat. Med. 2005, 59, 241.
[50]	Nian Y. Y.; Wei W. T.; Jin A. D. Nat. Prod. Res. 2010, 24, 1843.
[51]	Chaves D. S.; Frattani F. S.; Assafim M.; Almeida A.P.; Zingali R. B.; Costa S. S. Nat. Prod. Commun. 2011, 6, 961.
[52]	Beier R. C.; Ivie G. W.; Oertli E. H. Phytochemistry 1994, 36, 869.
[53]	Yoshikawa M.; Uemura T.; Shimoda H.; Kishi A.; Kawahara Y.; Matsuda H. Chem. Pharm. Bull. 2000, 48, 1039.
[54]	Ju S. D.; Oak P. Y.; Cheng G. Y.; Sung E. L.; Young H. P. Nat. Prod. Res. 2014, 28, 2312.
[55]	Lin C. N.; Wen L. S. Phytochemistry 1991, 30, 1669.
[56]	Shieh W. L.; Lin C. N. Phytochemistry 1992, 31, 364.
[57]	Chun N. L.; Wen L. S. Phytochemistry 1992, 31, 2922.
[58]	Lin C. N.; Shieh W. L.; Ko F. N.; Teng C. M. Biochem. Pharm. 1993, 45, 509.
[59]	Chun N. L.; Wen L. S. Phytochemistry 1992, 31, 2922.
[60]	Chen C. C.; Huang Y. L.; Sun C. M.; Shen C. C. J. Nat. Prod. 1996, 59, 412.
[61]	Kimura Y.; Okuda H.; Ogita Z. J. Nat. Prod. 1997, 60, 598.
[62]	Tsai W. J.; Hsin W. C.; Chen C. C. J. Nat. Prod. 1996, 59, 671.
[63]	Chen I. S.; Chen H. F.; Cheng M. J.; Chang Y. L.; Teng C. M.; Tsutomu I.; Chen J. J.; Tsai I. L.J. Nat. Prod. 2001, 64, 1143.