Controlled Imaging and Gene Transfection by Ultrasound Through a Positive Liposome

doi:10.21127/yaoyimr20180005

Medicine Research ›› 2018, Vol. 2 ›› Issue (2): 180005-.DOI: 10.21127/yaoyimr20180005

收稿日期:2018-06-20 接受日期:2018-07-02 出版日期:2018-06-30 发布日期:2018-09-01

Controlled Imaging and Gene Transfection by Ultrasound Through a Positive Liposome

Rui Liu^a,Xinyi Zhang^a^b,Dannong He^a^*()

^a National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
^b School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China

Received:2018-06-20 Accepted:2018-07-02 Online:2018-06-30 Published:2018-09-01
Contact: Dannong He

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Ultrasound-mediated gene delivery is a kind of new method of gene delivery because ultrasound given a certain dose of irradiation can reversibly change the morphology of the cell membrane. Thus, a gene carrier material is obtained through a positive liposome filled with CO₂ gas and absorbed by DNA molecule, in which ultrasound-mediated gene delivery is established. Furthermore, the kind of new method of gene delivery is helpful for the dissociation of DNA molecules from liposome (LIP)/DNA complex and the cellular membrane permeability, which can increase SPCA-1 cell viability. Furthermore, the transfection efficiencies of LIP/DNA complex to cells are performed and the effect of ultrasonic time and intensity is further estimated.

Key words: positive liposome, ultrasound, gene delivery, transfection efficiency

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. [J]. Medicine Research, 2018, 2(2): 180005-.

Rui Liu, Xinyi Zhang, Dannong He. Controlled Imaging and Gene Transfection by Ultrasound Through a Positive Liposome[J]. Medicine Research, 2018, 2(2): 180005-.

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Controlled Imaging and Gene Transfection by Ultrasound Through a Positive Liposome

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