Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

doi:10.21127/yaoyimr20200023

Medicine Research ›› 2021, Vol. 5 ›› Issue (1): 200023-200023.DOI: 10.21127/yaoyimr20200023

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

Zhao Wang,^a Filipe Olim,^b Jingjing Sun,^cAna Rute Neves,^b Fátima Mendes,^b Helena Tomás,^*,b and Ruilong Sheng^*,b

收稿日期:2020-12-22 修回日期:2021-01-31 出版日期:2021-01-20 发布日期:2021-01-20
基金资助:

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

Zhao Wang,^a Filipe Olim,^b Jingjing Sun,^cAna Rute Neves,^b Fátima Mendes,^b Helena Tomás,^*,b and Ruilong Sheng^*,b

^aSchool of Material Engineering, Jinling Institute of Technology, Nanjing, Jiangsu 211169, China
^b CQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
^c Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, United States

Received:2020-12-22 Revised:2021-01-31 Online:2021-01-20 Published:2021-01-20
Contact: ruilong.sheng@staff.uma.pt (R. S.)
Supported by:

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Abstract: Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox- dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.

Key words: polymers, doxorubicin, prodrug, stimuli-responsive, drug delivery, nanosystem

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Zhao Wang, Filipe Olim, Jingjing Sun, Ana Rute Neves, Fátima Mendes, Helena Tomás, and Ruilong Sheng. Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy[J]. Medicine Research, 2021, 5(1): 200023-200023.

[1]	Hao Wang, Ji-Lei Liang, Qing-Ming He, Guo-Hai Zhou, Cun-Fu Li, Ping-He Wei, and Hao-Yan Dong. Flavonoids, Phenylethanoids and Phenylpropanoids from Rhodiola rosea L. and Their Lipid-Lowering Activities on Receptor 5-HT_2A[J]. Medicine Research, 2020, 4(4): 200018-200018.
[2]	. Contents: Med. Res. 4/2020 [J]. Medicine Research, 2020, 4(4): 0-0.
[3]	. [J]. Medicine Research, 2020, 4(1-2): 209001-209001.
[4]	. Contents: Med. Res. 3/2019[J]. Medicine Research, 2019, 3(4): 0-0.
[5]	. 2019 Nobel Prize in Physiology or Medicine[J]. Medicine Research, 2019, 3(4): 196002-.
[6]	Chaoyan Zhang. Chaoyan Zhang[J]. Medicine Research, 2019, 3(4): 198003-.
[7]	. Contents: Med. Res. 3/2019[J]. Medicine Research, 2019, 3(3): 0-.
[8]	Jun Zhu, Jiejun Cheng, Juan Zhou, Gang Huang, Dannong He. Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin[J]. Medicine Research, 2019, 3(2): 190006-.
[9]	Jingjuan Li, Fucai Ren, Jiangmiao Hu. Progress of Picrotoxane Type Alkaloids in Dendrobium[J]. Medicine Research, 2019, 3(2): 190007-.
[10]	. Xplorer Awards in Life Sciences[J]. Medicine Research, 2019, 3(2): 20196001-.
[11]	. Interview with Professor Nenling Zhang[J]. Medicine Research, 2019, 3(2): 198002-.
[12]	. Contents: Med. Res. 2/2019 [J]. Medicine Research, 2019, 3(2): 0-.
[13]	Medicine Research. Contents: Med. Res. 3/2018[J]. Medicine Research, 2018, 2(3): 0-0.
[14]	. [J]. Medicine Research, 2018, 2(2): 180005-.
[15]	. Contents: Med. Res. 2/2018[J]. Medicine Research, 2018, 2(2): 180000-.

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

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