Medicine Research

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1. Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine

Zhaokun Zhang, Yan Xu, Kunfeng Zhao, Ying Zhang, Weijia Chen, Xiaodi Li, Yanxia Meng, Dicheng Yang, Ping Wang, Jun Zhu

Medicine Research 2019, 3 (3): 190008-0. DOI: 10.21127/yaoyimr20190008

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2. Mechanism of Interaction between Phenolic Compounds and Proteins Based on Non-Covalent and Covalent Interactions

Qianqian Chu, Bin Bao, Wenhui Wu

Medicine Research 2018, 2 (3): 180014-. DOI: 10.21127/yaoyimr20180014

摘要（842）

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Phenolic compounds are widely used in natural plant foods and have strong antioxidant properties, so they are widely used in food and medicine. The reaction between the phenolic compound and the protein can affect the functional properties of the protein, such as emulsifying properties, gel properties, solubility, thermal stability, and foaming properties. The mechanism of interaction between phenolic compounds and proteins are described from the aspects of non-covalent interaction and covalent interaction, and the characterization methods of the interaction mechanism between phenolic compounds and proteins are described. The indexes for characterizing the covalent bonding of phenolic compounds and proteins include the free amino group content, total sulfhydryl content, tryptophan content. Ninhydrin method, 2,4,6-trinitrobenzenesulfonic acid (TNBS) method, o-phthal- aldehyde (OPA) method and high-performance liquid phase chromatography were applied to o measure the free amino group content. Ellman’s method was applied to investigate total sulfhydryl content. Fluorescence measurements can be used for changes in tryptophan modification. The indexes for characterizing the con-covalent bonding of phenolic compounds and proteins include hydrogen bonding, hydrophobic interactions, disulfide bonds and hydrophobicity of protein surface. Hydrogen bonding, hydrophobic interactions and disulfide bonds can be investigated by Gómez-Guillén’s method. ANS fluorescent probe method was applied to measure the changes of hydrophobicity of protein surface.

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3. Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis

Tao-Tao Xue, Hong-Bo Xu, Zhi-Shu Tang, Jin-Ao Duana, Hong-Bo Liu, Xin-Bo Shi, and Zhong-Xing Song

Medicine Research 2021, 5 (2): 210002-210002. DOI: 10.21127/yaoyimr20210002

摘要（644）

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Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.

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4. Progress in Phytochemical and Bioactivities of Coffea arabica L.

Xiao-Jing Shen, Zhu-Bin Zhou, Fan-Qiu Nie, Cheng-Ting Zi, and Jiang-Ping Fan

Medicine Research 2020, 4 (3): 200012-. DOI: 10.21127/yaoyimr20200012

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Coffea arabica L. is a famous specie in genus caffee for medicinal treatment and diet with wide distribution and rich resources. It contains rich alkaloids, flavonoids and terpenes, which exhibited antioxidation, anti-inflammatory, antitumor, antidiabetic, live protection, and neuroprotective activities. Herein, we summarized the progress in the chemical constituents and bioactivities of C. arabica L. to provide ideas for medicinal development prospects of C. arabica L.

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5. Graphene Oxide-Silica Composite Fillers into the Experimental Dental Adhesives for Potential Therapy

Liu Mei, Hou Wei, Chen Wenjing, Hu Xiaokun

Medicine Research 2017, 1 (2): 42-46. DOI: 10.21127/yaoyimr20170012

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The aim of this study was to investigate the benefits of incorporation of graphene oxide-silica (GO@SiO₂) on the degree of conversion and bond strength of an experimental dental adhesive. The GO@SiO₂ nanocomposites were prepared and characterized by using FTIR, Raman and TEM. After that, GO@SiO₂ was added into an experimental dental bonding system as novel nanofiller, and the effect of the modification on the dispersion stability of the GO@SiO₂nanocomposites in the experimental adhesive was studied. In addition, the degree of conversion was characterized by real-time FTIR, and the light conversion kinetic curves were calculated. Furthermore, the bond strength of the experimental adhesive to dental restorative resin was investigated. The result showed that the GO@SiO₂ nanocomposites dispersed well in the experimental adhesive, and the introduction of GO@SiO₂ improved effectively the degree of conversion of the dental adhesive after curing. In addition, the experimental adhesive filled with GO@SiO₂ nanocomposites showed not only similar bond strength to a commercial adhesive, but also enhanced dramatically compressive strength as well. Furthermore, the obtained experimental dental adhesives can increase reactive oxygen species level in cells through photothermal conversion to be used in potential therapy.

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6. Recent Advances on Bioactivity of Seaweed Polysaccharides

Junwen Wang, Xueyan Li, Chaoyan Zhang

Medicine Research 2019, 3 (4): 200003-. DOI: 10.21127/yaoyimr20200003

摘要（529）

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Seaweed polysaccharide is an important active substance in seaweed with good gel property, stability, and film-forming properties. It possesses various biological activities such as anti-virus, anti-tumor, immune regulation, anti-oxidation, and is widely used in food, health care and cosmetics. This article reviews recent advances on biological activities of seaweed polysaccharides, with a view to better development and utilization of seaweed polysaccharides, and promoting the sustainable and healthy development of the seaweed polysaccharide industry.

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7. Recent Advances on anti-MRSA Natural Products Derived from Plants

Jing Guo, Xiaoyu Su, Tianfang Ma, Jifeng Liu

Medicine Research 2018, 2 (1): 170018-5. DOI: 10.21127/yaoyimr20170018

摘要（504）

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Methicillin-resistant Staphylococcus aureus (MRSA) is a multi-drug resistant pathogenic bacteria, which has seriously threatened human health for a long time. Therefore, there is an urgent and unmet demand for new types of antibiotics. In response to the antibiotic resistance, many researchers have studied natural products derived from plant for alternative antibiotics and therapies. In this review, we summarized recent advances on anti-MRSA natural products from plants and their potential antibacterial effect against MRSA as potential anti-MRSA agents since 2007.

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8. Flavonoids Isolated from the genus Ficus and Their Biological Activities

Yaxian Zhao, Jing Niu, Qinru Zhou, Yan Chen, Shiquan Gan, Xiangchun Shen, Nenling Zhang

Medicine Research 2021, 5 (2): 210004-210004. DOI: 10.21127/yaoyimr20210004

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There are about 1000 species in the genus Ficus and many can be used for medicinal purpose. The medicinal plants of this genus mainly contain terpenoids, flavonoids, alkaloids, and coumarins. In this paper, we summarized flavonoids isolated from the genus Ficus and their pharmacological effects including anti-bacterial, anti-inflammatory, antitumor, antioxidant, antiviral, protective activities on the cardiovascular system and other activities.

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9. Hydroxychloroquine for the Treatment of Coronavirus Disease 2019: Evidence, Possible Mode of Action and Industrial Supply

Mario Pagliaro, Francesco Meneguzzo

Medicine Research 2020, 4 (3): 200014-. DOI: 10.21127/yaoyimr20200014

摘要（440）

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Hydroxychloroquine, a known antiviral metabolite of chloroquine, is increasingly used along with antibiotic azithromycin for the treatment of COVID-19 infection. In about one month, India, the world’s largest manufacturer, delivered the pharmaceutical ingredient for treating COVID-19 to over 50 countries. Coupled to azithromycin, the therapy is being used across the world both for patients staying at home at the early phase of symptoms, as well as for patients hospitalized. We summarize achievements as of late April 2020, review possible modes of action and suggest avenues for the quick scale-up of production of hydroxychloroquine.

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10. Recent Advances on Small-Molecule Epidermal Growth Factor Receptor Inhibitors

Bo-Ya Shi, Ze-Hao Wang, Xuan-Jun Wang Jun Sheng, and Cheng-Ting Zi

Medicine Research 2020, 4 (3): 200011-. DOI: 10.21127/yaoyimr20200011

摘要（424）

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The epidermal growth factor receptor (EGFR) is a kind of cell membrane surface receptor with tyrosine kinase activity, which is closely related to the growth, proliferation, differentiation, apoptosis, metastasis and other processes of tumor cells. Targeting EGFR tyrosine kinase inhibitors has become a hot topic for drug development for treatment of non-small-cell cancer (NSCLC). Herein, we summarized recent advances on the targeted therapeutic drugs for NSCLC in recent years.

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11.

Wang Jie, Li Niannian, Wang Ruochen, Huang Gang, Zhu Jun, He Dannong

Medicine Research 2017, 1 (2): 27-31. DOI: 10.21127/yaoyimr20170008

摘要（408）

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12. Progress in Chemical Constituents and Pharmacological Effects of Lindera glauca

Jianchen Liu, Chunyan Du, Yanan Li, Shiman Zuo, Rui Tan, Hezhong Jiang

Medicine Research 2018, 2 (1): 180003-3. DOI: 10.21127/yaoyimr20180003

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13. Plant-Derived Kavalactones and Their Bioactivities

Nenling Zhang, Linjing Wu, Xiang Liu, Xiangchun Shen

Medicine Research 2018, 2 (1): 170019-3. DOI: 10.21127/yaoyimr20170019

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Kavalactones, mainly found in Piper methysticum, are a class of lactone compounds usually with an arylethylene-pyrone skeleton. Till now, fifty-one kavalactones have been isolated from the genera Piper, Alpinia, Amomum, Polygala, Goniothalamus, and Dumortiera. The bioactivities of six kavalactones, kawain, 7,8-dihydro- kawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyagonin, have been studied extensively. This review aims to give an overview of kavalactones in the plants and their various bioactivities.

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14. Progress in Bioactivities of Phlorotannins from Sargassumi

Jiaoyang Li, Yuxin Wang, Ruihua Guo, Bin Bao, Wenhui Wu

Medicine Research 2018, 2 (1): 180001-5. DOI: 10.21127/yaoyimr20180001

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Bioactive components of marine species have received great attention in recent years, especially phlorotannins isolated from brown algae. This paper summarized progress in the structures and bioactivities of phlorotannins including antibacterial, antioxidant, anticoagulant, anti-diabetic, anti-hypertensive, inhibiting HIV, anti-tumor, anti-allergic, anti-inflammatory, defense activity, and deodorant activities.

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15. Phytochemical Compositions and Bioactivities of Juglans regia Shell and Green Husks

Wenjing Zhou, Zhai Shiyang, Ruihua Guo

Medicine Research 2018, 2 (2): 180007-. DOI: 10.21127/yaoyimr20180007

摘要（362）

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The walnut kernel has appeared on dining tables as a non-staple food and gained much popularity for centuries owing to its flavor as well as the function of food therapy, while the green husk or hard shells enwrapped are always discarded or processed into low value-added products. The waste of walnut green husk and shell can cause environment pollution and the waste of resources. As medicinal food, lots of researches on walnut have been carried out during the past decades, including the walnut kernel, the green husk and the hard shell. The researches on the green husk and hard shell showed the mass of chemical compounds isolated from both green husk and hard shell possesses various bioactivities such as antimicrobial, antioxidant, antitumor, and other effects. In this paper, we summarized phytochemical compositions of green husk and hard shell of walnut (Junglans regia) as well as their bioactivities.

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16. Pathophysiology and Its Clinical Medicine of Acute Myocardial Infarction in ST-Segment Elevation

Ting Wang, Quan Shen, Bin Bao

Medicine Research 2018, 2 (4): 180016-. DOI: 10.21127/yaoyimr20180016

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Acute myocardial infarction (AMI) results from the acute occlusion of a coronary artery, most initiated by the rupture of a thin-cap fibro atheroma with subsequent formation of the occlusive thrombus at the rupture site. Its general symptom is chest pain with a sensation of tightness, pressure, or squeezing. AMI can be divided into NSTEMI and STEMI according to ECG. ST-segment elevation always accompanies with AMI in a severe mortality from 4% to 12%. European Society Of Cardiology (ESC) has recommended that percutaneous transluminal coronary intervention (PCI) is the preferred strategy to realize revascularization for STEMI patients, however, it is often hampered by incomplete microvascular myocardial reperfusion owing to distal embolization of thrombus. Time of door-to-balloon is another key limitation of rapid reperfusion. To address this problem, pharmacologic agents are increasingly used to emergent treat STEMI since their abilities to achieve rapid reperfusion within 12 h of symptom onset. According to the mechanism of thrombogenesis in the coronary artery, antiplatelet drugs and thrombolysis drugs have been widely applied in clinical therapy aiming to impede thrombosis and facilitating fibrinolysis. Antithrombotic drugs including aspirin, clopidogrel, prasugrel and ticagrelor have been successfully applied in clinical practice. Fibrinolytic drugs such as streptokinase (first-generation), tissue plasminogen activator (t-PA) and its recombinant forms (alteplase, reteplase as second-generation, and tenecteplase as third-generation) are also used to treat STEMI. However, side effects such as hematencephalon and non-specificity remains still to be solved. Expanding thrombolytic agents from biological sources for providing safety and efficacy for fibrinolytic drugs is a persistence goal for scientists. Several natural precursors with fibrinolytic function are step into the stage of clinical trials including alfimeprase, desmoteplase, lumbrokinase, etc. For the further study, high-specific thrombolytic agents with a longer plasma half-life to meet clinical needs are expected to be designed by combining the advantages of existing thrombolytic enzyme with molecular biology techniques. Restraining of plasminogen activator inhibitor-1 is another innovative hot-spot for developing fibrinolytic agent.

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17. Progress in Skin Care Efficacy of Lactoferrin

Tong Xie, Wu Qiao, Tinghan Jia, and Ken Kaku

Medicine Research 2022, 6 (1-2): 210015-210015. DOI: 10.21127/yaoyimr20210015

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Lactoferrin is an iron-binding glycoprotein with a variety of biological activities, including anti-inflammatory, antibacterial, antitumor, antiviral, whitening, repairing skin damage caused by inflammation, immune regulation, and osteogenic activity. As a protein with great development potential, lactoferrin is widely used in the fields of food, medicine and cosmetics. The effect of lactoferrin on the skin is particularly prominent, and it has the potential to be used as a new raw material for skin care products. Researchers have reviewed biological activities of lactoferrin and its microbial mechanism of action. Therefore, this article focuses on the skin care efficacy of lactoferrin. This article reviews the latest research results of lactoferrin in skin care efficacy.

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18.

Progress in Chemical Constituents and Bioactivities of Perilla frutescens (L.) Britt

Hui Fang, Shudan Zheng, Jifeng Liu

Medicine Research 2021, 5 (3-4): 210008-210008. DOI: 10.21127/yaoyimr20210008

摘要（344）

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Perilla frutescens (L.) Britt is an annual herb of the genus Perilla in the labiaceae. Its leaves, stalks and fruits can be used as folk medicine. The chemical components in Perilla frutescens (L.) Britt can be divided into volatile oil, terpenoids, triterpenoids, steroids, glycosides, phenylpropanoids and phenolic acids, flavonoids and pigments, which have anti-allergy, antibacterial, hypolipidemia, antioxidation, antitumor, antitussive and antipyretic activities. In this paper, we reviewed research progress of chemical constituents and pharmacological effects of Perilla frutescens to provide new ideas for subsequent development of Perilla frutescens (L.) Britt.

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19. Recent Advances on Small-Molecule Tubulin Inhibitors

Xiu-Li Sun, Yin-Rong Xie, Ning Zhang, Cheng-Ting Zi, Xuan-Jun Wang, and Jun Sheng

Medicine Research 2021, 5 (1): 200024-200024. DOI: 10.21127/yaoyimr20200024

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Microtubules are heterodimers composed of α/β tubulin and make up the cytoskeleton. It plays an important role in maintaining cellular morphology, cell division, signal transduction and other processes. At present, six tubulin inhibitor binding sites have been identified. The inhibitors can be divided into two categories: a type of microtubule polymerization agent includes colchicine site, vinblastine site, maytansine site and prionetin site inhibitors; another category is paclitaxel and laulimalide/peloruside binding site inhibitors are called microtubule depolymerization. Herein, we summarize relevant inhibitors acting on these 6 sites and their research status. With extensive research on tubulin binding sites and inhibitors, anti-tumor tubulin inhibitors will possess very broad clinical prospects.

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20. Progress in Chemical Constituents and Pharmacological Effects of Citrus medica L. var. sarcodactylis Swingle

Shuyu Xu, Yin Qu, Xinyu Liu, Yao Li, Jimin Liu, Hezhong Jiang

Medicine Research 2020, 4 (1-2): 190014-190014. DOI: 10.21127/yaoyimr20190014

摘要（338）

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Citrus medica L. var. sarcodactylis Swingle is known as Foshou fruit that can be used as Chinese medicinal materials and has a health and longevity effect. In recent years, investigations about the chemical compounds of Citrus medica L. var. sarcodactylis Swingle have shown that its main compounds include flavonoids, essential oils, coumarins, and polysaccharides, with anti-inflammatory, antimicrobial, antioxidant activity, effect on the autonomic nervous system, and other pharmacological effects. In this paper, the chemical compositions and pharmacological effects of Citrus medica L. var. sarcodactylis Swingle are summarized.

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21. Recent Advances on Determination Methods of Mycotoxins and Marine Biotoxins

Jiayu Xie, Lingling Wang, Wenhui Wu, Jie Ou

Medicine Research 2018, 2 (3): 180011-. DOI: 10.21127/yaoyimr20180011

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Biotoxins are a group of significant biogenicactive compounds that are usually present in trace amounts in a matrix, and they become the focus of attention in the fields of food safety and medicine research for their toxicities and bioactivities. The biotoxins in food are mainly mycotoxins and marine biotoxins. This review introduced mainly the source, structures and toxicities of aflatoxins (AFs), fumonisins (FBs), trichothecenes (TCTs), zearalenone (ZON), ochratoxin and patulin (PAT) of mycotoxins, which are highly toxic and common in foods. In addition, the classification of marine toxins has also been introduced. Moreover, the detection methods of biotoxins were also introduced including immunological methods, enzyme activity inhibition assay methods, high performance liquid chromatography (HPLC), mass spectrometry (MS), biosensor methods, and aptamer methods, which are intended to provide reference for the study of biotoxins in food. The detection of food biotoxins can prevent food poisoning and control food quality.

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22. Recent Advances on Molecular Modeling Studies of Transient Receptor Potential Ankyrin 1

Carita Sallomy, Maija Lahtela-Kakkonen, and Juri M. Timonen

Medicine Research 2021, 5 (1): 200021-200021. DOI: 10.21127/yaoyigc20200021

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Transient receptor potential ankyrin 1 (TRPA1) is an ion channel involved in nociception. In addition, TRPA1 activation triggers an inflammatory response, which intensifies the sensation of pain. The role of TRPA1 in pain makes it an attractive target for painkiller drug design. The research on TRPA1 antagonists and agonists has increased in recent years with the focus on discovering novel and effective TRPA1 antagonists. This minireview describes some computational drug design methods that have been applied for examining TRPA1 and its ligands. So far, three ligand binding sites have been proposed for TRPA1. The binding of various ligands into TRPA1 has been explored with molecular docking and molecular dynamics. This is the first review that con-centrates on TRPA1 computational studies.

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23. Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview

Yue Zhao, Lijun Wang, Chuanlong Guo, Bo Jiang, Xiangqian Li, Kun Liu, Dayong Shi

Medicine Research 2018, 2 (2): 180009-. DOI: 10.21127/yaoyimr20180009

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As cancer is one of humanity’s biggest killers in the world, scientists have been looking for different drugs as agents to treat cancer. However, current chemotherapeutics is not sufficiently effective. Thiosemicarbazone complexes of transition metals have attracted wide attention due to a great effect of anticancer activity with different mechanisms including ribonucleotide reductase inhibition, metal dependent radical damage, DNA binding, and inhibition of protein synthesis, and so on. In this minireview, we summarize different metal chelators of thiosemicarbazones and their anticancer mechanisms, which are useful for the development of thiosemicarbazone as anticancer drugs.

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24. Natural Products Phenols as Novel Antithrombotic Agents

Wenjing Zhou, Ruihua Guo

Medicine Research 2018, 2 (1): 180002-4. DOI: 10.21127/yaoyimr20180002

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Thrombosis owns the highest incidence, and it is a serious threat to human health. Currently, the clinical antithrombotic drugs suffer from several drawbacks, causing allergic reactions or complications, etc. In recent years, small-molecule compounds isolated from natural products with antithrombotic activities in the field drug research on thrombus disease. In this review, we will focus on representative naturally occurring small molecule phenols with antithrombotic potency and potential for future therapeutic regimens to combat thrombosis disease.

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25. Augmented Reality in Drug Package: a Promising Strategy against Non-adherence in the Treatment of Tuberculosis

Dayse E. de Oliveira, Marcus V. N. de Souza, Wanise B. G. Barroso

Medicine Research 2020, 4 (1-2): 200007-200007. DOI: 10.21127/yaoyimr20200007

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Augmented reality is a technology-based on an interaction between the virtual and real-world, mixing them and expanding their possibilities. This technology is currently used in the most varied areas of human knowledge. The use of augmented reality in drug package has excellent potential in several diseases and could be an indispensable tool, especially in diseases with low medication adherence. In this context, its application in tuberculosis treatment could be of great help, as this treatment presents two major issues: the long-term treatment time (six months) and its severe side effects resulting in its non-adherence to the treatment. In this article, we aim to address the problems related to tuberculosis treatment causing non-adherence by using augmented reality. Using a smartphone in the medicine packaging could gain valuable information making patients be aware of following the treatment until the end.

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26.

Qian Shiyun, Guo Ruihua, Dong Duan, Bao Bin, Wang Shujun, Wu Wenhui

Medicine Research 2017, 1 (1): 20-24. DOI: 10.21127/yaoyimr20170004

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27. Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin

Jun Zhu, Jiejun Cheng, Juan Zhou, Gang Huang, Dannong He

Medicine Research DOI: 10.21127/yaoyimr20190006
预出版日期: 2019-07-18

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28. Bletilla striata Polysaccharides: Structures and Functional Activities

Jinyu Yi, Yingying Huang, and Chaoyan Zhang

Medicine Research 2020, 4 (4): 200009-0. DOI: 10.21127/yaoyimr20200009

摘要（309）

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Bletilla striata (Thunb.) Reichb.f. is a species of genus Bletilla (Family Orchidaceae) and it is a commonly used traditional Chinese medicine. Bletilla striata polysaccharides (BSPs) were extracted from the tuber of Bletilla striata. Herein, we reviewed the extraction and purification methods of BSPs, compared the advantages and disadvantages of different methods comprehensively, and analyzed molecular weights and structural characterization of BSPs systematically. In addition, we analyzed hemostasis, anti-oxidation, anti-aging and other functional activities of BSPs to provide scientific basis for further study of BSPs.

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29. Prodrug Systems (I): Lipid-Based Doxorubicin Prodrugs and Their Nanodelivery Systems

Filipe Olim, Ana Rute Neves, Zhao Wang, Jingjing Sun, Helena Tomás, and Ruilong Sheng

Medicine Research 2020, 4 (1-2): 200013-200013. DOI: 10.21127/yaoyimr20200013

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Using natural lipids to covalently connect with antitumor agents to construct lipid-based molecular prodrugs and their nanosystems is a promising research frontier for sustainable medicinal chemistry, nanobiotechnology and tumor chemotherapy. This paper reviewed recent progress of lipid-based doxorubicin (molecular) prodrugs and their nanodelivery systems, including lipid-doxorubicin prodrugs, stimuli-responsive lipid-doxorubicin prodrugs, and lipid-doxorubicin prodrug-based drug co-delivery nanosystems. Additionally, possible future research outlooks in this field were also discussed.

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30. An Update on Chemical Constituents from Nicotiana tabacum L. and Their Bioactivities from 2017 to 2020

Kuo Xu, Qian Liu, Lin Ni, Yong-Mei Du and Zhong-Feng Zhang

Medicine Research 2020, 4 (4): 200019-200019. DOI: 10.21127/yaoyigc20200019

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^{Nicotiana tabacum} L., well known as tobacco, could be not only used for raw materials of producing cigarettes, but also as a folk Chinese herbal medicine. This paper offers a systematic review of newly reported compounds from N. tabacum over the past four years covering the literatures from the beginning of 2017 through the end of 2020 and describes their structural diversities and bioactivities. A total of 46 natural compounds and 42 references were updated and compiles in this review, which may be of interest to pharmacognosists and natural products chemists.

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31. Progress in Polyketides Isolated from Marine Sponge-Associated Fungi

Mingxiang Liu, Bin Bao, Ming Ma, Wenhui Wu

Medicine Research 2018, 2 (2): 180006-. DOI: 10.21127/yaoyimr20180006

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In recent years, marine natural products isolated from associated microorganisms have become a hot topic in medicine. It has been reported that secondary metabolites produced by sponge-associated fungi are of great importance for the discovery of active substances with novel structures and they own broad prospects for clinical medicine and the development of drugs. Herein, we summarize the structures of marine sponge-associated fungi including lactones, anthraquinones, pyrenes, chromones and others, as well as the bioactivities of polyketides from marine sponge-associated fungi.

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32.

Yang Jing, Wang Shujun, Yang Weijie, Yu Xiaowei, Bao Bin

Medicine Research 2017, 1 (1): 16-19. DOI: 10.21127/yaoyimr20170005

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33. Adverse Reactions and Resistance of Anticancer Drug Cisplatin

Zhonglie Yang, Li Lin, Xiaoyan Peng, Xinyi Yu, Xiaobin Zhang, Hezhong Jiang, and Jiahong Li

Medicine Research 2021, 5 (1): 200022-200022. DOI: 10.21127/yaoyimr20200022

摘要（296）

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Since 1978, cisplatin has become a leading anticancer drug for its high efficacy and unique mechanism of action. As a representative of platinum anticancer drugs, cisplatin has an excellent curative effect and broad application range of cancer. However, its application is limited by high toxicity and drug resistance. This review mainly focuses on adverse reactions and drug resistance of cisplatin.

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34. Progress in Chemical Constituents and Bioactivities of Broussonetia pa-pyrifera (L.) Vent

Fang Li, Tingyu Wen, Jifeng Liu

Medicine Research DOI: 10.21127/yaoyimr20190005
预出版日期: 2019-06-18

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35. Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways

Mengcheng Li, Yongpeng Wang, Lei Tian, Afsar Khan, Yudan Wang, Yaping Liu, Meilian Yang, Jianxin Cao, Guiguang Cheng, and Tianrui Zhao

Medicine Research 2021, 5 (2): 210003-210003. DOI: 10.21127/yaoyimr20210003

摘要（285）

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Oxaliplatin (L-OHP) is a new platinum anticancer drug, which is used for the treatment of metastatic colorectal cancer or the adjuvant treatment of stage III colon cancer. T-cell acute lymphoblastic leukemias (T-ALLs) are invasive thymocytic malignant tumors with poor prognosis. The purpose of this study was to evaluate the cytotoxic effect of L-OHP on human T-ALL cell lines MOLT-4, Jurkat, CCRF-CEM, and CEM/C1 cells. The CCK-8 method results showed that L-OHP significantly inhibited T-ALL cells proliferation. The inhibition of these T-ALL cells prolife by L-OHP seems to be related to the induction of cell cycle arrest. The effect of L-OHP on the cell cycle distribution of T-ALL cells varies with cell types. As to cells apoptosis, Annexin V/Propidium iodide assay disclosed that L-OHP prominently induced T-ALL cells apoptosis by activating the pathways of mitochondrial biogenesis and is more sensitive to MOLT-4 cells. Western blot analysis showed that L-OHP treatment could promote apoptosis through down-regulated Bcl-2 protein level, up-regulated Bax and caspase-9 proteins levels and cell cycle arrest by inhibiting the PI3K/Akt signaling pathway in MOLT-4 cells. Our results indicate that L-OHP, as a new type of platinum anticancer drug, may attract more attention in the future treatment of T-ALL.

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36.

Liu Wei, Yu Xiaowei

Medicine Research 2017, 1 (1): 3-5. DOI: 10.21127/yaoyimr20170001

摘要（282）

HTML （54）

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37. Subcellular Distribution of DNA Origami Nanostructures

Yuanjie Zhu, Ping Wang, Ting Liu, Yi Chen, Ruxin Zhou, Xiaodi Li, Yan Xu, Yinan Yan, Jun Zhu, Gang Huang, Dannong He

Medicine Research 2018, 2 (4): 190100-. DOI: 10.21127/yaoyimr20190100

摘要（281）

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As a new type of material with application prospect in drug delivery system, DNA origami nanostructures (DONs) have showed unparalleled abilities on nanoparticle drug delivery. However, the subcellular distribution of DONs after entering cells remained unclarified. Herein, we studied the phagocytic rate of U87 cells on fluorescent triangular DNA origami and Cy5 labelled Gold nanoparticles (Cy5-AuNPs) after 24 h. Atomic force microscope, confocal microscopy and immunofluorescence analysis (four organelles) were used to characterize their morphology. We found that DONs distributed in late endosome and lysosome. Meanwhile, gold nanoparticles enter the cells from early endosome to late endosome, and then exit the cells through exocytosis. The results provide us the novel insight for the design and optimization of DNA triangular origami nanostructures vehicles for drug delivery.

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38.

Natural Products from the genus Daldinia and Their Bioactivities

Jing Li, Luohao Li, Runqing Zhu, Vuanghao Lim, Qianqian Sun, and Lizhen Fang

Medicine Research 2021, 5 (3-4): 210005-210005. DOI: 10.21127/yaoyimr20210005

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Genus Daldinia is a unique source of natural products, which possess many pharmacological effects such as antibacterial activity, cytotoxicity, antioxidant activity, α-glucosidase inhibitory activity, and so on. Recently, most studies of genus Daldinia were focused on D.eschscholzii, D.concentrica and D.sp. This paper covers nearly a decade of research on Daldinia, focusing on the chemical structures and related biological activities of the secondary metabolites produced.

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39. Stilbenoids from Leguminosae and their Bioactivities

Xinyu Lei, Qinru Zhou, Wenju Li, Guifang Qin, Xiangchun Shen, Nenling Zhang

Medicine Research 2019, 3 (4): 200004-. DOI: 10.21127/yaoyimr20200004

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Stilbenoids, usually found in Leguminosae, are a class of compounds with the skeleton of stilbene or their polymers, existing mostly in the xylem of plants. Till now, one hundred and seventy-six stilbenoids have been isolated from plants of Leguminosae. Herein, stilbene compounds and their derivatives in Leguminosae and their biological activities including anti-neoplastic, anti-bacterial, anti-inflammation are reviewed.

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40. Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms

Chunxia Gan, Chengting Zi, Jun Sheng, Xuanjun Wang, and Huanhuan Xu

Medicine Research 2021, 5 (2): 210006-210006.

摘要（278）

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Skin is the largest human organ, which always suffered from environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin can take different protective mechanisms to maintain balance, excessive stresses can disrupt these systems, resulting in the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Phytochemicals are biologically active compounds derived from plants and herbal products, which appear to be beneficial in the battle against cancer as they exhibit anti-cancer effects and are inexpensive, widely available, and well tolerated. Studies have demonstrated that phytochemicals can act on various cellular processes including cell cycle, apoptosis and redox metastasis to inhibit the development and progression of skin cancer. This article mainly focuses on the progress in anti-skin cancer activity of phytochemicals and underlying molecular mechanisms, which will hopefully provide valuable insights into clinical applications of phytochemicals for treatment of skin cancers.

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