Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis

doi:10.21127/yaoyimr20220001

Medicine Research ›› 2022, Vol. 6 ›› Issue (1-2): 220001-220001.DOI: 10.21127/yaoyimr20220001

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Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis

Xuewei Wang,^a, Yanqing Yang,^a, Yan Li,^*,a, Chaofei Ba^*,b

^aThe First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China;
^bThe Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, China

Received:2022-02-17 Accepted:2022-03-13 Online:2022-06-20 Published:2022-06-17
Contact: * E-mail: liyanr@hotmail.com (Y. L.); 936177139@qq.com (C. B.)

Abstract

Abstract: Loss of retinal ganglion cells (RGCs) is the main cause of glaucoma and traumatic optic neuropathy, which can eventually lead to optic nerve atrophy and vision loss. Acteoside is a natural phenylpropanoid glycoside compound with many pharmacological activities, including neuroprotective effects. Studies have shown that acteoside can protect RGCs from damage; however, the underlying mechanism remains unclear. In this paper, we investigated whether acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis. H & E staining showed that acteoside treatment significantly attenuated RGC damage in acute high intraocular pressure-induced rats. Additionally, immunohistochemical staining and immunoblotting analysis demonstrated that acteoside treatment significantly inhibited the expression of Bax and increased the expression of Bcl-xL in retina tissues. Collectively, these findings demonstrate that acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis, suggesting that acteoside has a promising potential in glaucoma treatment.

Key words: retinal ganglion cells, damage, acteoside, Bax, Bcl-xL

Xuewei Wang, Yanqing Yang, Yan Li, Chaofei Ba. Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis[J]. Medicine Research, 2022, 6(1-2): 220001-220001.

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Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis

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