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Recent Advances on Anticancer Effects and Molecular Mechanisms of Maslinic Acid
Jin Li, Xiaomei Yang, Wei Jiang, Qianqian Hu, Xuanjun Wang, Huanhuan Xu
Medicine Research    2022, 6 (3-4): 220002-220002.   DOI: 10.21127/yaoyimr20220002
Abstract149)      PDF (482KB)(139)       Save
Cancer has become a serious public health concern that affects millions of individuals annually in the world. Surgical resection, chemotherapy and radiotherapy have been considered as the standard treatment strategies for different kinds of cancers. Among them, chemotherapeutic agents are usually used for the treatment of malignancies but toxic side effects and drug resistance limit their clinical efficacy. Natural compounds isolated from medicinal plants are excellent and reliable sources of new anticancer drugs. Maslinic acid is a naturally occurred pentacyclic triterpenoid with anticancer activities. This review mainly focuses on recent advances on anticancer effects and molecular mechanisms of maslinic acid and will hopefully provide valuable insights into clinical application of maslinic acid to the treatment of cancers.
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Progress in Phytochemical and Bioactivities of Areca catechu L
Zhenshuai Tang, Jifeng Liu
Medicine Research    2022, 6 (3-4): 220004-220004.   DOI: 10.21127/yaoyimr20220004
Abstract138)      PDF (576KB)(114)       Save
Areca catechu L is a genus of plants whose leaves and fruits can be used as folk medicine. The chemical composition of A. catechu can be divided into alkaloids, flavonoids, tannins, terpenoids, sterols, fatty acids, etc. It has pharmacological effects such as anti-inflammatory, antioxidant, antibacterial, antidepressant, hypotensive, etc., while having toxic side effects such as oral toxicity, hepatotoxicity and addiction. This paper reviews the progress of research on chemical composition and pharmacological effects and toxic side effects of A. catechu, and provides new ideas for subsequent development of A. catechu.
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Preparation of Ti Doped Nano-ZnO Dispersion and Their Application in Deodorization and Antibiosis
Lin Lin, Shuhong Wu, Xiaoyan Wu, Zheng Zhu, Yongxin Wu, Jun Zhu
Medicine Research    2022, 6 (3-4): 220003-220003.   DOI: 10.21127/yaoyimr20220003
Abstract100)      PDF (873KB)(71)       Save
To develop an effective deodorant and antibacterial agent, we prepare a Ti doped nano-ZnO through a low temperature hydrothermal route. The shape and size of these as-prepared samples can be tuned effectively by controlling the reaction conditions, such as the molar ratio of Ti/Zn. Furthermore, the sample with an appropriate portion of Ti and Zn is selected to obtain dispersion for improving sample activity and avoiding sample agglomeration. XRD, SEM, EDX and DLS are performed to characterize the structure and morphology of samples. Furthermore, the typical dispersion is used to remove odorous molecules and kill bacteria. The results show that polycarboxylic acid can be used to improve the dispersibility and stability of nanoparticles, and the well-dispersed dispersion is high effective for deodorization and antibiosis. Moreover, CCK-8 assays are performed to evaluate the cytotoxicity of dispersions with different size. The result reveals that dispersion with a smaller particle size displayed more serious toxicity. Thus, we suggest that the obtained dispersion can be used as a deodorant and antibacterial agent, but it is necessary to take precautions when handling the dispersion because the nanoparticles, special smaller nanoparticles is more likely to cause serious cytotoxicity.
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Progress in Synthetic Methodology of Coumarins
Sijin Hang, Yinan Wang, Ruilong Sheng, Ruihua Guo
Medicine Research    2022, 6 (3-4): 220005-220005.   DOI: 10.21127/yaoyimr20220005
Abstract72)      PDF (1018KB)(85)       Save
The basic structure of coumarins contain a benzene ring and a pyrone ring, which drive their values on biological research and potential therapeutic properties. In recent years, the synthesis of coumarins and their derivatives have drawn much attention from organic chemists and medicinal chemists. Herein, we summarized recent advances on synthetic methodologies of coumarins from 2011 to 2021.
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Antibacterial Activity of Extracellular Vesicles from Symbiotic Vaginal Lactobacilli
Lanxi Zheng, Kehai Liu*
Medicine Research    2023, 7 (1-2): 230003-230003.   DOI: 10.21127/yaoyimr20230003
Abstract31)      PDF (1093KB)(13)       Save
Vaginal microorganisms, dominated by Lactobacillus spp., are an important defense against infections including pathogenic sexually transmitted infections. Extracellular vesicles (EVs) are recognized and endocytosed by tissue cells through specific interactions between membrane surface proteins, and thereafter deliver their molecular cargo. Bacteria can use their EVs to interact with neighboring bacteria and play an important role in the physiology and pathogenesis of cells. Herein, we investigated whether the bacteriostatic effect of Lactobacillus was mediated by extracellular vesicles released by these bacteria. L. gasseri-derived EVs were isolated by ultracentrifugation and loaded with metronidazole to observe their antibacterial activity. Our results showed that L. gasseri-derived EVs could effectively encapsulate drug, enhanced drug retardation, and had good biosafety. EVs and EVs-metronidazole have inhibitory effects on E. coli, S. aureus, and L. monocytogenes, with the best inhibitory effect on L. monocytogenes. Together, our work provides a new potential strategy for vaginitis treatment.
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Physicochemical Properties and in vitro Digestion Characteristics of Polysaccharide from Auricularia auricula
Min Lei, Yuting Liu, Yunbo Ge, Chaoyan Zhang
Medicine Research    2023, 7 (1-2): 230004-230004.   DOI: 10.21127/yaoyimr20230004
Abstract29)      PDF (640KB)(10)       Save
Auricularia auricula polysaccharide (AAP) was extracted with ethanol of different concentrations (50%, 60%, 70%, 80%, 90%). Taking the yield, total sugar content, and uronic acid content as the indexes, the optimal alcohol precipitation concentration of AAP was 50%, and the polysaccharide content was 58.89%. In vitro digestion experiment showed that the content of reducing sugar in AAP was almost unchanged in the saliva and gastric juice digestion phase. However, the reducing sugar content of AAP increased from 0.062 mg/mL at 0.5 h to 1.162 mg/mL at 3 h during the intestinal juice digestion phase. In addition, in vitro antioxidant results showed that AAP still maintained high 2,2’-azido bis (3-ethyl benzothiazole line-6-sulfonic acid) (ABTS) free radical scavenging activity after digestion.
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Contents: Med. Res. 3-4/2022
Medicine Research    2022, 6 (3-4): 0-.  
Abstract27)      PDF (288KB)(17)       Save
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Research Advances and Applications of Polysaccharide-Based Complex Hydrogels
Yuting Liu, Yunbo Ge, Chaoyan Zhang
Medicine Research    2023, 7 (1-2): 230005-230005.   DOI: 10.21127/yaoyimr20230005
Abstract26)      PDF (689KB)(8)       Save
This paper introduces research background of polysaccharide-based composite hydrogel materials, discusses definition, classification and preparation of hydrogels, and summarizes research progress of chitosan-based hydrogels, hyaluronic acid-based hydrogels, alginate-based hydrogels, starch-based hydrogels and cellulose-based hydrogels according to different types of polysaccharides. In addition, we summarize the applications of polysaccharide-based complex hydrogels in wound healing, tissue engineering, and drug delivery. Finally, the development opportunities and challenges faced by polysaccharide-based complex hydrogels are summarized, and the future research directions are prospected, hoping to broaden their potential application fields.
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Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease
Leandro Louback da Silva, Beatriz de Frias Leite, Emerson Teixeira da Silva, Marcus Vinícius Nora de Souza
Medicine Research    2023, 7 (1-2): 230002-230002.   DOI: 10.21127/yaoyimr20230002
Abstract21)      PDF (418KB)(8)       Save
Alzheimer's disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age of 85. It is responsible for incapacitation of the individual by degrading cognitive functions, and its evolution leads the individual to death after a few years. It is characterized by brain degeneration triggered by several factors. One of the triggering factors is in the acetylcholine system. There is a decrease in the count of this neurotransmitter in individuals with this disease. The involvement of endogenous metal ions such as iron, copper, and zinc has also been involved in neurodegeneration mechanisms, in which there is the formation of radical species that cause oxidative stress, with important contribution of the neutrophil-derived enzyme myeloperoxidase, forming lesions in the neuronal cytoplasm and functional deficiency of neurons. In the present work, we report the evaluation of seventeen Camphor hydrazone derivatives 3a—3q, prepared in accordance with our previous work, as probable inhibitors of myeloperoxidase (MPO), acetylcholinesterase (AChE), and free radical-scavenging, to be used as potential agents against AD. Nine compounds showed significant activity against MPO. Among them, 3j and 3k had 78.4 and 53.9 μM (IC 50), respectively. Three compounds showed stronger activity, 3d, 3k, and 3l with EC 50 of 15.2, 21.3, and 14.4 µM, respectively, for free radical-scavenging activity, being similar to the standard quercetin (12.8 µM). All the final compounds were analyzed for drug-likeness. With exception for 3e and 3p, all were suitable on all filters evaluated. These results show that the compounds of hydrazone class are promising in the search for potential candidates for new agents against AD.
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Contents: Med. Res. 1-2/2023
Medicine Research    2023, 7 (1-2): 0-0.  
Abstract16)      PDF (297KB)(5)       Save
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