Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems

doi:10.21127/yaoyimr20230008

Abstract

Abstract: In the past decades, many polyethylene glycol (PEG)-containing polymers were developed and widely utilized to prepare functionalized nano delivery systems with hydrophilic shielding feature and high body fluid/environmental stability. Notably, some surface physicochemical properties of the PEG-containing polymers largely determined their solution properties and interactions with other biomolecules, which thus subsequently influenced their biological behaviors. In this paper, we summarized recent advances on the surface physicochemical properties of PEG-containing polymer nano systems and their impacts on self-assembly, solution stability, biomolecular interactions, as well as drug delivery. Future research outlooks in this area were also stated and discussed.

Key words: polyethylene glycol-containing, molecular packaging parameter, surface density, diffusion, nano delivery systems

Zhao Wang, Jingjing Sun, Ruilong Sheng. Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems[J]. Medicine Research, 2023, 7(3-4): 230008-230008.

References

[1] Ibrahim M.; Ramadan E.; Elsadek N. E.; Emam S. E.; Shimizu T.; Ando H.; Ishima Y.; Elgarhy O. H.; Sarhan H. A.; Hussein A. K.; Ishida T.Polyethylene glycol (PEG): The Nature, Immunogenicity, and Role in the Hypersensitivity of PEGylated Products. J. Control. Release 2022, 351, 215-230.
[2] Wang Z.; Guo X.; Hao L.; Zhang X.; Lin Q.; Sheng R.Charge-Convertible and Reduction-Sensitive Cholesterol- Containing Amphiphilic Copolymers for Improved Doxorubicin Delivery. Materials 2022, 15, 6476.
[3] Thi Nguyen, N. T.; Yun, S.; Lim, D. W.; Lee, E. K. Shielding Effect of a PEG Molecule of a Mono-PEGylated Peptide Varies with PEG Chain Length. Prep. Biochem. Biotechnol. 2018, 48, 522-527.
[4] Olim F.; Neves A. R.; Vieira M.; Tomás H.; Sheng R.Self-Assembly of Cholesterol-Doxorubicin and TPGS into Prodrug-Based Nanoparticles with Enhanced Cellular Uptake and Lysosome-Dependent Pathway in Breast Cancer Cells. Eur. [J]. Lipid Sci. Technol. 2021, 123, 2000337.
[5] Martínez-Negro, M.; Russo, D.; Prévost, S.; Teixeira, J.; Morsbach, S.; Landfester, K. Poly(ethylene glycol)-Based Surfactant Reduces the Conformational Change of Adsorbed Proteins on Nanoparticles. Biomacromolecules 2022, 23, 4282-4288.
[6] Yin L.; Pang Y.; Shan L.; Gu J.The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems. Drug Metab. Dispos. 2022, 50, 827-836.
[7] Iakimov N. P.; Zotkin M. A.; Dets E. A.; Abramchuk S. S.; Arutyunian A. M.; Grozdova I. D.; Melik-Nubarov, N. S., Evaluation of Critical Packing Parameter in the Series of Polytyrosine-PEG Amphiphilic Copolymers. Colloid Polym. Sci. 2021, 299, 1543-1555.
[8] Nagarajan R.Molecular Packing Parameter and Surfactant Self-Assembly: The Neglected Role of the Surfactant Tail. Langmuir 2002, 18, 31-38.
[9] Shi L.; Zhang J.; Zhao M.; Tang S.; Cheng X.; Zhang W.; Li W.; Liu X.; Peng H.; Wang Q.Effects of Polyethylene Glycol on the Surface of Nanoparticles for Targeted Drug Delivery. Nanoscale 2021, 13, 10748-10764.
[10] Poornima K.; Anu P.; Anju G.,Understanding the Stealth Properties of PEGylated Lipids: A Mini-Review. Int. [J]. Lipids 2020, 1, 1-20.
[11] Wang Z.; Ye Q.; Yu S.; Akhavan B.Poly Ethylene Glycol (PEG)-Based Hydrogels for Drug Delivery in Cancer Therapy: A Comprehensive Review. Adv. Healthc. Mater. 2023, 12, 2300105.
[12] Suk J. S.; Xu Q.; Kim N.; Hanes J.; Ensign L. M.PEGylation as a Strategy for Improving Nanoparticle-based Drug and Gene Delivery. Adv. Drug Deliv. Rev. 2016, 99, 28-51.
[13] Mohapatra A.; Uthaman S.; Park I. K.Chapter 10 - Polyethylene Glycol Nanoparticles as Promising Tools for Anticancer Therapeutics. In Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics, Kesharwani, P.; Eds.: Paknikar, K. M.; Gajbhiye, V. Academic Press, 2019, pp. 205-231.
[14] Zhang K.; Tang X.; Zhang J.; Lu W.; Lin X.; Zhang Y.; Tian B.; Yang H.; He H.PEG-PLGA Copolymers: Their Structure and Structure-influenced Drug Delivery Applications. J. Control. Release 2014, 183, 77-86.
[15] Dutt S.; Siril P. F.; Remita S.Swollen Liquid Crystals (SLCs): a Versatile Template for the Synthesis of Nano Structured Materials. RSC Adv. 2017, 7, 5733-5750.
[16] Piñol R.; Jia L.; Gubellini F.; Lévy D.; Albouy P. A.; Keller P.; Cao A.; Li M. H.Self-Assembly of PEG-b-Liquid Crystal Polymer: The Role of Smectic Order in the Formation of Nanofibers. Macromolecules 2007, 40, 5625-5627.
[17] Li M.; Jiang S.; Simon J.; Paßlick D.; Frey M. L.; Wagner M.; Mailänder V.; Crespy D.; Landfester K.Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime. Nano Lett. 2021, 21, 1591-1598.
[18] Cruje C.; Chithrani D. B.Polyethylene Glycol Density and Length Affects Nanoparticle Uptake by Cancer Cells. [J]. Nanomed. Res. 2014, 1.
[19] Labouta H. I.;Gomez-Garcia, M. J.; Sarsons, C. D.; Nguyen, T.; Kennard, J.; Ngo, W.; Terefe, K.; Iragorri, N.; Lai, P.; Rinker, K. D.; Cramb, D. T. Surface-grafted Polyethylene Glycol Conformation Impacts the Transport of PEG-Functionalized Liposomes through a Tumour Extracellular Matrix Model. RSC Adv. 2018, 8, 7697-7708.
[20] Chen J.; Wang H.; Zhang L.; Yan W.; Sheng R.Facile preparation of PEGylated Polyethylenimine Polymers as Vaccine Carriers with Reduced Cytotoxicity and Enhanced Interleukin-2 (IL-2) Production. Colloid Surf. B-Biointerfaces 2023, 230, 113520.
[21] Huckaby J. T.; Lai S. K.PEGylation for Enhancing Nanoparticle Diffusion in Mucus. Adv. Drug Deliv. Rev. 2018, 124, 125-139.
[22] Pozzi D.; Colapicchioni V.; Caracciolo G.; Piovesana S.; Capriotti A. L.; Palchetti S.; De Grossi, S.; Riccioli, A.; Amenitsch, H.; Laganà, A. Effect of Polyethyleneglycol (PEG) Chain Length on the Bio-nano-interactions between PEGylated Lipid Nanoparticles and Biological Fluids: From Nanostructure to Uptake in Cancer Cells. Nanoscale 2014, 6, 2782-2792.
[23] Li M.; Jiang S.; Simon J.; Paßlick D.; Frey M.-L.; Wagner M.; Mailänder V.; Crespy D.; Landfester K.Brush Conformation of Polyethylene Glycol Determines the Stealth Effect of Nanocarriers in the Low Protein Adsorption Regime. Nano Lett. 2021, 21, 1591-1598.
[24] Perry J. L.; Reuter K. G.; Kai M. P.; Herlihy K. P.; Jones S. W.; Luft J. C.; Napier M.; Bear J. E.; DeSimone, J. M. PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics. Nano Lett. 2012, 12, 5304-5310.
[25] van den Berg, L.; Toja Ortega, S.; van Loosdrecht, M. C. M.; de Kreuk, M. K. Diffusion of Soluble Organic Substrates in Aerobic Granular Sludge: Effect of Molecular Weight. Water Research X 2022, 16, 100148.
[26] Rasmussen M. K.; Pedersen J. N.; Marie R.Size and Surface Charge Characterization of Nanoparticles with a Salt Gradient. Nat. Commun. 2020, 11, 2337.
[27] Smith M. C.; Crist R. M.; Clogston J. D.; McNeil, S. E. Zeta Potential: A Case Study of Cationic, Anionic, and Neutral Liposomes. Anal. Bioanal. Chem. 2017, 409, 5779-5787.
[28] Conte C.;Dal Poggetto, G.; J. Swartzwelter, B.; Esposito, D.; Ungaro, F.; Laurienzo, P.; Boraschi, D.; Quaglia, F., Surface Exposure of PEG and Amines on Biodegradable Nanoparticles as a Strategy to Tune Their Interaction with Protein-Rich Biological Media. Nanomaterials 2019, 9, 1354.
[29] Sun J.; Wang Z.; Cao A.; Sheng R.,Synthesis of Crosslinkable Diblock Terpolymers PDPA-b-P(NMS-co-OEG) and Preparation of Shell-crosslinked pH/redox-dual Responsive Micelles as Smart Nanomaterials. RSC Adv. 2019, 9, 34535-34546.
[30] Neves A. R.; Sheng R.; Mendes F.; Olim F.; Tomás H.; Sun J.; Wang Z.Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy. Med. Res. 2021, 5, 200023.
[31] Neves A. R.; Sheng R.; Olim F.; Tomás H.; Sun J.; Wang Z.,Prodrug Systems (I): Lipid-Based Doxorubicin Prodrugs and Their Nanodelivery Systems. Med. Res. 2020, 4, 200013.
[32] Liu G.; Li Y.; Yang L.; Wei Y.; Wang X.; Wang Z.; Tao L.,Cytotoxicity Study of Polyethylene Glycol Derivatives. RSC Adv. 2017, 7, 18252-18259.
[33] Lee S.; Tong X.; Yang F.,Effects of the poly(ethylene glycol) hydrogel Crosslinking Mechanism on Protein Release. Biomater. Sci. 2016, 4, 405-411.