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Medicine Research ›› 2023, Vol. 7 ›› Issue (3-4): 230008-230008.DOI: 10.21127/yaoyimr20230008

• Perspectives • Previous Articles     Next Articles

Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems

Zhao Wanga, Jingjing Sunb, Ruilong Shengc,*   

  1. aSchool of Material Engineering, Jinling Institute of Technology, Nanjing, Jiangsu 211169, China;
    bCenter for Pharmacogenetics, School of Pharmacy, University of Pittsburgh, Pittsburgh,PA 15261, United States;
    cCQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada,9000-390 Funchal, Portugal
  • Received:2023-10-06 Accepted:2023-10-22 Online:2023-12-20 Published:2024-02-22
  • Contact: * Email: ruilong.sheng@staff.uma.pt (R. S.)

Abstract: In the past decades, many polyethylene glycol (PEG)-containing polymers were developed and widely utilized to prepare functionalized nano delivery systems with hydrophilic shielding feature and high body fluid/environmental stability. Notably, some surface physicochemical properties of the PEG-containing polymers largely determined their solution properties and interactions with other biomolecules, which thus subsequently influenced their biological behaviors. In this paper, we summarized recent advances on the surface physicochemical properties of PEG-containing polymer nano systems and their impacts on self-assembly, solution stability, biomolecular interactions, as well as drug delivery. Future research outlooks in this area were also stated and discussed.

Key words: polyethylene glycol-containing, molecular packaging parameter, surface density, diffusion, nano delivery systems

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