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Cover Illustration
2022, Vol.6  No.1-2
The cover picture shows a persulfate-enhanced silver ion against SARS-CoV-2 with 99.54% of antiviral activity, evidencing its potential as an efficient and rapid alternative for controlling viral spread. More details are discussed in the article by Zhu et al. on page 210013.

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  • Table of Content
      20 June 2022, Volume 6 Issue 1-2 Previous Issue   
    For Selected: View Abstracts Toggle Thumbnails
    Contents
    Contents: Med. Res. 1-2/2022
    Medicine Research. 2022, 6 (1-2): 0.  
    Abstract   PDF (464KB) ( )
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    Minireviews
    Recent Advances on Drug Treatments of Rheumatoid Arthritis
    Chunxia Gan, Mingzhen Yu, Ergu Chen, Xuanjun Wang, Huanhuan Xu
    Medicine Research. 2022, 6 (1-2): 210012.   DOI: 10.21127/yaoyimr20210012
    Abstract   PDF (565KB) ( )
    Rheumatoid arthritis is a chronic autoimmune disorder caused by persistent activation of immune system. Rheumatoid arthritis is the most prevalent form of inflammatory arthritis and always has critical consequences to the joints. Reducing pain, decreasing inflammation and blocking immune response are the main ideas for the treatment of rheumatoid arthritis. There are several therapeutic drugs are available for rheumatoid arthritis: nonsteroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biologic anti-rheumatic drugs. All these drugs are used alone or in combination with methotrexate, which have produced a remarkable impact on the occurrence and development of rheumatoid arthritis. Herein, we summarized the treatment options and some new drugs.
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    Chemical Research on Limonoids Isolated from the Fruits of Melia toosendan
    Hao Wang, Hao-Yan Dong, Yan-Fang Liu, Yu-Xiang Ma, Wei Wang, Zhi-Mou Guo and Chao-Ran Wang
    Medicine Research. 2022, 6 (1-2): 210014.   DOI: 10.21127/yaoyimr20210014
    Abstract   PDF (1100KB) ( )
    As the characteristic components from the fruits of Melia toosendan, limonoids attract continuous research interest for their chemistry and biodiversity, and their analogues are continuously obtained from this plant. Thus, limonoids isolated from the fruits of M. toosendan were investigated, classified and the biogenic metabolic pathway were supposed to provide more information for further research on the title plant.
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    Progress in Skin Care Efficacy of Lactoferrin
    Tong Xie, Wu Qiao, Tinghan Jia, and Ken Kaku
    Medicine Research. 2022, 6 (1-2): 210015.   DOI: 10.21127/yaoyimr20210015
    Abstract   PDF (724KB) ( )
    Lactoferrin is an iron-binding glycoprotein with a variety of biological activities, including anti-inflammatory, antibacterial, antitumor, antiviral, whitening, repairing skin damage caused by inflammation, immune regulation, and osteogenic activity. As a protein with great development potential, lactoferrin is widely used in the fields of food, medicine and cosmetics. The effect of lactoferrin on the skin is particularly prominent, and it has the potential to be used as a new raw material for skin care products. Researchers have reviewed biological activities of lactoferrin and its microbial mechanism of action. Therefore, this article focuses on the skin care efficacy of lactoferrin. This article reviews the latest research results of lactoferrin in skin care efficacy.
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    Reports
    SARS-CoV-2 Inactivation by Persulfate-Enhanced Silver Ions
    Jingyao Zhu, Shuhong Wu, Yanwen Fang, Lin Lin, Jun Zhu
    Medicine Research. 2022, 6 (1-2): 210013.   DOI: 10.21127/yaoyimr20210013
    Abstract   PDF (428KB) ( )
    The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health concern with over 100 million confirmed cases. Considering the pandemic emergency, new safety strategies must be found against SARS-CoV-2 virus. In present study, a persulfate-enhanced silver ion is obtained against SARS-CoV-2, evidencing its potential as an efficient and rapid alternative for controlling viral spread. The synergistic interacting between Ag+ and K2S2O8 is proposed, which means that K2S2O8 can oxidize +1 of silver ions to a higher valance state and can produce highly oxidative sulfate radical anions (SO4-) for a kind of compound disinfectant with silver ions. The persulfate-enhanced silver ion has 99.54% of Anti-SARS- CoV-2 viral activity at a low concentration of 100 ppm and 99.999%, 99.999% and 99.99% of the killing effect on Escherichia coli, Staphylococcus aureus and Candida albicans at a lower concentration of 30 ppm and a short time of 0.5 min. Thus, the obtained materials may be made available for hand hygiene and for disinfection of surfaces, washing equipment of individual protection in hospitals and laboratories, as well as for household use.
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    Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis
    Xuewei Wang, Yanqing Yang, Yan Li, Chaofei Ba
    Medicine Research. 2022, 6 (1-2): 220001.   DOI: 10.21127/yaoyimr20220001
    Abstract   PDF (606KB) ( )
    Loss of retinal ganglion cells (RGCs) is the main cause of glaucoma and traumatic optic neuropathy, which can eventually lead to optic nerve atrophy and vision loss. Acteoside is a natural phenylpropanoid glycoside compound with many pharmacological activities, including neuroprotective effects. Studies have shown that acteoside can protect RGCs from damage; however, the underlying mechanism remains unclear. In this paper, we investigated whether acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis. H & E staining showed that acteoside treatment significantly attenuated RGC damage in acute high intraocular pressure-induced rats. Additionally, immunohistochemical staining and immunoblotting analysis demonstrated that acteoside treatment significantly inhibited the expression of Bax and increased the expression of Bcl-xL in retina tissues. Collectively, these findings demonstrate that acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis, suggesting that acteoside has a promising potential in glaucoma treatment.
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