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Medicine Research ›› 2024, Vol. 8 ›› Issue (1): 240001-240001.DOI: 10.21127/yaoyimr20240001

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2,4-Dinitrophenylhydrazine Pre-column Derivatization: High Performance Liquid Chromatography Determination of Residual Formaldehyde in Pharmaceutical Industry and Key Parameters Analysis

Guoyin Yina,*, Ruilong Shengb,*   

  1. a10132 Baylee Ln, San Diego, CA92127, United States;
    bCQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
  • Received:2024-01-06 Accepted:2024-02-28 Online:2024-03-20 Published:2024-04-25
  • Contact: Email: nancy.guoyin.yin@gmail.com (G. Y.), ruilong.sheng@staff.uma.pt (R. S.)

Abstract: Formaldehyde is a colorless gas with a pungent odor, and it is commonly used in many industries to produce resins, plastics, textiles, household products, as well as pharmaceutics. Accurate formaldehyde analysis is significant for environmental and industrial control. In this paper, formaldehyde is analyzed as its 2,4-dinitrophenylhydrazine derivative through a high performance liquid chromatography method. The method has been validated for specificity, limit of detection, limit of quantification, linearity and range, precision, accuracy, and solution stability, which showed simplicity, speed, and accuracy, making it well-suited for the determination of traceable levels of formaldehyde in the pharmaceutical industry.

Key words: formaldehyde, derivatization, 2, 4-dinitrophenylhydrazine, high performance liquid chromatography, parameters

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