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Medicine Research ›› 2020, Vol. 4 ›› Issue (4): 200016-200016.DOI: 10.21127/yaoyimr20200016

Special Issue: Anticancer Agents

• Report • Previous Articles     Next Articles

Synthesis and Cytotoxic Activity of Arenecarbaldehyde 2-Pyridinylhydrazone Derivatives

Alessandra Campbell Pinheiro,a Sarah Sant’Anna Maranhão,b Guilherme Graziany Camelo Carvalho,b Augusto César Aragão Oliveira,b Cláudia Pessoa,b Thaís Cristina Mendonça Nogueira,a Cristiane França da Costa,a and Marcus Vinícius Nora de Souza*,a,c   

  1. a Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, 21041-250, Rio de Janeiro, RJ, Brazil
    b Laboratório de Oncologia Experimental, Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Rodolfo Teófilo, 60430-275, Fortaleza, CE, Brazil
    c Universidade Federal do Rio de Janeiro, Instituto de Química, Departamento de Química Orgânica, CP 68563, 21945-970, Rio de Janeiro, RJ, Brazil
  • Received:2020-08-09 Revised:2020-09-30 Online:2020-12-20 Published:2020-12-20
  • Contact: marcus.nora@far.fiocruz.br (M. S.)
  • Supported by:

Abstract: Fourteen arenecarbaldehyde 2-pyridinylhydrazone derivatives have been synthesized and evaluated for their cytotoxic potential against four cancer cell lines using the MTT assay. The products were characterized by 1H NMR, 13C NMR, and HRMS, and the cytotoxicity results were expressed as the concentration that induced 50% inhibition of cell growth (IC50) in μM. The most active compound was 2-pyridinecarbaldehyde 2-pyridinylhydrazone, with an IC50 value of 0.96 μM, which displayed potent and selective activity against the human prostate cancer cell line, PC3, similar to the antineoplastic drug doxorubicin.

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