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Synthesis and Cytotoxic Activity of Arenecarbaldehyde 2-Pyridinylhydrazone Derivatives
Alessandra Campbell Pinheiro, Sarah Sant’Anna Maranhão, Guilherme Graziany Camelo Carvalho, Augusto César Aragão Oliveira, Cláudia Pessoa, Thaís Cristina Mendonça Nogueira, Cristiane França da Costa, Marcus Vinícius Nora de Souza
Medicine Research    DOI: 10.21127/yaoyimr20200016
Online available: 15 October 2020

An Effective Inhibitory of Triptolide on Ovarian Cancer
Xiaodi Li, Rui Liu, Ping Wang, and Jun Zhu
Medicine Research    DOI: 10.21127/yaoyimr20200017
Online available: 15 November 2020

Metal Complexes of Thiosemicarbazones as Potent Anticancer Agents: a Minireview
Yue Zhao, Lijun Wang, Chuanlong Guo, Bo Jiang, Xiangqian Li, Kun Liu, Dayong Shi
Medicine Research    2018, 2 (2): 180009-.   DOI: 10.21127/yaoyimr20180009
Abstract242)   HTML23)    PDF (500KB)(290)       Save

As cancer is one of humanity’s biggest killers in the world, scientists have been looking for different drugs as agents to treat cancer. However, current chemotherapeutics is not sufficiently effective. Thiosemicarbazone complexes of transition metals have attracted wide attention due to a great effect of anticancer activity with different mechanisms including ribonucleotide reductase inhibition, metal dependent radical damage, DNA binding, and inhibition of protein synthesis, and so on. In this minireview, we summarize different metal chelators of thiosemicarbazones and their anticancer mechanisms, which are useful for the development of thiosemicarbazone as anticancer drugs.

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Adverse Reactions and Resistance of Anticancer Drug Cisplatin
Zhonglie Yang, Li Lin, Xiaoyan Peng, Xinyi Yu, Xiaobin Zhang, Hezhong Jiang, and Jiahong Li
Medicine Research    DOI: 10.21127/yaoyimr20200022
Online available: 08 March 2021

Recent Advances on Small-Molecule Tubulin Inhibitors
Xiu-Li Sun, Yin-Rong Xie, Ning Zhang, Cheng-Ting Zi, Xuan-Jun Wang, and Jun Sheng
Medicine Research    DOI: 10.21127/yaoyimr20200024
Online available: 08 March 2021

Recent Advances on Small-Molecule Epidermal Growth Factor Receptor Inhibitors
Bo-Ya Shi, Ze-Hao Wang, Xuan-Jun Wang Jun Sheng, and Cheng-Ting Zi
Medicine Research    2020, 4 (3): 200011-.   DOI: 10.21127/yaoyimr20200011
Abstract356)      PDF (418KB)(247)       Save
The epidermal growth factor receptor (EGFR) is a kind of cell membrane surface receptor with tyrosine kinase activity, which is closely related to the growth, proliferation, differentiation, apoptosis, metastasis and other processes of tumor cells. Targeting EGFR tyrosine kinase inhibitors has become a hot topic for drug development for treatment of non-small-cell cancer (NSCLC). Herein, we summarized recent advances on the targeted therapeutic drugs for NSCLC in recent years.
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Progress in Antitumor Activity of Diterpenoid Alkaloids
Xiao-Jing Shen, Ting-Ting Zheng, Hong Wang, Jiao Cai, Cheng-Ting Zi, and Jiang-Ping Fan
Medicine Research    DOI: 10.21127/yaoyimr20200015
Online available: 11 November 2020

Recent Advances on Interaction Targets for Anticancer Activity of Caffeine
Titi Liu, Chengting Zi, Xuanjun Wang, Jun Sheng, and Huanhuan Xu
Medicine Research    DOI: 10.21127/yaoyimr20200020
Online available: 26 January 2021

Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms
Chunxia Gan, Chengting Zi, Jun Sheng, Xuanjun Wang, and Huanhuan Xu
Medicine Research    2021, 5 (2): 210006-210006.  
Abstract154)      PDF (629KB)(179)       Save
Skin is the largest human organ, which always suffered from environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin can take different protective mechanisms to maintain balance, excessive stresses can disrupt these systems, resulting in the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Phytochemicals are biologically active compounds derived from plants and herbal products, which appear to be beneficial in the battle against cancer as they exhibit anti-cancer effects and are inexpensive, widely available, and well tolerated. Studies have demonstrated that phytochemicals can act on various cellular processes including cell cycle, apoptosis and redox metastasis to inhibit the development and progression of skin cancer. This article mainly focuses on the progress in anti-skin cancer activity of phytochemicals and underlying molecular mechanisms, which will hopefully provide valuable insights into clinical applications of phytochemicals for treatment of skin cancers.
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