Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms

Abstract

Abstract: Skin is the largest human organ, which always suffered from environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin can take different protective mechanisms to maintain balance, excessive stresses can disrupt these systems, resulting in the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Phytochemicals are biologically active compounds derived from plants and herbal products, which appear to be beneficial in the battle against cancer as they exhibit anti-cancer effects and are inexpensive, widely available, and well tolerated. Studies have demonstrated that phytochemicals can act on various cellular processes including cell cycle, apoptosis and redox metastasis to inhibit the development and progression of skin cancer. This article mainly focuses on the progress in anti-skin cancer activity of phytochemicals and underlying molecular mechanisms, which will hopefully provide valuable insights into clinical applications of phytochemicals for treatment of skin cancers.

Key words: skin, skin cancer, phytochemicals, anti-cancer, molecular mechanisms

Chunxia Gan, Chengting Zi, Jun Sheng, Xuanjun Wang, and Huanhuan Xu. Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms[J]. Medicine Research, 2021, 5(2): 210006-210006.

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