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Medicine Research ›› 2024, Vol. 8 ›› Issue (1): 230010-230010.DOI: 10.21127/yaoyimr20230010

• Perspectives • Previous Articles     Next Articles

A Perspective of 6,12-Guaianolides and Their Analogues: Synthesis, Bioactivity and Structure-Activity Relationships

Ruihua Guoa,*, Guo Y. Yinb, Ruilong Shengc,*   

  1. aCollege of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China;
    b10132 Baylee Ln, San Diego, CA 92127, United States;
    cCQM - Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
  • Received:2023-10-06 Accepted:2023-11-28 Online:2024-03-20 Published:2024-04-25
  • Contact: Email: rhguo@shou.edu.cn (R. G.); ruilong.sheng@staff.uma.pt (R. S.)

Abstract: Recently, the study on 6,12-guaianolides, a family of natural guaiane-type sesquiterpenoids, has attracted increased attention in the field of chemical synthesis, pharmaceutics, and medicinal chemistry. Many 6,12-guaianolide compounds and their analogues showed remarkable molecular diversity, structural modifiability, and versatile biological and pharmacological properties, such as anticancer, antivirus, anti-inflammatory, endogenous NO production inhibition, and so on. In this paper, we summarized recent advances on the synthesis methods of 6,12-guaianolides and their analogues, briefly described their bioactivities, and elucidated the quantitative structure-activity relationship of some 6,12-guaianolides and their analogues. Furthermore, the perspectives of 6,12-guaianolides and their analogues were discussed.

Key words: guaiane-type sesquiterpenoids, cytotoxicity, NO inhibition, quantitative structure-activity relationship

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