A Perspective of 6,12-Guaianolides and Their Analogues: Synthesis, Bioactivity and Structure-Activity Relationships

doi:10.21127/yaoyimr20230010

Abstract

Abstract: Recently, the study on 6,12-guaianolides, a family of natural guaiane-type sesquiterpenoids, has attracted increased attention in the field of chemical synthesis, pharmaceutics, and medicinal chemistry. Many 6,12-guaianolide compounds and their analogues showed remarkable molecular diversity, structural modifiability, and versatile biological and pharmacological properties, such as anticancer, antivirus, anti-inflammatory, endogenous NO production inhibition, and so on. In this paper, we summarized recent advances on the synthesis methods of 6,12-guaianolides and their analogues, briefly described their bioactivities, and elucidated the quantitative structure-activity relationship of some 6,12-guaianolides and their analogues. Furthermore, the perspectives of 6,12-guaianolides and their analogues were discussed.

Key words: guaiane-type sesquiterpenoids, cytotoxicity, NO inhibition, quantitative structure-activity relationship

Ruihua Guo, Guo Y. Yin, Ruilong Sheng. A Perspective of 6,12-Guaianolides and Their Analogues: Synthesis, Bioactivity and Structure-Activity Relationships[J]. Medicine Research, 2024, 8(1): 230010-230010.

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