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Medicine Research ›› 2024, Vol. 8 ›› Issue (1): 230006-230006.DOI: 10.21127/yaoyimr20230006

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The Effect and Underlying Mechanism of Sleep Deprivation on Several Gastrointestinal Physiology and Diseases

Yi-Fan Li, Lu-Yu Niu, Jie-Fu Fan, Zhi-Chao Yao, Ling-Yun Shen, Yang-Kai Wang*, Ying He*   

  1. Naval Medical Center of People's Liberation Army of China, Naval Medical University(Second Military Medical University), Shanghai 200433, China
  • Received:2023-08-21 Revised:2023-08-28 Accepted:2023-09-01 Online:2024-03-20 Published:2024-04-25
  • Contact: Email: wyangkai2005@smmu.edu.cn (Y. W.), yinghe_hys@163.com (Y. H.)

Abstract: The incidence of sleep deprivation has increased significantly in contemporary society. Gastrointestinal diseases, one of the diseases with high incidence caused by sleep deprivation, are increasingly becoming a serious public health threat worldwide. However, confusion about underlying mechanism by which sleep deprivation exacerbates gastrointestinal dysfunction has always hindered people from carrying out effective clinical treatment. In this paper, we review the effects of sleep deprivation on four gastrointestinal physiology and further reveal the mechanism by which sleep deprivation exacerbates several gastrointestinal diseases, providing a new perspective for people to better understand and treat related diseases.

Key words: sleep deprivation, gastrointestinal physiology, gastrointestinal disorder, circadian rhythm, clock gene

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