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Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis
Tao-Tao Xue, Hong-Bo Xu, Zhi-Shu Tang, Jin-Ao Duana, Hong-Bo Liu, Xin-Bo Shi, and Zhong-Xing Song
Medicine Research    2021, 5 (2): 210002-210002.   DOI: 10.21127/yaoyimr20210002
Abstract487)      PDF (717KB)(779)       Save
Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.
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Flavonoids Isolated from the genus Ficus and Their Biological Activities
Yaxian Zhao, Jing Niu, Qinru Zhou, Yan Chen, Shiquan Gan, Xiangchun Shen, Nenling Zhang
Medicine Research    2021, 5 (2): 210004-210004.   DOI: 10.21127/yaoyimr20210004
Abstract403)      PDF (2171KB)(646)       Save
There are about 1000 species in the genus Ficus and many can be used for medicinal purpose. The medicinal plants of this genus mainly contain terpenoids, flavonoids, alkaloids, and coumarins. In this paper, we summarized flavonoids isolated from the genus Ficus and their pharmacological effects including anti-bacterial, anti-inflammatory, antitumor, antioxidant, antiviral, protective activities on the cardiovascular system and other activities.
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Progress in Chemical Constituents and Bioactivities  of  Perilla frutescens  (L.) Britt
Hui Fang, Shudan Zheng, Jifeng Liu
Medicine Research    2021, 5 (3-4): 210008-210008.   DOI: 10.21127/yaoyimr20210008
Abstract287)      PDF (744KB)(368)       Save
Perilla frutescens (L.) Britt is an annual herb of the genus Perilla in the labiaceae. Its leaves, stalks and fruits can be used as folk medicine. The chemical components in Perilla frutescens (L.) Britt can be divided into volatile oil, terpenoids, triterpenoids, steroids, glycosides, phenylpropanoids and phenolic acids, flavonoids and pigments, which have anti-allergy, antibacterial, hypolipidemia, antioxidation, antitumor, antitussive and antipyretic activities. In this paper, we reviewed research progress of chemical constituents and pharmacological effects of Perilla frutescens to provide new ideas for subsequent development of Perilla frutescens (L.) Britt.
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Recent Advances on Molecular Modeling Studies of Transient Receptor Potential Ankyrin 1
Carita Sallomy, Maija Lahtela-Kakkonen, and Juri M. Timonen
Medicine Research    DOI: 10.21127/yaoyigc20200021
Online available: 12 December 2020

Recent Advances on Small-Molecule Tubulin Inhibitors
Xiu-Li Sun, Yin-Rong Xie, Ning Zhang, Cheng-Ting Zi, Xuan-Jun Wang, and Jun Sheng
Medicine Research    DOI: 10.21127/yaoyimr20200024
Online available: 08 March 2021

Adverse Reactions and Resistance of Anticancer Drug Cisplatin
Zhonglie Yang, Li Lin, Xiaoyan Peng, Xinyi Yu, Xiaobin Zhang, Hezhong Jiang, and Jiahong Li
Medicine Research    DOI: 10.21127/yaoyimr20200022
Online available: 08 March 2021

Natural Products from the genus Daldinia and Their Bioactivities

Jing Li, Luohao Li, Runqing Zhu, Vuanghao Lim, Qianqian Sun, and Lizhen Fang
Medicine Research    2021, 5 (3-4): 210005-210005.   DOI: 10.21127/yaoyimr20210005
Abstract211)      PDF (1005KB)(398)       Save
Genus Daldinia is a unique source of natural products, which possess many pharmacological effects such as antibacterial activity, cytotoxicity, antioxidant activity, α-glucosidase inhibitory activity, and so on. Recently, most studies of genus Daldinia were focused on D.eschscholzii, D.concentrica and D.sp. This paper covers nearly a decade of research on Daldinia, focusing on the chemical structures and related biological activities of the secondary metabolites produced.
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Recent Advances on Interaction Targets for Anticancer Activity of Caffeine
Titi Liu, Chengting Zi, Xuanjun Wang, Jun Sheng, and Huanhuan Xu
Medicine Research    DOI: 10.21127/yaoyimr20200020
Online available: 26 January 2021

Oxaliplatin Induces Cell Cycle Arrest and Apoptosis in T-leukemia Cells through Mitochondrial and PI3K/Akt Signaling Pathways
Mengcheng Li, Yongpeng Wang, Lei Tian, Afsar Khan, Yudan Wang, Yaping Liu, Meilian Yang, Jianxin Cao, Guiguang Cheng, and Tianrui Zhao
Medicine Research    2021, 5 (2): 210003-210003.   DOI: 10.21127/yaoyimr20210003
Abstract208)      PDF (2460KB)(366)       Save
Oxaliplatin (L-OHP) is a new platinum anticancer drug, which is used for the treatment of metastatic colorectal cancer or the adjuvant treatment of stage III colon cancer. T-cell acute lymphoblastic leukemias (T-ALLs) are invasive thymocytic malignant tumors with poor prognosis. The purpose of this study was to evaluate the cytotoxic effect of L-OHP on human T-ALL cell lines MOLT-4, Jurkat, CCRF-CEM, and CEM/C1 cells. The CCK-8 method results showed that L-OHP significantly inhibited T-ALL cells proliferation. The inhibition of these T-ALL cells prolife by L-OHP seems to be related to the induction of cell cycle arrest. The effect of L-OHP on the cell cycle distribution of T-ALL cells varies with cell types. As to cells apoptosis, Annexin V/Propidium iodide assay disclosed that L-OHP prominently induced T-ALL cells apoptosis by activating the pathways of mitochondrial biogenesis and is more sensitive to MOLT-4 cells. Western blot analysis showed that L-OHP treatment could promote apoptosis through down-regulated Bcl-2 protein level, up-regulated Bax and caspase-9 proteins levels and cell cycle arrest by inhibiting the PI3K/Akt signaling pathway in MOLT-4 cells. Our results indicate that L-OHP, as a new type of platinum anticancer drug, may attract more attention in the future treatment of T-ALL.
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Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy
Zhao Wang, Filipe Olim, Jingjing Sun, Ana Rute Neves, Fátima Mendes, Helena Tomás, and Ruilong Sheng
Medicine Research    DOI: 10.21127/yaoyimr20200023
Online available: 08 February 2021

Recent Advances on Anti-skin Cancer Activity of Phytochemicals and Underlying Molecular Mechanisms
Chunxia Gan, Chengting Zi, Jun Sheng, Xuanjun Wang, and Huanhuan Xu
Medicine Research    2021, 5 (2): 210006-210006.  
Abstract197)      PDF (629KB)(216)       Save
Skin is the largest human organ, which always suffered from environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin can take different protective mechanisms to maintain balance, excessive stresses can disrupt these systems, resulting in the formation of skin cancers, including both melanoma and non-melanoma skin cancers. Phytochemicals are biologically active compounds derived from plants and herbal products, which appear to be beneficial in the battle against cancer as they exhibit anti-cancer effects and are inexpensive, widely available, and well tolerated. Studies have demonstrated that phytochemicals can act on various cellular processes including cell cycle, apoptosis and redox metastasis to inhibit the development and progression of skin cancer. This article mainly focuses on the progress in anti-skin cancer activity of phytochemicals and underlying molecular mechanisms, which will hopefully provide valuable insights into clinical applications of phytochemicals for treatment of skin cancers.
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Study on Chemical Constituents and Bioactivities from Eucalyptus globulus
Shudan Zheng, Hui Fang, Jifeng Liu
Medicine Research    2021, 5 (3-4): 210007-210007.   DOI: 10.21127/yaoyimr20210007
Abstract193)      PDF (1222KB)(409)       Save
Eucalyptus globulus ( E. globulus) is a tall timber tree of genus Eucalyptus (Myrtaceae), and it is mainly distributed in the southern and southwestern China. The dry fruits of E. globulus, called as ‘Yi-Kou-Zhong’ in Chinese, have been commonly used as a traditional Chinese medicine to treat in flammation, eczema, and influenza. Herein, we summarized the chemical constituents and bioactivities of the Eucalyptus globulus.
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Progress in Skin Care Efficacy of Lactoferrin
Tong Xie, Wu Qiao, Tinghan Jia, and Ken Kaku
Medicine Research    2022, 6 (1-2): 210015-210015.   DOI: 10.21127/yaoyimr20210015
Abstract180)      PDF (724KB)(160)       Save
Lactoferrin is an iron-binding glycoprotein with a variety of biological activities, including anti-inflammatory, antibacterial, antitumor, antiviral, whitening, repairing skin damage caused by inflammation, immune regulation, and osteogenic activity. As a protein with great development potential, lactoferrin is widely used in the fields of food, medicine and cosmetics. The effect of lactoferrin on the skin is particularly prominent, and it has the potential to be used as a new raw material for skin care products. Researchers have reviewed biological activities of lactoferrin and its microbial mechanism of action. Therefore, this article focuses on the skin care efficacy of lactoferrin. This article reviews the latest research results of lactoferrin in skin care efficacy.
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Progress in Terpenes from Genus  Paeonia
Lei Sun, Chuihao Kong, Huan Zhao, Deling Wu, Fengqing Xu
Medicine Research    2021, 5 (3-4): 210011-210011.   DOI: 10.21127/yaoyimr20210011
Abstract164)      PDF (637KB)(309)       Save
Paeonia is the single genus of ca. 35 known species in the family Paeoniaceae. Up to now, more than 185 terpenes have been isolated from root/root cortex, flowers and seeds of the genus Paeonia. Researches had focused on the following species, such as P. lactiflora, P. suffruticosa Andr, P. veitchii, P. labiflora, P. delavayi, P. rockii, P. emodi, P. peregrina, and P. japonica. In this paper, the terpenes of Paeonia were reviewed, which may provide more useful information for further development on this genus.
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Progress in Phytochemical and Bioactivities of Areca catechu L
Zhenshuai Tang, Jifeng Liu
Medicine Research    2022, 6 (3-4): 220004-220004.   DOI: 10.21127/yaoyimr20220004
Abstract163)      PDF (576KB)(158)       Save
Areca catechu L is a genus of plants whose leaves and fruits can be used as folk medicine. The chemical composition of A. catechu can be divided into alkaloids, flavonoids, tannins, terpenoids, sterols, fatty acids, etc. It has pharmacological effects such as anti-inflammatory, antioxidant, antibacterial, antidepressant, hypotensive, etc., while having toxic side effects such as oral toxicity, hepatotoxicity and addiction. This paper reviews the progress of research on chemical composition and pharmacological effects and toxic side effects of A. catechu, and provides new ideas for subsequent development of A. catechu.
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Recent Advances on Anticancer Effects and Molecular Mechanisms of Maslinic Acid
Jin Li, Xiaomei Yang, Wei Jiang, Qianqian Hu, Xuanjun Wang, Huanhuan Xu
Medicine Research    2022, 6 (3-4): 220002-220002.   DOI: 10.21127/yaoyimr20220002
Abstract163)      PDF (482KB)(159)       Save
Cancer has become a serious public health concern that affects millions of individuals annually in the world. Surgical resection, chemotherapy and radiotherapy have been considered as the standard treatment strategies for different kinds of cancers. Among them, chemotherapeutic agents are usually used for the treatment of malignancies but toxic side effects and drug resistance limit their clinical efficacy. Natural compounds isolated from medicinal plants are excellent and reliable sources of new anticancer drugs. Maslinic acid is a naturally occurred pentacyclic triterpenoid with anticancer activities. This review mainly focuses on recent advances on anticancer effects and molecular mechanisms of maslinic acid and will hopefully provide valuable insights into clinical application of maslinic acid to the treatment of cancers.
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Recent Advances on Drug Treatments of Rheumatoid Arthritis
Chunxia Gan, Mingzhen Yu, Ergu Chen, Xuanjun Wang, Huanhuan Xu
Medicine Research    2022, 6 (1-2): 210012-210012.   DOI: 10.21127/yaoyimr20210012
Abstract155)      PDF (565KB)(144)       Save
Rheumatoid arthritis is a chronic autoimmune disorder caused by persistent activation of immune system. Rheumatoid arthritis is the most prevalent form of inflammatory arthritis and always has critical consequences to the joints. Reducing pain, decreasing inflammation and blocking immune response are the main ideas for the treatment of rheumatoid arthritis. There are several therapeutic drugs are available for rheumatoid arthritis: nonsteroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biologic anti-rheumatic drugs. All these drugs are used alone or in combination with methotrexate, which have produced a remarkable impact on the occurrence and development of rheumatoid arthritis. Herein, we summarized the treatment options and some new drugs.
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Progress in Chemical Constituents and Pharmacological Effects of Lindera obtusiloba Bl
Hong Zhou, Qingtian Gao, Jisong Mo, Jimin Liu, Na Pan, Chunyi Duan, Xin Chen , Hezhong Jiang
Medicine Research    2021, 5 (3-4): 210010-210010.   DOI: 10.21127/yaoyimr20210010
Abstract146)      PDF (672KB)(221)       Save
Lindera obtusiloba Bl belongs to the genus Lindera, which has a long history of medicinal use and a wide range of uses. It has many significant physiological activities such as improving blood circulation, treating inflammation and preventing liver injury. Investigations about the chemical compounds of L. obtusiloba have shown that its main compounds include butyrolactones, lignans, flavonoids, phytosterols, volatile oils and phenolic glycosides, with antibacterial, anti-inflammatory, cytotoxicity, anti-oxidation and anti-fibrosis activities. At present, there are few reports on its chemical constituents and physiological activities. Herein, we summarized the reported chemical constituents and physiological activities of L. obtusiloba and laid a foundation for further research.
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Chemical Constituents and Bioactivities of Aconitum episcopale
Xiaojing Shen, Hong Wang, Jiao Cai, Zhubin Zhou, and Fanqiu Nie
Medicine Research    2021, 5 (2): 210001-210001.   DOI: 10.21127/yaoyimr20210001
Abstract138)      PDF (872KB)(327)       Save
Aconitum episcopale Levl., known as a characteristic Aconitum specie in China, is a perennial herbaceous plant classified into Aconitum L. (Ranunculaceae), which mainly distributes in northwest Yunnan and southwestern Sichuan. As a commonly traditional Chinese medicine, the root of A. episcopale has been used to treat anemofrigid-damp arthralgia, arthralgia, cold hernia and anesthesia analgesia with the effects of expelling wind and removing damness, warming menstruation and relieving pain. It also is used for solving other Aconitums poisoning in folk. In order to obtain more information for research and development of A. episcopale, the chemical components and pharmacological research on A. episcopale were reviewed. It is beneficial for future research, development and utilization of Aconitum and search for traditional herbal resources.
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Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis
Xuewei Wang, Yanqing Yang, Yan Li, Chaofei Ba
Medicine Research    2022, 6 (1-2): 220001-220001.   DOI: 10.21127/yaoyimr20220001
Abstract128)      PDF (606KB)(113)       Save
Loss of retinal ganglion cells (RGCs) is the main cause of glaucoma and traumatic optic neuropathy, which can eventually lead to optic nerve atrophy and vision loss. Acteoside is a natural phenylpropanoid glycoside compound with many pharmacological activities, including neuroprotective effects. Studies have shown that acteoside can protect RGCs from damage; however, the underlying mechanism remains unclear. In this paper, we investigated whether acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis. H & E staining showed that acteoside treatment significantly attenuated RGC damage in acute high intraocular pressure-induced rats. Additionally, immunohistochemical staining and immunoblotting analysis demonstrated that acteoside treatment significantly inhibited the expression of Bax and increased the expression of Bcl-xL in retina tissues. Collectively, these findings demonstrate that acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis, suggesting that acteoside has a promising potential in glaucoma treatment.
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SARS-CoV-2 Inactivation by Persulfate-Enhanced Silver Ions
Jingyao Zhu, Shuhong Wu, Yanwen Fang, Lin Lin, Jun Zhu
Medicine Research    2022, 6 (1-2): 210013-210013.   DOI: 10.21127/yaoyimr20210013
Abstract121)      PDF (428KB)(102)       Save
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health concern with over 100 million confirmed cases. Considering the pandemic emergency, new safety strategies must be found against SARS-CoV-2 virus. In present study, a persulfate-enhanced silver ion is obtained against SARS-CoV-2, evidencing its potential as an efficient and rapid alternative for controlling viral spread. The synergistic interacting between Ag + and K 2S 2O 8 is proposed, which means that K 2S 2O 8 can oxidize +1 of silver ions to a higher valance state and can produce highly oxidative sulfate radical anions (SO 4-) for a kind of compound disinfectant with silver ions. The persulfate-enhanced silver ion has 99.54% of Anti-SARS- CoV-2 viral activity at a low concentration of 100 ppm and 99.999%, 99.999% and 99.99% of the killing effect on Escherichia coli, Staphylococcus aureus and Candida albicans at a lower concentration of 30 ppm and a short time of 0.5 min. Thus, the obtained materials may be made available for hand hygiene and for disinfection of surfaces, washing equipment of individual protection in hospitals and laboratories, as well as for household use.
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Preparation of Ti Doped Nano-ZnO Dispersion and Their Application in Deodorization and Antibiosis
Lin Lin, Shuhong Wu, Xiaoyan Wu, Zheng Zhu, Yongxin Wu, Jun Zhu
Medicine Research    2022, 6 (3-4): 220003-220003.   DOI: 10.21127/yaoyimr20220003
Abstract114)      PDF (873KB)(84)       Save
To develop an effective deodorant and antibacterial agent, we prepare a Ti doped nano-ZnO through a low temperature hydrothermal route. The shape and size of these as-prepared samples can be tuned effectively by controlling the reaction conditions, such as the molar ratio of Ti/Zn. Furthermore, the sample with an appropriate portion of Ti and Zn is selected to obtain dispersion for improving sample activity and avoiding sample agglomeration. XRD, SEM, EDX and DLS are performed to characterize the structure and morphology of samples. Furthermore, the typical dispersion is used to remove odorous molecules and kill bacteria. The results show that polycarboxylic acid can be used to improve the dispersibility and stability of nanoparticles, and the well-dispersed dispersion is high effective for deodorization and antibiosis. Moreover, CCK-8 assays are performed to evaluate the cytotoxicity of dispersions with different size. The result reveals that dispersion with a smaller particle size displayed more serious toxicity. Thus, we suggest that the obtained dispersion can be used as a deodorant and antibacterial agent, but it is necessary to take precautions when handling the dispersion because the nanoparticles, special smaller nanoparticles is more likely to cause serious cytotoxicity.
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Chemical Research on Limonoids Isolated from the Fruits of Melia toosendan
Hao Wang, Hao-Yan Dong, Yan-Fang Liu, Yu-Xiang Ma, Wei Wang, Zhi-Mou Guo and Chao-Ran Wang
Medicine Research    2022, 6 (1-2): 210014-210014.   DOI: 10.21127/yaoyimr20210014
Abstract109)      PDF (1100KB)(177)       Save
As the characteristic components from the fruits of Melia toosendan, limonoids attract continuous research interest for their chemistry and biodiversity, and their analogues are continuously obtained from this plant. Thus, limonoids isolated from the fruits of M. toosendan were investigated, classified and the biogenic metabolic pathway were supposed to provide more information for further research on the title plant.
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Pharmacist Intervention with Computer-Based Alert System and Assessment of Prescription Errors for Outpatient in a Chinese Tertiary Hospital
Qing Shen, Yi-Meng Zhou, Jin Lv, Hua Yang, Yuan-yuan He, Yuan Bian, Yong Han
Medicine Research    2021, 5 (3-4): 210009-210009.   DOI: 10.21127/yaoyimr20210009
Abstract108)      PDF (639KB)(218)       Save
Qualified prescribing is fundamental for appropriate use of medicine. Pharmacist interventions potentially remind physicians to cope with this issue. This study aimed to report interventions implemented by pharmacists with real-time computer-based alert system and evaluate the prescription errors for outpatients in a Chinese tertiary hospital. This retrospective, non-comparative study was implemented with an analysis of data collected from October to December in 2018 involved all clinical specialty departments in the hospital. Alerts were generated and displayed on pharmacist screen while prescribing inappropriately, then pharmacists chose certain operation and offered recommendations according to the alerts. Outcomes such as category and acceptance rate of pharmacist recommendations, prescription error types, prevalence rate, severity level and monthly tendency were documented, categorized and analyzed. In our study, 2.3% of prescriptions generated alerts, and incidence of pharmacist interventions was 0.19%. 431 prescription errors were prevented, with the overall acceptance rate of interventions accounted for 29.7%. Dosage or frequency problems ( n = 170, 39.5%), contraindications ( n = 79, 18.3%) and improper duration of pharmacotherapy ( n = 53, 12.3%) were the top three types of prescription errors. Monthly rate of errors decreased from 0.98 to 0.43 per 1000 prescriptions in the monitoring period. Pharmacist interventions with computer-based alert system were available for filtering part of invalid alerts and preventing prescription errors in our study.
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Progress in Synthetic Methodology of Coumarins
Sijin Hang, Yinan Wang, Ruilong Sheng, Ruihua Guo
Medicine Research    2022, 6 (3-4): 220005-220005.   DOI: 10.21127/yaoyimr20220005
Abstract89)      PDF (1018KB)(104)       Save
The basic structure of coumarins contain a benzene ring and a pyrone ring, which drive their values on biological research and potential therapeutic properties. In recent years, the synthesis of coumarins and their derivatives have drawn much attention from organic chemists and medicinal chemists. Herein, we summarized recent advances on synthetic methodologies of coumarins from 2011 to 2021.
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Research Advances and Applications of Polysaccharide-Based Complex Hydrogels
Yuting Liu, Yunbo Ge, Chaoyan Zhang
Medicine Research    2023, 7 (1-2): 230005-230005.   DOI: 10.21127/yaoyimr20230005
Abstract60)      PDF (689KB)(29)       Save
This paper introduces research background of polysaccharide-based composite hydrogel materials, discusses definition, classification and preparation of hydrogels, and summarizes research progress of chitosan-based hydrogels, hyaluronic acid-based hydrogels, alginate-based hydrogels, starch-based hydrogels and cellulose-based hydrogels according to different types of polysaccharides. In addition, we summarize the applications of polysaccharide-based complex hydrogels in wound healing, tissue engineering, and drug delivery. Finally, the development opportunities and challenges faced by polysaccharide-based complex hydrogels are summarized, and the future research directions are prospected, hoping to broaden their potential application fields.
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Physicochemical Properties and in vitro Digestion Characteristics of Polysaccharide from Auricularia auricula
Min Lei, Yuting Liu, Yunbo Ge, Chaoyan Zhang
Medicine Research    2023, 7 (1-2): 230004-230004.   DOI: 10.21127/yaoyimr20230004
Abstract51)      PDF (640KB)(35)       Save
Auricularia auricula polysaccharide (AAP) was extracted with ethanol of different concentrations (50%, 60%, 70%, 80%, 90%). Taking the yield, total sugar content, and uronic acid content as the indexes, the optimal alcohol precipitation concentration of AAP was 50%, and the polysaccharide content was 58.89%. In vitro digestion experiment showed that the content of reducing sugar in AAP was almost unchanged in the saliva and gastric juice digestion phase. However, the reducing sugar content of AAP increased from 0.062 mg/mL at 0.5 h to 1.162 mg/mL at 3 h during the intestinal juice digestion phase. In addition, in vitro antioxidant results showed that AAP still maintained high 2,2’-azido bis (3-ethyl benzothiazole line-6-sulfonic acid) (ABTS) free radical scavenging activity after digestion.
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Antibacterial Activity of Extracellular Vesicles from Symbiotic Vaginal Lactobacilli
Lanxi Zheng, Kehai Liu*
Medicine Research    2023, 7 (1-2): 230003-230003.   DOI: 10.21127/yaoyimr20230003
Abstract44)      PDF (1093KB)(38)       Save
Vaginal microorganisms, dominated by Lactobacillus spp., are an important defense against infections including pathogenic sexually transmitted infections. Extracellular vesicles (EVs) are recognized and endocytosed by tissue cells through specific interactions between membrane surface proteins, and thereafter deliver their molecular cargo. Bacteria can use their EVs to interact with neighboring bacteria and play an important role in the physiology and pathogenesis of cells. Herein, we investigated whether the bacteriostatic effect of Lactobacillus was mediated by extracellular vesicles released by these bacteria. L. gasseri-derived EVs were isolated by ultracentrifugation and loaded with metronidazole to observe their antibacterial activity. Our results showed that L. gasseri-derived EVs could effectively encapsulate drug, enhanced drug retardation, and had good biosafety. EVs and EVs-metronidazole have inhibitory effects on E. coli, S. aureus, and L. monocytogenes, with the best inhibitory effect on L. monocytogenes. Together, our work provides a new potential strategy for vaginitis treatment.
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Contents: Med. Res. 1-2/2022
Medicine Research    2022, 6 (1-2): 0-.  
Abstract44)      PDF (464KB)(16)       Save
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Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease
Leandro Louback da Silva, Beatriz de Frias Leite, Emerson Teixeira da Silva, Marcus Vinícius Nora de Souza
Medicine Research    2023, 7 (1-2): 230002-230002.   DOI: 10.21127/yaoyimr20230002
Abstract41)      PDF (418KB)(25)       Save
Alzheimer's disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age of 85. It is responsible for incapacitation of the individual by degrading cognitive functions, and its evolution leads the individual to death after a few years. It is characterized by brain degeneration triggered by several factors. One of the triggering factors is in the acetylcholine system. There is a decrease in the count of this neurotransmitter in individuals with this disease. The involvement of endogenous metal ions such as iron, copper, and zinc has also been involved in neurodegeneration mechanisms, in which there is the formation of radical species that cause oxidative stress, with important contribution of the neutrophil-derived enzyme myeloperoxidase, forming lesions in the neuronal cytoplasm and functional deficiency of neurons. In the present work, we report the evaluation of seventeen Camphor hydrazone derivatives 3a—3q, prepared in accordance with our previous work, as probable inhibitors of myeloperoxidase (MPO), acetylcholinesterase (AChE), and free radical-scavenging, to be used as potential agents against AD. Nine compounds showed significant activity against MPO. Among them, 3j and 3k had 78.4 and 53.9 μM (IC 50), respectively. Three compounds showed stronger activity, 3d, 3k, and 3l with EC 50 of 15.2, 21.3, and 14.4 µM, respectively, for free radical-scavenging activity, being similar to the standard quercetin (12.8 µM). All the final compounds were analyzed for drug-likeness. With exception for 3e and 3p, all were suitable on all filters evaluated. These results show that the compounds of hydrazone class are promising in the search for potential candidates for new agents against AD.
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Contents: Med. Res. 3-4/2022
Medicine Research    2022, 6 (3-4): 0-.  
Abstract36)      PDF (288KB)(18)       Save
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Contents: Med. Res. 1-2/2023
Medicine Research    2023, 7 (1-2): 0-0.  
Abstract30)      PDF (297KB)(11)       Save
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