[1] Egawa N.; Egawa K.; Griffin H.; Doorbar, J. Human papillomaviruses; epithelial tropisms, and the development of neoplasia. Viruses2015, 7, 3863-3890. [2] Yuan, Y.; Cai, X.; Shen, F.; Ma, F. HPV post-infection microenvironment and cervical cancer. Cancer Lett. 2021, 497, 243-254. [3] Kyrgiou M.; Moscicki A. B. Vaginal microbiome and cervical cancer. Semin. Cancer Biol.2022, 86, 189-198. [4] Qingqing B.; Jie Z.; Songben Q.; Juan C.; Lei Z.; Mu, X. Cervicovaginal microbiota dysbiosis correlates with HPV persistent infection. Microb. Pathog.2021, 152, 104617. [5] Ravel J.; Gajer P.; Abdo Z.; Schneider G. M.; Koenig S. S.; Mcculle S. L.; Karlebach S.; Gorle R.; Russell J.; Tacket C. O.; Brotman R. M.; Davis C. C.; Ault K.; Peralta L.; Forney, L. J. Vaginal microbiome of reproductive-age women. Proc. Natl. Acad. Sci. U. S. A.2011, 108 (Suppl. 1), 4680-4687. [6] Zhou Z.; Hou Y.; Qing W.; Shi Y.; Zhang Y.; Chen R.; Ou J.; Zhou H.; Chen M. The association of hpv infection and vaginal microbiota of reproductive women in china: A multicenter cohort study protocol. Med. Microecol.2023, 15, 100072. [7] Tachedjian G.; Aldunate M.; Bradshaw C. S.; Cone, R. A. The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Res. Microbiol.2017, 168, 782-792. [8] Mcmillan A.; Dell M.; Zellar M. P.; Cribby S.; Martz S.; Hong E.; Fu J.; Abbas A.; Dang T.; Miller W.; Reid, G. Disruption of urogenital biofilms by lactobacilli. Colloids Surf. B Biointerfaces2011, 86, 58-64. [9] Parolin C.; Marangoni A.; Laghi L.; Foschi C.; Nahui Palomino R. A.; Calonghi N.; Cevenini R.; Vitali B. Isolation of vaginal lactobacilli and characterization of anti-Candida activity. PLoS One2015, 10, e0131220. [10] Zhang, Y.; Liu, Y.; Liu, H.; Tang, W. H. Exosomes: Biogenesis, biologic function and clinical potential. Cell Biosci. 2019, 9, 2-18. [11] De Jong O. G.; Kooijmans S. a. A.; Murphy D. E.; Jiang L.; Evers M. J. W.; Sluijter J. P. G.; Vader P.; Schiffelers, R. M. Drug delivery with extracellular vesicles: From imagination to innovation. Acc. Chem. Res.2019, 52, 1761-1770. [12] Jahromi L. P.; Fuhrmann, G. Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharm- aceuticals. Adv. Drug Deliv. Rev.2021, 173, 125-140. [13] Brown, L.; Wolf, J. M.; Prados-Rosales, R.; Casadevall, A. Through the wall: Extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi. Nat. Rev. Microbiol. 2015, 13, 620-630. [14] Zhao Y.; Li X.; Zhang W.; Yu L.; Wang Y.; Deng Z.; Liu M.; Mo S.; Wang R.; Zhao J.; Liu S.; Hao Y.; Wang X.; Ji T.; Zhang L.; Wang C.Trends in the biological functions and medical applications of extracellular vesicles and analogues. Acta Pharm. Sin. B 2021, 11, 2114-2135. [15] Escude Martinez De Castilla, P.; Tong L.; Huang C.; Sofias A. M.; Pastorin G.; Chen X.; Storm G.; Schiffelers R. M.; Wang, J. W. Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies. Adv. Drug Deliv. Rev.2021, 175, 113801. [16] Kim J. H.; Lee J.; Park J.; Gho Y. S. Gram-negative and Gram-positive bacterial extracellular vesicles. Semin. Cell Dev. Biol.2015, 40, 97-104. [17] Behzadi E.; Mahmoodzadeh Hosseini H.; Imani Fooladi, A. A. The inhibitory impacts of Lactobacillus rhamnosus GG-derived extracellular vesicles on the growth of hepatic cancer cells. Microb. Pathog.2017, 110, 1-6. [18] Dean S. N.; Leary D. H.; Sullivan C. J.; Oh E.; Walper S. A. Isolation and characterization of Lactobacillus-derived membrane vesicles. Sci. Rep.2019, 9, 877. [19] Li M.; Lee K.; Hsu M.; Nau G.; Mylonakis E.; Ramratnam, B. Lactobacillus-derived extracellular vesicles enhance host immune responses against vancomycin-resistant enterococci. BMC Microbiol.2017, 17, 66. [20] Dean S. N.; Rimmer M. A.; Turner K. B.; Phillips D. A.; Caruana J. C.; Hervey W. J. T.; Leary D. H.; Walper, S. A. Lactobacillus acidophilus membrane vesicles as a vehicle of bacteriocin delivery. Front. Microbiol.2020, 11, 2-8. [21] Kim W.; Lee E. J.; Bae I. H.; Myoung K.; Kim S. T.; Park P. J.; Lee K. H.; Pham A. V. Q.; Ko J.; Oh S. H.; Cho, E. G. Lactobacillus plantarum-derived extracellular vesicles induce anti-inflammatory M2 macrophage polarization in vitro. J. Extracell. Vesicles2020, 9, 1793514. [22] Nahui Palomino R. A.; Vanpouille C.; Laghi L.; Parolin C.; Melikov K.; Backlund P.; Vitali B.; Margolis, L. Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues. Nat. Commun.2019, 10, 5656. [23] Dash M.; Palaniyandi K.; Ramalingam S.; Sahabudeen S.; Raja N. S. Exosomes isolated from two different cell lines using three different isolation techniques show variation in physical and molecular characteristics. Biochim. Biophys. Acta Biomembr.2021, 1863, 183490. [24] Shi Y.; Zhang R.; Da N.; Wang Y.; Yang J.; Li B.; He, X. Aspirin loaded extracellular vesicles inhibit inflammation of macrophages via switching metabolic phenotype in periodontitis. Biochem. Biophys. Res. Commun.2023, 667, 25-33. [25] Ruzycka-Ayoush M.; Nowicka A. M.; Kowalczyk A.; Gluchowska A.; Targonska A.; Mosieniak G.; Sobczak K.; Donten M.; Grudzinski, I. P. Exosomes derived from lung cancer cells: Isolation, characterization, and stability studies. Eur. J. Pharm. Sci.2023, 181, 106369. [26] Mathieu, M.; Nevo, N.; Jouve, M.; Valenzuela, J. I.; Maurin, M.; Verweij, F. J.; Palmulli, R.; Lankar, D.; Dingli, F.; Loew, D.; Rubinstein, E.; Boncompain, G.; Perez, F.; Thery, C. Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9. Nat. Commun. 2021, 12, 4389. [27] Brusselaers N.; Shrestha S.; Van De Wijgert J.; Verstraelen H. Vaginal dysbiosis and the risk of human papillomavirus and cervical cancer: Systematic review and meta-analysis. Am. J. Obstet. Gynecol.2019, 221, 9-18. [28] Wang K. D.; Xu D. J.; Wang B. Y.; Yan D. H.; Lv Z.; Su, J. R. Inhibitory effect of vaginal Lactobacillus supernatants on cervical cancer cells. Probiotics Antimicrob. Proteins2018, 10, 236-242. [29] Selle K.; Klaenhammer T. R. Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. FEMS Microbiol. Rev.2013, 37, 915-935. [30] Mathieu M.; Martin-Jaular L.; Lavieu G.; Thery C. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat. Cell Biol.2019, 21, 9-17. [31] Anand, D.; Chaudhuri, A. Bacterial outer membrane vesicles: New insights and applications. Mol. Membr. Biol. 2016, 33, 125-137. [32] Lee E. Y.; Choi D. Y.; Kim D. K.; Kim J. W.; Park J. O.; Kim S.; Kim S. H.; Desiderio D. M.; Kim Y. K.; Kim K. P.; Gho, Y. S. Gram-positive bacteria produce membrane vesicles: Proteomics-based characterization of Staphylococcus aureus- derived membrane vesicles. Proteomics2009, 9, 5425-5436. [33] Dominguez Rubio A. P.; Martinez J. H.; Martinez Casillas D. C.; Coluccio Leskow F.; Piuri M.; Perez, O. E. Lactobacillus casei BL23 produces microvesicles carrying proteins that have been associated with its probiotic effect. Front. Microbiol.2017, 8, 1783. [34] Goje O.; Shay E. O.; Markwei M.; Padmanabhan R.; Eng, C. The effect of oral metronidazole on the vaginal microbiome of patients with recurrent bacterial vaginosis: A pilot investigational study. Human Microbiome J.2021, 20, 100081. [35] Haurat, M. F.; Elhenawy, W.; Feldman, M. F. Prokaryotic membrane vesicles: New insights on biogenesis and biological roles. Biol. Chem. 2015, 396, 95-109. [36] Macdonald I. A.; Kuehn M. J. Offense and defense: Microbial membrane vesicles play both ways. Res. Microbiol.2012, 163, 607-618. |