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Medicine Research ›› 2023, Vol. 7 ›› Issue (1-2): 230003-230003.DOI: 10.21127/yaoyimr20230003

• Reports • Previous Articles     Next Articles

Antibacterial Activity of Extracellular Vesicles from Symbiotic Vaginal Lactobacilli

Lanxi Zheng, Kehai Liu*   

  1. Department of Biopharmaceutics, College of Food Science and Technology, Shanghai Ocean University, No. 999, Huchenghuan Road, Shanghai 201306, China
  • Received:2023-06-09 Revised:2023-06-15 Accepted:2023-06-20 Online:2023-06-20 Published:2023-09-01
  • Contact: Email: khliu@shou.edu.cn (K. L.)

Abstract: Vaginal microorganisms, dominated by Lactobacillus spp., are an important defense against infections including pathogenic sexually transmitted infections. Extracellular vesicles (EVs) are recognized and endocytosed by tissue cells through specific interactions between membrane surface proteins, and thereafter deliver their molecular cargo. Bacteria can use their EVs to interact with neighboring bacteria and play an important role in the physiology and pathogenesis of cells. Herein, we investigated whether the bacteriostatic effect of Lactobacillus was mediated by extracellular vesicles released by these bacteria. L. gasseri-derived EVs were isolated by ultracentrifugation and loaded with metronidazole to observe their antibacterial activity. Our results showed that L. gasseri-derived EVs could effectively encapsulate drug, enhanced drug retardation, and had good biosafety. EVs and EVs-metronidazole have inhibitory effects on E. coli, S. aureus, and L. monocytogenes, with the best inhibitory effect on L. monocytogenes. Together, our work provides a new potential strategy for vaginitis treatment.

Key words: Lactobacillus gasseri, extracellular vesicles, antibacterial activity, metronidazole

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