Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact Us
Early Edition  //  Current Issue  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited

Medicine Research ›› 2018, Vol. 2 ›› Issue (2): 180005-.DOI: 10.21127/yaoyimr20180005

• Report • Previous Articles     Next Articles

Controlled Imaging and Gene Transfection by Ultrasound Through a Positive Liposome

Rui Liua,Xinyi Zhangab,Dannong Hea*()   

  1. a National Engineering Research Center for Nanotechnology, 28 East Jiang Chuan Road, Shanghai 200241, China
    b School of Materials Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
  • Received:2018-06-20 Accepted:2018-07-02 Online:2018-06-30 Published:2018-09-01
  • Contact: Dannong He


Ultrasound-mediated gene delivery is a kind of new method of gene delivery because ultrasound given a certain dose of irradiation can reversibly change the morphology of the cell membrane. Thus, a gene carrier material is obtained through a positive liposome filled with CO2 gas and absorbed by DNA molecule, in which ultrasound-mediated gene delivery is established. Furthermore, the kind of new method of gene delivery is helpful for the dissociation of DNA molecules from liposome (LIP)/DNA complex and the cellular membrane permeability, which can increase SPCA-1 cell viability. Furthermore, the transfection efficiencies of LIP/DNA complex to cells are performed and the effect of ultrasonic time and intensity is further estimated.


Key words: positive liposome, ultrasound, gene delivery, transfection efficiency

Copyright © Medicine Research, All Rights Reserved.
Address: 425 East 76th Street, Apt 9E, New York, NY, 10021, United States