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Cover Illustration
2019, Vol.3  No.1
The cover picture shows an overview of triterpenes in the genus Ficus and their various bioactivities. More details are discussed in the article by Wang et al. on page 190004.

Online ISSN 2521-8743
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  • Table of Content
      20 March 2019, Volume 3 Issue 1 Previous Issue    Next Issue
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    Contents: Med. Res. 1/2019
    Medicine Research. 2019, 3 (1): 0.  
    Abstract   PDF (536KB) ( )
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    Interview with Professor Jun Zhu
    Jun Zhu
    Medicine Research. 2019, 3 (1): 198001.   DOI: 10.21127/yaoyimr20198001
    Abstract   PDF (140KB) ( )
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    New Songorine Derivatives as Novel G Protein-Coupled Receptor Antagonists: Syntheses and Preliminary Bioactivities Assay
    Jiangming Wang, Ruihua Guo
    Medicine Research. 2019, 3 (1): 190003.   DOI: 10.21127/yaoyimr20190003
    Abstract   PDF (820KB) ( )
    In our early screening process, songorine isolated from Aconitum brachypodum diels possessed prominent activity of inhibiting class B G protein-coupled receptors (GPCRs). For further study, a series of ester and carbonyl derivatives were synthesized and their potential inhibitory activities on class B GPCRs were also assayed by the Double Antibody Sandwich ELISA (DAS-ELISA) in vitro. Moreover, the structure-activity relationships (SARs) of songorine derivatives were discussed in detail. In this paper, the story behind this study was described.
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    Phytochemical and Biological Progress of Cynanchum paniculatum
    Liangyan Liu, Chang-An Geng
    Medicine Research. 2019, 3 (1): 190200.   DOI: 10.21127/yaoyimr20190200
    Abstract   PDF (881KB) ( )
    Cynanchum paniculatum (Xuchangqing) is a famous traditional Chinese herb (TCH) widely used for treating rheumatism and pains in China. C21 steroids and acetophenones are the characteristic constituents in this TCH, from which a total of 61 compounds have been reported involving 32 C21 steroids, 13 phenols, seven triterpenoids and nine other compounds. Biological investigation on this herb revealed the anti-inflammatory, anti-snake venom, anti-microbial, neuroprotective and anti-cancer properties of the pure compounds or crude extracts. This minireview summarized the phytochemical and biological progress of C. paniculatum to provide a reference for better understanding the effective substances of Xuchangqing.
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    Triterpenes from the genus Ficus and Their Bioactivities
    Qinru Zhou, Na Mao, Yan Chen, Shiquan Gan, Linjing Wu, Xiangchun Shen, Nenling Zhang
    Medicine Research. 2019, 3 (1): 190004.   DOI: 10.21127/yaoyimr20190004
    Abstract   PDF (1602KB) ( )
    Triterpenoids exist commonly in the genus Ficus. Till now, ninety-seven triterpenes have been isolated from the genus Ficus. The bioactivities of five triterpenes including maslinic acid, oleanolic acid, lupeol, betulinic acid and ursolic acid have been studied extensively. Herein, we provide an overview of triterpenes in the genus Ficus and their various bioactivities.
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    Phytochemical and Biological Progress of Ixeris sonchifoia (Bge.) Hance
    Tingyu Wen, Fang Li, Jifeng Liu
    Medicine Research. 2019, 3 (1): 190002.   DOI: 10.21127/yaoyimr20190002
    Abstract   PDF (919KB) ( )
    Ixeris sonchifoia (Bge.) Hance is a famous traditional Chinese herb (TCH) for medicinal treatment and diet with wide distribution and rich resources. Flavonoids, triterpenoids and sesquiterpene lactones are the characteristic constituents of this TCH. Biological investigation on I. sonchifoia revealed the remarkable pharmacological activities of this herb for the treatment of cardiovascular and cerebrovascular diseases. This review summarized the phytochemical and biological progress of I. sonchifoia to provide a reference for further research and development of this TCH.
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