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Medicine Research ›› 2020, Vol. 4 ›› Issue (1-2): 190010-190010.DOI: 10.21127/yaoyimr20190010

Special Issue: Marine Drugs

• Reports •     Next Articles

Renoprotective Effect of Sulphate Polysaccharide from Brown Algae on Ethylene Glycol-Induced Renal Damage in Rats

Hui Huanga,b, Junwen Wanga,b, Xueyan Lia,b, Wenhui Wua,b,c,d, Kejin Shi*,e, and Chaoyan Zhang*,a,b,c,d   

  1. a. College of Food Science and Technology, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China
    b. National Research Center for Freshwater Aquatic Products Processing Technology (Shanghai), Shanghai 201306, China
    c. Shanghai Aquatic Products Processing and Storage Engineering Technology Research Center, Shanghai 201306, China
    d. Laboratory of Quality and Safety of Aquatic Products Storage and Safety in Ministry of Agriculture, Shanghai 201306, China
    e. Sichuan Institute of antibiotics industry, Chengdu University, Chengdu, Sichuan 610052, China
  • Received:2019-11-27 Revised:2020-04-14 Online:2020-06-10 Published:2020-06-16
  • Contact: Kejin Shi,shikejin1228@163.com (K. S.), Chaoyan Zhang,chyzhang@shou.edu.cn (C. Z.)
  • Supported by:
    This work was funded by the Science and Technology Development Fund of Shanghai Ocean University (No. A2-0209-14-200069) and the Doctoral Research Fund of Shanghai Ocean University (No. A1-0209-13-0105394).

Abstract: The protective effect of the polysaccharides on ethylene glycol induced kidney impairment has been explored. Polysaccharides have been extracted from Sargassum graminifolium, which belongs to brown algae. Three different doses of polysaccharides were used for rats with kidney stones by ethylene glycol feeding. Then, urinary biochemistry parameters, renal function factors including blood urea nitrogen (BUN) and serum creatinine (Scr) levels were detected. Besides, interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) in kidney tissue were elevated, which belong to proinflammatory cytokines. Moreover, kidney histopathological sections were examined. The results illustrated that polysaccharides not only increased calcium level but also decreased oxalate, Scr, and BUN levels. In addition, the levels of IL-6 and TNF-α were reduced. Moreover, renal micro-scopic analysis showed polysaccharides treatment alleviated observably calcium oxalate deposits in the kidney tissue. The results indicated that the renoprotective mechanism of SGP may be attributed to suppression of inflammation, reducing the growth of urinary stones and improving kidney function in vivo, which explained SGP through multiple ways to protect kidney cells from damaging of hyperoxaluria rats.


Key words: brown algae, polysaccharides, hyperoxaluric, urinary stones, inflammation, antioxidants

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