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Medicine Research ›› 2019, Vol. 3 ›› Issue (3): 190008-0.DOI: 10.21127/yaoyimr20190008

Special Issue: Nanomedicine

• Review • Previous Articles     Next Articles

Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine

Zhaokun Zhang,†,a Yan Xu,†,*,b Kunfeng Zhao,*,a,b Ying Zhang,b Weijia Chen,c Xiaodi Li,d Yanxia Meng,a Dicheng Yang,b Ping Wang,b and Jun Zhu†,*,a,b   

  1. a School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
    b National Engineering Research Center for Nanotechnology, Shanghai 200241, China
    c School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
    d Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China
  • Received:2019-10-29 Revised:2019-11-21 Online:2019-12-20 Published:2020-02-01
  • Contact: Email: yxusinap@163.com (Y. X.), zhaokunfeng-gl@163.com (K. Z.), yzjzhu@163.com (J. Z.).
    These authors contributed equally to this work.
  • Supported by:
     

Abstract: Zeolitic Imidazolate Framework-8 (ZIF-8) is a type of typical metal organic framework (MOF), which is an emerging porous coordination polymers that is bridged by zinc metal ions and organic linkages. Due to its intrinsic porous characteristics, unique pH sensitivity as well as superior drug loading efficiency, zeolitic imidazolate framework-8 has attracted extensive attention and received a wide range of applications in the field of biomedicine. In this review, we briefly discuss the effective delivery and controlled release of various drugs in ZIF-8, such as functional proteins, hydrophilic and hydrophobic drugs. Understanding the processes of various drugs loading is important for developing new drug delivery systems. In addition, we also explored the cooperation mechanism between ZIF and different materials. The combination of chemotherapy, photodynamic therapy, photothermal therapy and medical imaging have been applied in the field of nanomedicine and have made emarkable achievements.

 

Key words: zeolitic imidazolate framework-8, delivery and controlled release, multifunctional nano-platform

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