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Polysaccharides from Bletilla striata: Extraction, Optimization and Their Antioxidant Activities in vitro
Xiaojing Shena , Weiwei Jiang
Medicine Research    2020, 4 (3): 200010-.   DOI: 10.21127/yaoyimr20200010
Abstract240)      PDF (824KB)(401)       Save
In this paper, the extraction conditions of water-soluble polysaccharide from Bletilla striata were optimized by response surface methodology. With the dried Bletilla striata as raw materials, phenol-sulfuric acid method as the method of polysaccharide extraction rate, polysaccharide extraction rate as an indicator, the optimum process conditions for polysaccharide extraction from Bletilla striata were obtained including liquid-solid ratio of 15 mg/mL, extraction temperature 90 °C, extraction time of 90 h, sample immersion time 90 min, and extraction 2 times, achieving the corresponding polysaccharide yield of 48.38%. The antioxidant assays in vitro revealed that the polysaccharides from Bletilla striata exhibited a slight scavenging activity for 1,1-diphenyl-2- picrylhydrazyl radicals and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cations.
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Flavonoids, Phenylethanoids and Phenylpropanoids from Rhodiola rosea L. and Their Lipid-Lowering Activities on Receptor 5-HT 2A
Hao Wang, Ji-Lei Liang, Qing-Ming He, Guo-Hai Zhou, Cun-Fu Li, Ping-He Wei, and Hao-Yan Dong
Medicine Research    2020, 4 (4): 200018-200018.   DOI: 10.21127/yaoyimr20200018
Abstract244)      PDF (642KB)(337)       Save
Fifteen compounds, including 11 flavonoids, 2 phenylethanoids and 2 phenylpropanoids, were isolated from the roots of Rhodiola rosea L. Among them, quercetin ( 1) and quercetin-3- O-β-D-glucoside ( 2) were afforded from the genus Rhodiola for the first time. All isolates were evaluated for their agitating activities on receptor 5-HT 2A and four compounds ( 1215) showed obvious agitating activities, which were probably the main lipid-lowering active components of R. rosea L.
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An Update on Chemical Constituents from Nicotiana tabacum L. and Their Bioactivities from 2017 to 2020
Kuo Xu, Qian Liu, Lin Ni, Yong-Mei Du and Zhong-Feng Zhang
Medicine Research    2020, 4 (4): 200019-200019.   DOI: 10.21127/yaoyigc20200019
Abstract279)      PDF (911KB)(457)       Save
Nicotiana tabacum L., well known as tobacco, could be not only used for raw materials of producing cigarettes, but also as a folk Chinese herbal medicine. This paper offers a systematic review of newly reported compounds from N. tabacum over the past four years covering the literatures from the beginning of 2017 through the end of 2020 and describes their structural diversities and bioactivities. A total of 46 natural compounds and 42 references were updated and compiles in this review, which may be of interest to pharmacognosists and natural products chemists.
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Organic NIR Photodetectors: Pushing Photodiodes Beyond 1000 nm
Seth C. Rasmussen, Spencer J. Gilman, Evan W. Culver, and Wyatt D. Wilcox
General Chemistry    2021, 7 (2): 200019-200019.   DOI: 10.21127/yaoyigc20200039
Abstract649)      PDF (998KB)(677)       Save
Advances in the synthesis of low bandgap (E g < 1.5 eV) conjugated polymers has produced organic materials capable of absorbing near-infrared (NIR) light (800—2500 nm), with these materials first applied to photodiode NIR detectors in 2007 as an alternative to more traditional inorganic devices. Although the development of organic NIR photodetectors has continued to advance, their ability to effectively detect wavelengths in the low-energy portion of the NIR spectrum is still limited. Efforts to date concerning the production of photo-diode-based devices capable of detecting light beyond 1000 nm are reviewed.
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Phytochemical and Biological Progress of Ixeris sonchifoia (Bge.) Hance
Tingyu Wen, Fang Li, Jifeng Liu
Medicine Research    2019, 3 (1): 190002-.   DOI: 10.21127/yaoyimr20190002
Abstract156)      PDF (919KB)(296)       Save
Ixeris sonchifoia (Bge.) Hance is a famous traditional Chinese herb (TCH) for medicinal treatment and diet with wide distribution and rich resources. Flavonoids, triterpenoids and sesquiterpene lactones are the characteristic constituents of this TCH. Biological investigation on I. sonchifoia revealed the remarkable pharmacological activities of this herb for the treatment of cardiovascular and cerebrovascular diseases. This review summarized the phytochemical and biological progress of I. sonchifoia to provide a reference for further research and development of this TCH.
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New Songorine Derivatives as Novel G Protein-Coupled Receptor Antagonists: Syntheses and Preliminary Bioactivities Assay
Jiangming Wang, Ruihua Guo
Medicine Research    2019, 3 (1): 190003-.   DOI: 10.21127/yaoyimr20190003
Abstract214)      PDF (820KB)(360)       Save
In our early screening process, songorine isolated from Aconitum brachypodum diels possessed prominent activity of inhibiting class B G protein-coupled receptors (GPCRs). For further study, a series of ester and carbonyl derivatives were synthesized and their potential inhibitory activities on class B GPCRs were also assayed by the Double Antibody Sandwich ELISA (DAS-ELISA) in vitro. Moreover, the structure-activity relationships (SARs) of songorine derivatives were discussed in detail. In this paper, the story behind this study was described.
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Progress in Chemical Constituents and Bioactivities of Broussonetia pa-pyrifera (L.) Vent
Fang Li, Tingyu Wen, Jifeng Liu
Medicine Research    DOI: 10.21127/yaoyimr20190005
Online available: 18 June 2019

Progress of Picrotoxane Type Alkaloids in Dendrobium
Jingjuan Li, Fucai Ren, Jiangmiao Hu
Medicine Research    DOI: 10.21127/yaoyimr20190007
Online available: 22 July 2019

Plant-Derived Kavalactones and Their Bioactivities
Nenling Zhang, Linjing Wu, Xiang Liu, Xiangchun Shen
Medicine Research    2018, 2 (1): 170019-3.   DOI: 10.21127/yaoyimr20170019
Abstract376)   HTML102)    PDF (721KB)(793)       Save

Kavalactones, mainly found in Piper methysticum, are a class of lactone compounds usually with an arylethylene-pyrone skeleton. Till now, fifty-one kavalactones have been isolated from the genera Piper, Alpinia, Amomum, Polygala, Goniothalamus, and Dumortiera. The bioactivities of six kavalactones, kawain, 7,8-dihydro- kawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyagonin, have been studied extensively. This review aims to give an overview of kavalactones in the plants and their various bioactivities.

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Natural Products Phenols as Novel Antithrombotic Agents
Wenjing Zhou, Ruihua Guo
Medicine Research    2018, 2 (1): 180002-4.   DOI: 10.21127/yaoyimr20180002
Abstract315)   HTML51)    PDF (217KB)(522)       Save

Thrombosis owns the highest incidence, and it is a serious threat to human health. Currently, the clinical antithrombotic drugs suffer from several drawbacks, causing allergic reactions or complications, etc. In recent years, small-molecule compounds isolated from natural products with antithrombotic activities in the field drug research on thrombus disease. In this review, we will focus on representative naturally occurring small molecule phenols with antithrombotic potency and potential for future therapeutic regimens to combat thrombosis disease.

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Recent Advances on anti-MRSA Natural Products Derived from Plants
Jing Guo, Xiaoyu Su, Tianfang Ma, Jifeng Liu
Medicine Research    2018, 2 (1): 170018-5.   DOI: 10.21127/yaoyimr20170018
Abstract492)   HTML80)    PDF (702KB)(658)       Save

Methicillin-resistant Staphylococcus aureus (MRSA) is a multi-drug resistant pathogenic bacteria, which has seriously threatened human health for a long time. Therefore, there is an urgent and unmet demand for new types of antibiotics. In response to the antibiotic resistance, many researchers have studied natural products derived from plant for alternative antibiotics and therapies. In this review, we summarized recent advances on anti-MRSA natural products from plants and their potential antibacterial effect against MRSA as potential anti-MRSA agents since 2007.

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Progress in Chemical Constituents and Pharmacological Effects of Lindera glauca
Jianchen Liu, Chunyan Du, Yanan Li, Shiman Zuo, Rui Tan, Hezhong Jiang
Medicine Research    2018, 2 (1): 180003-3.   DOI: 10.21127/yaoyimr20180003
Abstract366)   HTML60)    PDF (436KB)(451)       Save

Lindera glauca is a folk medicine with rich resources in China. Previous phytochemical studies on L. glauca have resulted in the isolation and identification of the main chemical constituents such as alkaloids, sitosterol, flavonoids, sesquiterpenes, and lignans, as well as essential oil, with antimicrobial, antitumor activity and other pharmacological effects. In this paper, the chemical compositions and pharmacological effects of L. glauca were summaried.

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Phytochemical Compositions and Bioactivities of Juglans regia Shell and Green Husks
Wenjing Zhou, Zhai Shiyang, Ruihua Guo
Medicine Research    2018, 2 (2): 180007-.   DOI: 10.21127/yaoyimr20180007
Abstract346)   HTML52)    PDF (1096KB)(353)       Save

The walnut kernel has appeared on dining tables as a non-staple food and gained much popularity for centuries owing to its flavor as well as the function of food therapy, while the green husk or hard shells enwrapped are always discarded or processed into low value-added products. The waste of walnut green husk and shell can cause environment pollution and the waste of resources. As medicinal food, lots of researches on walnut have been carried out during the past decades, including the walnut kernel, the green husk and the hard shell. The researches on the green husk and hard shell showed the mass of chemical compounds isolated from both green husk and hard shell possesses various bioactivities such as antimicrobial, antioxidant, antitumor, and other effects. In this paper, we summarized phytochemical compositions of green husk and hard shell of walnut (Junglans regia) as well as their bioactivities.

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Phytochemical and Biological Progress of Cynanchum paniculatum
Liangyan Liu, Chang-An Geng
Medicine Research    2019, 3 (1): 190200-.   DOI: 10.21127/yaoyimr20190200
Abstract179)      PDF (881KB)(365)       Save
Cynanchum paniculatum (Xuchangqing) is a famous traditional Chinese herb (TCH) widely used for treating rheumatism and pains in China. C 21 steroids and acetophenones are the characteristic constituents in this TCH, from which a total of 61 compounds have been reported involving 32 C 21 steroids, 13 phenols, seven triterpenoids and nine other compounds. Biological investigation on this herb revealed the anti-inflammatory, anti-snake venom, anti-microbial, neuroprotective and anti-cancer properties of the pure compounds or crude extracts. This minireview summarized the phytochemical and biological progress of C. paniculatum to provide a reference for better understanding the effective substances of Xuchangqing.
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Stilbenoids from Leguminosae and their Bioactivities
Xinyu Lei, Qinru Zhou, Wenju Li, Guifang Qin, Xiangchun Shen, Nenling Zhang
Medicine Research    2019, 3 (4): 200004-.   DOI: 10.21127/yaoyimr20200004
Abstract270)      PDF (2258KB)(730)       Save
Stilbenoids, usually found in Leguminosae, are a class of compounds with the skeleton of stilbene or their polymers, existing mostly in the xylem of plants. Till now, one hundred and seventy-six stilbenoids have been isolated from plants of Leguminosae. Herein, stilbene compounds and their derivatives in Leguminosae and their biological activities including anti-neoplastic, anti-bacterial, anti-inflammation are reviewed.
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Progress in Chemical Constituents and Pharmacological Effects of Citrus medica L. var. sarcodactylis Swingle
Shuyu Xu, Yin Qu, Xinyu Liu, Yao Li, Jimin Liu, Hezhong Jiang
Medicine Research    2020, 4 (1-2): 190014-190014.   DOI: 10.21127/yaoyimr20190014
Abstract321)      PDF (580KB)(424)       Save
Citrus medica L. var. sarcodactylis Swingle is known as Foshou fruit that can be used as Chinese medicinal materials and has a health and longevity effect. In recent years, investigations about the chemical compounds of Citrus medica L. var. sarcodactylis Swingle have shown that its main compounds include flavonoids, essential oils, coumarins, and polysaccharides, with anti-inflammatory, antimicrobial, antioxidant activity, effect on the autonomic nervous system, and other pharmacological effects. In this paper, the chemical compositions and pharmacological effects of Citrus medica L. var. sarcodactylis Swingle are summarized.
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Diterpenoids from the genus Illicium and Their Bioactivities
Yingying Fu, Junyan Chu, and Jifeng Liu
Medicine Research    2020, 4 (1-2): 200005-200005.   DOI: 10.21127/yaoyimr20200005
Abstract250)      PDF (540KB)(375)       Save
Diterpenoids are important chemical constituents isolated from the genus Illicium, which possess many pharmacological effects such as anti-inflammatory, antiviral activities, cytotoxicity, and so on. Up to now, 68 diterpenoids have been isolated from the genus Illicium, and they are classified as abietane-type, pimarane-type and podocarpane-type. In this paper, the chemical constituents and bioactivities of the diterpenoids from the genus Illicium are reviewed.
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Progress in Chemical Compositions and Pharmacological Activities of FlosPopuli
Junyan Chu, Yingying Fu, and Jifeng Liu
Medicine Research    2020, 4 (1-2): 200006-200006.   DOI: 10.21127/yaoyimr20200006
Abstract179)      PDF (790KB)(328)       Save
FlosPopuli is a dry male inflorescence of Populus tomentosa., Populus canadensis. Some researches show that FlosPopuli contains rich flavonoids and phenolic glycosides, which have antibacterial, anti-inflammatory, anti-oxidant and anti-viral effects. In order to systematically understand the chemical compositions and biological activities of FlosPopuli and lay the foundation for subsequent research, this article reviews the two above aspects. Fifty-three kinds of flavonoids, phenol glycosides and others were isolated from FlosPopuli; moreover, their antibacterial, anti-inflammatory and hypolipidemic effects were investigated.
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Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis
Tao-Tao Xue, Hong-Bo Xu, Zhi-Shu Tang, Jin-Ao Duana, Hong-Bo Liu, Xin-Bo Shi, and Zhong-Xing Song
Medicine Research    2021, 5 (2): 210002-210002.   DOI: 10.21127/yaoyimr20210002
Abstract602)      PDF (717KB)(1000)       Save
Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.
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Progress in Phytochemical and Bioactivities of Coffea arabica L.
Xiao-Jing Shen, Zhu-Bin Zhou, Fan-Qiu Nie, Cheng-Ting Zi, and Jiang-Ping Fan
Medicine Research    2020, 4 (3): 200012-.   DOI: 10.21127/yaoyimr20200012
Abstract553)      PDF (1601KB)(747)       Save
Coffea arabica L. is a famous specie in genus caffee for medicinal treatment and diet with wide distribution and rich resources. It contains rich alkaloids, flavonoids and terpenes, which exhibited antioxidation, anti-inflammatory, antitumor, antidiabetic, live protection, and neuroprotective activities. Herein, we summarized the progress in the chemical constituents and bioactivities of C. arabica L. to provide ideas for medicinal development prospects of C. arabica L.
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Natural Products from the genus Daldinia and Their Bioactivities

Jing Li, Luohao Li, Runqing Zhu, Vuanghao Lim, Qianqian Sun, and Lizhen Fang
Medicine Research    2021, 5 (3-4): 210005-210005.   DOI: 10.21127/yaoyimr20210005
Abstract254)      PDF (1005KB)(471)       Save
Genus Daldinia is a unique source of natural products, which possess many pharmacological effects such as antibacterial activity, cytotoxicity, antioxidant activity, α-glucosidase inhibitory activity, and so on. Recently, most studies of genus Daldinia were focused on D.eschscholzii, D.concentrica and D.sp. This paper covers nearly a decade of research on Daldinia, focusing on the chemical structures and related biological activities of the secondary metabolites produced.
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