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Cover Illustration
2020, Vol.4  No.3
The cover picture shows EGFR signal transduction: when the extracellular domain binds to growth factors or other ligands, EGFR dimerization with other members of the family results in phosphorylation of tyrosine kinase and activating various signaling pathways downstream of EGFR, such as MAPK, PI3K/Akt and STAT, leading to gene transcription, cell cycle progression and apoptosis. In addition, the advances of small-molecule inhibitors on the target of EGFR include 4-anilinoquinazolines, “U-type” pyrimidines, thiophene [3,2-d] pyrimidines, oxyisoindoles and amino benzimidazoles. More details are discussed in the article by Zi et al. on page 200011.

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  • Table of Content
      Sept. 2020, Volume 4 Issue 3 Previous Issue    Next Issue
    For Selected: View Abstracts Toggle Thumbnails
    Contents
    Contents: Med. Res. 3/2020
    Medicine Research
    Medicine Research. 2020, 4 (3): 209003.  
    Abstract   PDF (299KB) ( 5 )
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    Hotspots
    Hydroxychloroquine for the Treatment of Coronavirus Disease 2019: Evidence, Possible Mode of Action and Industrial Supply
    Mario Pagliaro, Francesco Meneguzzo
    Medicine Research. 2020, 4 (3): 200014.   DOI: 10.21127/yaoyimr20200014
    Abstract   PDF (678KB) ( 136 )
    Hydroxychloroquine, a known antiviral metabolite of chloroquine, is increasingly used along with antibiotic azithromycin for the treatment of COVID-19 infection. In about one month, India, the world’s largest manufacturer, delivered the pharmaceutical ingredient for treating COVID-19 to over 50 countries. Coupled to azithromycin, the therapy is being used across the world both for patients staying at home at the early phase of symptoms, as well as for patients hospitalized. We summarize achievements as of late April 2020, review possible modes of action and suggest avenues for the quick scale-up of production of hydroxychloroquine.
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    Minireviews
    Recent Advances on Small-Molecule Epidermal Growth Factor Receptor Inhibitors
    Bo-Ya Shi, Ze-Hao Wang, Xuan-Jun Wang Jun Sheng, and Cheng-Ting Zi
    Medicine Research. 2020, 4 (3): 200011.   DOI: 10.21127/yaoyimr20200011
    Abstract   PDF (418KB) ( 59 )
    The epidermal growth factor receptor (EGFR) is a kind of cell membrane surface receptor with tyrosine kinase activity, which is closely related to the growth, proliferation, differentiation, apoptosis, metastasis and other processes of tumor cells. Targeting EGFR tyrosine kinase inhibitors has become a hot topic for drug development for treatment of non-small-cell cancer (NSCLC). Herein, we summarized recent advances on the targeted therapeutic drugs for NSCLC in recent years.
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    Progress in Phytochemical and Bioactivities of Coffea arabica L.
    Xiao-Jing Shen, Zhu-Bin Zhou, Fan-Qiu Nie, Cheng-Ting Zi, and Jiang-Ping Fan
    Medicine Research. 2020, 4 (3): 200012.   DOI: 10.21127/yaoyimr20200012
    Abstract   PDF (1601KB) ( 109 )
    Coffea arabica L. is a famous specie in genus caffee for medicinal treatment and diet with wide distribution and rich resources. It contains rich alkaloids, flavonoids and terpenes, which exhibited antioxidation, anti-inflammatory, antitumor, antidiabetic, live protection, and neuroprotective activities. Herein, we summarized the progress in the chemical constituents and bioactivities of C. arabica L. to provide ideas for medicinal development prospects of C. arabica L.
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    Progress in Percutaneous Penetration Enhancers from Traditional Chinese Medicines
    Yingying Huang, Jinyu Yi, Chaoyan Zhang
    Medicine Research. 2020, 4 (3): 200008.   DOI: 10.21127/yaoyimr20200008
    Abstract   PDF (614KB) ( 115 )
    Percutaneous penetration enhancers can regulate the transdermal absorption of drugs. Generally speaking, it can be divided into two categories: chemical synthesis and natural sources. Natural percutaneous penetration enhancers have the advantages of safety and mildness. This review summarizes the mechanism and characteristics of three kinds of percutaneous penetration enhancers and their combined application in transdermal drug delivery systems. The three different types of percutaneous penetration enhancers are fatty acids, alkaloids and terpenes. It is expected to provide considerations for the application research of percutaneous penetration enhancers rich in traditional Chinese medicines in transdermal drug delivery systems.
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    Reports
    Polysaccharides from Bletilla striata: Extraction, Optimization and Their Antioxidant Activities in vitro
    Xiaojing Shena , Weiwei Jiang
    Medicine Research. 2020, 4 (3): 200010.   DOI: 10.21127/yaoyimr20200010
    Abstract   PDF (824KB) ( 62 )
    In this paper, the extraction conditions of water-soluble polysaccharide from Bletilla striata were optimized by response surface methodology. With the dried Bletilla striata as raw materials, phenol-sulfuric acid method as the method of polysaccharide extraction rate, polysaccharide extraction rate as an indicator, the optimum process conditions for polysaccharide extraction from Bletilla striata were obtained including liquid-solid ratio of 15 mg/mL, extraction temperature 90 °C, extraction time of 90 h, sample immersion time 90 min, and extraction 2 times, achieving the corresponding polysaccharide yield of 48.38%. The antioxidant assays in vitro revealed that the polysaccharides from Bletilla striata exhibited a slight scavenging activity for 1,1-diphenyl-2- picrylhydrazyl radicals and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cations.
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