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Medicine Research    2017, Vol. 1 Issue (2) : 35     DOI: 10.21127/yaoyimr20170010
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Activities of Naturally Occurring Alkaloids Bulleyaconitine A
Shiyang Zhaia†,Wenjing Zhoua†,Yifan Xua,Xiaosu Wanga,Xiao Yea,Shuyue Wanga,Wenhui Wua,Ruihua Guoabcde*
a College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
b Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China
c National Experimental Teaching Demonstration Center for Food Science and Engineering (Shanghai Ocean University), Shanghai 201306, China
d Laboratory of Quality and Safety Risk Assessment for Aquatic Product on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China
e Quality Supervision, Inspection and Testing Center for Cold Storage and Refrigeration Equipment, Ministry of Agriculture, Shanghai 201306, China
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Abstract  

Bulleyaconitine A, a C19-diterpenoid alkaloid extracted from Aconitum bulleyanum Diels, showed various bioactivities, including anti-inflammatory, antinociceptivity, immunomodulatory effects as well as some toxicities. This paper reviewed the bioactivities of Bulleyaconitine A and the relevant mechanisms, toxicities, as well as the metabolism.
Keywords bulleyaconitine A      antinociceptivity      anti-inflammatory      immunomodulatory effects      toxicities     
Corresponding Authors: Shiyang Zhai,Wenjing Zhou,Ruihua Guo   
Issue Date: 07 December 2017
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Shiyang Zhai
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Cite this article:   
Shiyang Zhai,Wenjing Zhou,Yifan Xu, et al. Activities of Naturally Occurring Alkaloids Bulleyaconitine A[J]. Medicine Research, 2017, 1(2): 3537.
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http://www.medicineresearch.org/EN/10.21127/yaoyimr20170010    
Figure 1  The structure of bulleyaconitine A.
Figure 2  The structures metabolites of bulleyaconitine A.
Metabolites R R1 R2 R4 R5 R6 R7 R8 Enzymes
M1 -C2H5 -OMe -H -C2H5O -OAc -H -OH -OMe CYP3A, 2C, 2D, 2E1
M2 -C2H5 -OH -H -C2H5O -OAc -H -OH -OMe Transformed by M1 or M3
M3 -C2H5 -OH -H -C2H5O -OAc -H -OMe -OMe CYP3A, 2C, 2E1
M4 -C2H5 -OMe -H -C2H5O -OH -H -OMe -OMe CYP3A, 2C, 2D, 2E1
M5 -C2H5 -OMe -H -H -OAc -H -OMe -OMe CYP3A, 2C
M6 -C2H5 -OMe Δ2,3 -C2H5O -OAc -H -OMe -OMe CYP3A, 2C
M7 -C2H5 -OMe -OH -C2H5O -OAc -H -OMe -OMe CYP3A, 2C, 2D
M8 -C2H5 -OMe -H -C2H5O -OAc Δ15,16 Δ15,16 -OMe CYP3A, 2C
M9 -C2H5 -OMe -H -C2H5O -OAc -OH -OMe -OMe CYP3A, 2C, 2D
M10 -C2H5 -OMe -H -C2H5O -OAc -H -OMe - CYP3A,2C
M11 -C2H5 -OMe -H -C2H5O -OAc -H -OMe -OMe CYP3A, 2C, 1A2, 2E1
M12 - -OMe -H -C2H5O Δ8,15 Δ8,15 -OMe -OMe CYP3A, 2C, 2D, 2E1
Table 1  The structures metabolites of bulleyaconitine A
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