Medicine Research

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1. The Effect and Underlying Mechanism of Sleep Deprivation on Several Gastrointestinal Physiology and Diseases

Yi-Fan Li, Lu-Yu Niu, Jie-Fu Fan, Zhi-Chao Yao, Ling-Yun Shen, Yang-Kai Wang, Ying He

Medicine Research 2024, 8 (1): 230006-230006. DOI: 10.21127/yaoyimr20230006

摘要（82）

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The incidence of sleep deprivation has increased significantly in contemporary society. Gastrointestinal diseases, one of the diseases with high incidence caused by sleep deprivation, are increasingly becoming a serious public health threat worldwide. However, confusion about underlying mechanism by which sleep deprivation exacerbates gastrointestinal dysfunction has always hindered people from carrying out effective clinical treatment. In this paper, we review the effects of sleep deprivation on four gastrointestinal physiology and further reveal the mechanism by which sleep deprivation exacerbates several gastrointestinal diseases, providing a new perspective for people to better understand and treat related diseases.

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2. Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System in Vitro

Xinyi Pu, Boyu Chen, Xiaozhen Diao, Hui Han, Jinhua Hou, Jiudong Hu, Yuhuan Yang, Yuping Zhu, Wenhui Wu

Medicine Research 2023, 7 (3-4): 230011-230011. DOI: 10.21127/yaoyimr20230011

摘要（91）

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Glucokinase (GK), as a key enzyme regulating carbohydrate metabolism, has been widely researched as a therapeutic target for diabetes. This study aimed to investigate the influence of magnesium ion concentration, ATP concentration, and enzyme concentration on the catalytic activity of GK by response surface. A cellular model of insulin resistance (IR) was established to observe the ameliorating effect of magnesium ion on IR by screening the concentration and duration of insulin action. The results indicated that the optimal concentrations for enzyme activity were found to be 1.1 mM for magnesium ion, 1.4 mM for ATP, and 0.5 U/mL for glucokinase. In the presence of taurine, the IR model was treated with magnesium ion (1.1 mM) can promote glucose consumption, GK activity and intracellular magnesium concentration in IR cells. Magnesium ion, as a key factor in GK-catalyzed glycolysis, showed a positive correlation between intracellular magnesium ions and the catalytic activity of GK within a certain concentration range. Therefore, magnesium ion could effectively promote carbohydrate metabolism and alleviate the progression of IR.

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3. Progress in Antidiabetic Effects of Sesquiterpenoids

Kunyi Zhang, Yi Liu, Feixiang Guo, Huiqin Zheng, Qianqian Sun, Lizhen Fang

Medicine Research 2023, 7 (3-4): 230009-230009. DOI: 10.21127/yaoyimr20230009

摘要（93）

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Sesquiterpenoids have a wide range of physiological activities, and have potent effects against various diseases. In recent years, many sesquiterpenoids have been reported to show significant bioactivities on diabetes mellitus that is an increasingly severe metabolic disease. In this paper, the bioactivities of sesquiterpenoids on diabetes mellitus in the past twenty years are reviewed.

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4. Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems

Zhao Wang, Jingjing Sun, Ruilong Sheng

Medicine Research 2023, 7 (3-4): 230008-230008. DOI: 10.21127/yaoyimr20230008

摘要（125）

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In the past decades, many polyethylene glycol (PEG)-containing polymers were developed and widely utilized to prepare functionalized nano delivery systems with hydrophilic shielding feature and high body fluid/environmental stability. Notably, some surface physicochemical properties of the PEG-containing polymers largely determined their solution properties and interactions with other biomolecules, which thus subsequently influenced their biological behaviors. In this paper, we summarized recent advances on the surface physicochemical properties of PEG-containing polymer nano systems and their impacts on self-assembly, solution stability, biomolecular interactions, as well as drug delivery. Future research outlooks in this area were also stated and discussed.

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5. 2,4-Dinitrophenylhydrazine Pre-column Derivatization: High Performance Liquid Chromatography Determination of Residual Formaldehyde in Pharmaceutical Industry and Key Parameters Analysis

Guoyin Yin, Ruilong Sheng

Medicine Research 2024, 8 (1): 240001-240001. DOI: 10.21127/yaoyimr20240001

摘要（61）

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Formaldehyde is a colorless gas with a pungent odor, and it is commonly used in many industries to produce resins, plastics, textiles, household products, as well as pharmaceutics. Accurate formaldehyde analysis is significant for environmental and industrial control. In this paper, formaldehyde is analyzed as its 2,4-dinitrophenylhydrazine derivative through a high performance liquid chromatography method. The method has been validated for specificity, limit of detection, limit of quantification, linearity and range, precision, accuracy, and solution stability, which showed simplicity, speed, and accuracy, making it well-suited for the determination of traceable levels of formaldehyde in the pharmaceutical industry.

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6. Progress in Anti-Inflammatory Effect of Ellagic Acid

Meiyan Duan, Zemin Xiang, Huanhuan Xu

Medicine Research 2024, 8 (1): 240002-240002. DOI: 10.21127/yaoyimr20240002

摘要（85）

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Inflammation is an adaptive physiological state caused by tissue injury, stress or infection that restores tissue homeostasis. Recent studies have shown that inflammation is a major factor in the progression of various diseases, including arthritis, inflammatory bowel disease, asthma and cancer. Currently, the treatment of inflammatory diseases mainly consists of steroids and non-steroidal anti-inflammatory drugs. However, long term use can lead to serious adverse reactions. In recent years, ellagic acid has received much attention due to its safety and anti-inflammatory activities. In this paper, we review research progress in anti-inflammatory effects of ellagic acid hoping to further understand its effectiveness and provide the guidance for development and application of clinical anti-inflammatory drugs.

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7. A Novel Combined Nanoparticle Delivery of Poly(ADP-Ribose) Polymerase Inhibitor-Olaparib and Copper Complexes for Chemosensitization Therapy in Breast Cancer

Xiaoya Huang, Kehai Liu

Medicine Research 2023, 7 (3-4): 230007-230007. DOI: 10.21127/yaoyimr20230007

摘要（101）

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Chemo-sensitization therapy has gained importance in the field of anti-cancer treatment in recent years. The combination of both chemotherapy and chemosensitization has unique advantages. However, there has been relatively limited research on combination treatment using metal complexes and chemosensitizers. Herein, we reports a two-drug synergistic delivery system combining a copper complex and a chemosensitizer Olaparib in a certain ratio of safety and efficiency is the key. Polyethylenimine (PEI) was chemically-linked to activated chemosensitizer Olaparib, which was connected to a bifunctional peptide, T15, for facilitation and nuclear targeting, resulting in Ola-PEI-T15. Then, a novel metal complex Cu/Ola-PEI-T15 was obtained by Cu ²⁺ coordination to Ola-PEI-T15. The two therapeutic agents can be transported into the cells at the same time, giving full play to the synergistic anti-tumor effect.

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8. Effects of Different Packaging Methods on Freshness of Larimichthys polyactis during Cold Storage

Zibin Ma, Ruihua Guo, Bin Bao, Wenhui Wu

Medicine Research 2024, 8 (1): 240004-240004. DOI: 10.21127/yaoyimr20240004

摘要（76）

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Taking Larimichthys polyactis, a rare seafood from Zhejiang Province, as the research object, sensory evaluation, pH, microbial analysis, texture, water retention, K value, total volatile basic nitrogen (TVB-N value), TCA-soluble peptide, thiobarbiturate acid value, the effects of ordinary packaging, vacuum packaging and air-conditioned packaging on the quality of Larimichthys polyactis during the refrigeration process were studied. The results showed that the sensory comprehensive score, texture and water retention of Larimichthys polyactis were gradually decreased with the extension of refrigeration time. The TVB-N value and TBA value of Larimichthys polyactis under the three different packaging treatments increased with the extension of time, and the change of K value was consistent with the TVB-N value. The TVB-N value, TBA value and K value of Larimichthys polyactis in air-conditioned packaging group increased slowly. The content of TCA-soluble peptide indicated that both vacuum and air-conditioned packages had a good effect on inhibiting protein degradation. According to the evaluation indexes, the air conditioning package is beneficial to keep the freshness of Larimichthys polyactis under the cold storage condition.

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9. A Perspective of 6,12-Guaianolides and Their Analogues: Synthesis, Bioactivity and Structure-Activity Relationships

Ruihua Guo, Guo Y. Yin, Ruilong Sheng

Medicine Research 2024, 8 (1): 230010-230010. DOI: 10.21127/yaoyimr20230010

摘要（68）

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Recently, the study on 6,12-guaianolides, a family of natural guaiane-type sesquiterpenoids, has attracted increased attention in the field of chemical synthesis, pharmaceutics, and medicinal chemistry. Many 6,12-guaianolide compounds and their analogues showed remarkable molecular diversity, structural modifiability, and versatile biological and pharmacological properties, such as anticancer, antivirus, anti-inflammatory, endogenous NO production inhibition, and so on. In this paper, we summarized recent advances on the synthesis methods of 6,12-guaianolides and their analogues, briefly described their bioactivities, and elucidated the quantitative structure-activity relationship of some 6,12-guaianolides and their analogues. Furthermore, the perspectives of 6,12-guaianolides and their analogues were discussed.

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10. Contents: Med. Res. 3-4/2023

Medicine Research 2023, 7 (3-4): 0-0.

摘要（54）

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