Medicine Research

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1. Study on Chemical Constituents and Bioactivities from Eucalyptus globulus

Shudan Zheng, Hui Fang, Jifeng Liu

Medicine Research 2021, 5 (3-4): 210007-210007. DOI: 10.21127/yaoyimr20210007

摘要（234）

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Eucalyptus globulus ( E. globulus) is a tall timber tree of genus Eucalyptus (Myrtaceae), and it is mainly distributed in the southern and southwestern China. The dry fruits of E. globulus, called as ‘Yi-Kou-Zhong’ in Chinese, have been commonly used as a traditional Chinese medicine to treat in flammation, eczema, and influenza. Herein, we summarized the chemical constituents and bioactivities of the Eucalyptus globulus.

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2.

Natural Products from the genus Daldinia and Their Bioactivities

Jing Li, Luohao Li, Runqing Zhu, Vuanghao Lim, Qianqian Sun, and Lizhen Fang

Medicine Research 2021, 5 (3-4): 210005-210005. DOI: 10.21127/yaoyimr20210005

摘要（280）

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Genus Daldinia is a unique source of natural products, which possess many pharmacological effects such as antibacterial activity, cytotoxicity, antioxidant activity, α-glucosidase inhibitory activity, and so on. Recently, most studies of genus Daldinia were focused on D.eschscholzii, D.concentrica and D.sp. This paper covers nearly a decade of research on Daldinia, focusing on the chemical structures and related biological activities of the secondary metabolites produced.

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3.

Progress in Chemical Constituents and Bioactivities of Perilla frutescens (L.) Britt

Hui Fang, Shudan Zheng, Jifeng Liu

Medicine Research 2021, 5 (3-4): 210008-210008. DOI: 10.21127/yaoyimr20210008

摘要（344）

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Perilla frutescens (L.) Britt is an annual herb of the genus Perilla in the labiaceae. Its leaves, stalks and fruits can be used as folk medicine. The chemical components in Perilla frutescens (L.) Britt can be divided into volatile oil, terpenoids, triterpenoids, steroids, glycosides, phenylpropanoids and phenolic acids, flavonoids and pigments, which have anti-allergy, antibacterial, hypolipidemia, antioxidation, antitumor, antitussive and antipyretic activities. In this paper, we reviewed research progress of chemical constituents and pharmacological effects of Perilla frutescens to provide new ideas for subsequent development of Perilla frutescens (L.) Britt.

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4.

Progress in Terpenes from Genus Paeonia

Lei Sun, Chuihao Kong, Huan Zhao, Deling Wu, Fengqing Xu

Medicine Research 2021, 5 (3-4): 210011-210011. DOI: 10.21127/yaoyimr20210011

摘要（208）

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Paeonia is the single genus of ca. 35 known species in the family Paeoniaceae. Up to now, more than 185 terpenes have been isolated from root/root cortex, flowers and seeds of the genus Paeonia. Researches had focused on the following species, such as P. lactiflora, P. suffruticosa Andr, P. veitchii, P. labiflora, P. delavayi, P. rockii, P. emodi, P. peregrina, and P. japonica. In this paper, the terpenes of Paeonia were reviewed, which may provide more useful information for further development on this genus.

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5. Progress in Skin Care Efficacy of Lactoferrin

Tong Xie, Wu Qiao, Tinghan Jia, and Ken Kaku

Medicine Research 2022, 6 (1-2): 210015-210015. DOI: 10.21127/yaoyimr20210015

摘要（354）

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Lactoferrin is an iron-binding glycoprotein with a variety of biological activities, including anti-inflammatory, antibacterial, antitumor, antiviral, whitening, repairing skin damage caused by inflammation, immune regulation, and osteogenic activity. As a protein with great development potential, lactoferrin is widely used in the fields of food, medicine and cosmetics. The effect of lactoferrin on the skin is particularly prominent, and it has the potential to be used as a new raw material for skin care products. Researchers have reviewed biological activities of lactoferrin and its microbial mechanism of action. Therefore, this article focuses on the skin care efficacy of lactoferrin. This article reviews the latest research results of lactoferrin in skin care efficacy.

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6. Progress in Phytochemical and Bioactivities of Areca catechu L

Zhenshuai Tang, Jifeng Liu

Medicine Research 2022, 6 (3-4): 220004-220004. DOI: 10.21127/yaoyimr20220004

摘要（251）

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Areca catechu L is a genus of plants whose leaves and fruits can be used as folk medicine. The chemical composition of A. catechu can be divided into alkaloids, flavonoids, tannins, terpenoids, sterols, fatty acids, etc. It has pharmacological effects such as anti-inflammatory, antioxidant, antibacterial, antidepressant, hypotensive, etc., while having toxic side effects such as oral toxicity, hepatotoxicity and addiction. This paper reviews the progress of research on chemical composition and pharmacological effects and toxic side effects of A. catechu, and provides new ideas for subsequent development of A. catechu.

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7. Pharmacist Intervention with Computer-Based Alert System and Assessment of Prescription Errors for Outpatient in a Chinese Tertiary Hospital

Qing Shen, Yi-Meng Zhou, Jin Lv, Hua Yang, Yuan-yuan He, Yuan Bian, Yong Han

Medicine Research 2021, 5 (3-4): 210009-210009. DOI: 10.21127/yaoyimr20210009

摘要（147）

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Qualified prescribing is fundamental for appropriate use of medicine. Pharmacist interventions potentially remind physicians to cope with this issue. This study aimed to report interventions implemented by pharmacists with real-time computer-based alert system and evaluate the prescription errors for outpatients in a Chinese tertiary hospital. This retrospective, non-comparative study was implemented with an analysis of data collected from October to December in 2018 involved all clinical specialty departments in the hospital. Alerts were generated and displayed on pharmacist screen while prescribing inappropriately, then pharmacists chose certain operation and offered recommendations according to the alerts. Outcomes such as category and acceptance rate of pharmacist recommendations, prescription error types, prevalence rate, severity level and monthly tendency were documented, categorized and analyzed. In our study, 2.3% of prescriptions generated alerts, and incidence of pharmacist interventions was 0.19%. 431 prescription errors were prevented, with the overall acceptance rate of interventions accounted for 29.7%. Dosage or frequency problems ( n = 170, 39.5%), contraindications ( n = 79, 18.3%) and improper duration of pharmacotherapy ( n = 53, 12.3%) were the top three types of prescription errors. Monthly rate of errors decreased from 0.98 to 0.43 per 1000 prescriptions in the monitoring period. Pharmacist interventions with computer-based alert system were available for filtering part of invalid alerts and preventing prescription errors in our study.

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8. Progress in Chemical Constituents and Pharmacological Effects of Lindera obtusiloba Bl

Hong Zhou, Qingtian Gao, Jisong Mo, Jimin Liu, Na Pan, Chunyi Duan, Xin Chen, Hezhong Jiang

Medicine Research 2021, 5 (3-4): 210010-210010. DOI: 10.21127/yaoyimr20210010

摘要（177）

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Lindera obtusiloba Bl belongs to the genus Lindera, which has a long history of medicinal use and a wide range of uses. It has many significant physiological activities such as improving blood circulation, treating inflammation and preventing liver injury. Investigations about the chemical compounds of L. obtusiloba have shown that its main compounds include butyrolactones, lignans, flavonoids, phytosterols, volatile oils and phenolic glycosides, with antibacterial, anti-inflammatory, cytotoxicity, anti-oxidation and anti-fibrosis activities. At present, there are few reports on its chemical constituents and physiological activities. Herein, we summarized the reported chemical constituents and physiological activities of L. obtusiloba and laid a foundation for further research.

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9. Chemical Research on Limonoids Isolated from the Fruits of Melia toosendan

Hao Wang, Hao-Yan Dong, Yan-Fang Liu, Yu-Xiang Ma, Wei Wang, Zhi-Mou Guo and Chao-Ran Wang

Medicine Research 2022, 6 (1-2): 210014-210014. DOI: 10.21127/yaoyimr20210014

摘要（152）

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As the characteristic components from the fruits of Melia toosendan, limonoids attract continuous research interest for their chemistry and biodiversity, and their analogues are continuously obtained from this plant. Thus, limonoids isolated from the fruits of M. toosendan were investigated, classified and the biogenic metabolic pathway were supposed to provide more information for further research on the title plant.

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10. Preparation of Ti Doped Nano-ZnO Dispersion and Their Application in Deodorization and Antibiosis

Lin Lin, Shuhong Wu, Xiaoyan Wu, Zheng Zhu, Yongxin Wu, Jun Zhu

Medicine Research 2022, 6 (3-4): 220003-220003. DOI: 10.21127/yaoyimr20220003

摘要（167）

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To develop an effective deodorant and antibacterial agent, we prepare a Ti doped nano-ZnO through a low temperature hydrothermal route. The shape and size of these as-prepared samples can be tuned effectively by controlling the reaction conditions, such as the molar ratio of Ti/Zn. Furthermore, the sample with an appropriate portion of Ti and Zn is selected to obtain dispersion for improving sample activity and avoiding sample agglomeration. XRD, SEM, EDX and DLS are performed to characterize the structure and morphology of samples. Furthermore, the typical dispersion is used to remove odorous molecules and kill bacteria. The results show that polycarboxylic acid can be used to improve the dispersibility and stability of nanoparticles, and the well-dispersed dispersion is high effective for deodorization and antibiosis. Moreover, CCK-8 assays are performed to evaluate the cytotoxicity of dispersions with different size. The result reveals that dispersion with a smaller particle size displayed more serious toxicity. Thus, we suggest that the obtained dispersion can be used as a deodorant and antibacterial agent, but it is necessary to take precautions when handling the dispersion because the nanoparticles, special smaller nanoparticles is more likely to cause serious cytotoxicity.

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11. Recent Advances on Anticancer Effects and Molecular Mechanisms of Maslinic Acid

Jin Li, Xiaomei Yang, Wei Jiang, Qianqian Hu, Xuanjun Wang, Huanhuan Xu

Medicine Research 2022, 6 (3-4): 220002-220002. DOI: 10.21127/yaoyimr20220002

摘要（219）

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Cancer has become a serious public health concern that affects millions of individuals annually in the world. Surgical resection, chemotherapy and radiotherapy have been considered as the standard treatment strategies for different kinds of cancers. Among them, chemotherapeutic agents are usually used for the treatment of malignancies but toxic side effects and drug resistance limit their clinical efficacy. Natural compounds isolated from medicinal plants are excellent and reliable sources of new anticancer drugs. Maslinic acid is a naturally occurred pentacyclic triterpenoid with anticancer activities. This review mainly focuses on recent advances on anticancer effects and molecular mechanisms of maslinic acid and will hopefully provide valuable insights into clinical application of maslinic acid to the treatment of cancers.

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12. Recent Advances on Drug Treatments of Rheumatoid Arthritis

Chunxia Gan, Mingzhen Yu, Ergu Chen, Xuanjun Wang, Huanhuan Xu

Medicine Research 2022, 6 (1-2): 210012-210012. DOI: 10.21127/yaoyimr20210012

摘要（211）

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Rheumatoid arthritis is a chronic autoimmune disorder caused by persistent activation of immune system. Rheumatoid arthritis is the most prevalent form of inflammatory arthritis and always has critical consequences to the joints. Reducing pain, decreasing inflammation and blocking immune response are the main ideas for the treatment of rheumatoid arthritis. There are several therapeutic drugs are available for rheumatoid arthritis: nonsteroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biologic anti-rheumatic drugs. All these drugs are used alone or in combination with methotrexate, which have produced a remarkable impact on the occurrence and development of rheumatoid arthritis. Herein, we summarized the treatment options and some new drugs.

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13. Progress in Synthetic Methodology of Coumarins

Sijin Hang, Yinan Wang, Ruilong Sheng, Ruihua Guo

Medicine Research 2022, 6 (3-4): 220005-220005. DOI: 10.21127/yaoyimr20220005

摘要（162）

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The basic structure of coumarins contain a benzene ring and a pyrone ring, which drive their values on biological research and potential therapeutic properties. In recent years, the synthesis of coumarins and their derivatives have drawn much attention from organic chemists and medicinal chemists. Herein, we summarized recent advances on synthetic methodologies of coumarins from 2011 to 2021.

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14. The Effect and Underlying Mechanism of Sleep Deprivation on Several Gastrointestinal Physiology and Diseases

Yi-Fan Li, Lu-Yu Niu, Jie-Fu Fan, Zhi-Chao Yao, Ling-Yun Shen, Yang-Kai Wang, Ying He

Medicine Research 2024, 8 (1): 230006-230006. DOI: 10.21127/yaoyimr20230006

摘要（82）

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The incidence of sleep deprivation has increased significantly in contemporary society. Gastrointestinal diseases, one of the diseases with high incidence caused by sleep deprivation, are increasingly becoming a serious public health threat worldwide. However, confusion about underlying mechanism by which sleep deprivation exacerbates gastrointestinal dysfunction has always hindered people from carrying out effective clinical treatment. In this paper, we review the effects of sleep deprivation on four gastrointestinal physiology and further reveal the mechanism by which sleep deprivation exacerbates several gastrointestinal diseases, providing a new perspective for people to better understand and treat related diseases.

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15. Acteoside Attenuates Retinal Ganglion Cell Damage in Acute High Intraocular Pressure-Induced Rats via the Bax/Bcl-xL Axis

Xuewei Wang, Yanqing Yang, Yan Li, Chaofei Ba

Medicine Research 2022, 6 (1-2): 220001-220001. DOI: 10.21127/yaoyimr20220001

摘要（186）

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Loss of retinal ganglion cells (RGCs) is the main cause of glaucoma and traumatic optic neuropathy, which can eventually lead to optic nerve atrophy and vision loss. Acteoside is a natural phenylpropanoid glycoside compound with many pharmacological activities, including neuroprotective effects. Studies have shown that acteoside can protect RGCs from damage; however, the underlying mechanism remains unclear. In this paper, we investigated whether acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis. H & E staining showed that acteoside treatment significantly attenuated RGC damage in acute high intraocular pressure-induced rats. Additionally, immunohistochemical staining and immunoblotting analysis demonstrated that acteoside treatment significantly inhibited the expression of Bax and increased the expression of Bcl-xL in retina tissues. Collectively, these findings demonstrate that acteoside attenuates RGC damage in acute high intraocular pressure-induced rats via the Bax/Bcl-xL axis, suggesting that acteoside has a promising potential in glaucoma treatment.

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16. Antibacterial Activity of Extracellular Vesicles from Symbiotic Vaginal Lactobacilli

Lanxi Zheng, Kehai Liu*

Medicine Research 2023, 7 (1-2): 230003-230003. DOI: 10.21127/yaoyimr20230003

摘要（158）

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Vaginal microorganisms, dominated by Lactobacillus spp., are an important defense against infections including pathogenic sexually transmitted infections. Extracellular vesicles (EVs) are recognized and endocytosed by tissue cells through specific interactions between membrane surface proteins, and thereafter deliver their molecular cargo. Bacteria can use their EVs to interact with neighboring bacteria and play an important role in the physiology and pathogenesis of cells. Herein, we investigated whether the bacteriostatic effect of Lactobacillus was mediated by extracellular vesicles released by these bacteria. L. gasseri-derived EVs were isolated by ultracentrifugation and loaded with metronidazole to observe their antibacterial activity. Our results showed that L. gasseri-derived EVs could effectively encapsulate drug, enhanced drug retardation, and had good biosafety. EVs and EVs-metronidazole have inhibitory effects on E. coli, S. aureus, and L. monocytogenes, with the best inhibitory effect on L. monocytogenes. Together, our work provides a new potential strategy for vaginitis treatment.

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17. SARS-CoV-2 Inactivation by Persulfate-Enhanced Silver Ions

Jingyao Zhu, Shuhong Wu, Yanwen Fang, Lin Lin, Jun Zhu

Medicine Research 2022, 6 (1-2): 210013-210013. DOI: 10.21127/yaoyimr20210013

摘要（186）

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The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health concern with over 100 million confirmed cases. Considering the pandemic emergency, new safety strategies must be found against SARS-CoV-2 virus. In present study, a persulfate-enhanced silver ion is obtained against SARS-CoV-2, evidencing its potential as an efficient and rapid alternative for controlling viral spread. The synergistic interacting between Ag ⁺ and K ₂S ₂O ₈ is proposed, which means that K ₂S ₂O ₈ can oxidize +1 of silver ions to a higher valance state and can produce highly oxidative sulfate radical anions (SO ^4-) for a kind of compound disinfectant with silver ions. The persulfate-enhanced silver ion has 99.54% of Anti-SARS- CoV-2 viral activity at a low concentration of 100 ppm and 99.999%, 99.999% and 99.99% of the killing effect on Escherichia coli, Staphylococcus aureus and Candida albicans at a lower concentration of 30 ppm and a short time of 0.5 min. Thus, the obtained materials may be made available for hand hygiene and for disinfection of surfaces, washing equipment of individual protection in hospitals and laboratories, as well as for household use.

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18. Research Advances and Applications of Polysaccharide-Based Complex Hydrogels

Yuting Liu, Yunbo Ge, Chaoyan Zhang

Medicine Research 2023, 7 (1-2): 230005-230005. DOI: 10.21127/yaoyimr20230005

摘要（134）

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This paper introduces research background of polysaccharide-based composite hydrogel materials, discusses definition, classification and preparation of hydrogels, and summarizes research progress of chitosan-based hydrogels, hyaluronic acid-based hydrogels, alginate-based hydrogels, starch-based hydrogels and cellulose-based hydrogels according to different types of polysaccharides. In addition, we summarize the applications of polysaccharide-based complex hydrogels in wound healing, tissue engineering, and drug delivery. Finally, the development opportunities and challenges faced by polysaccharide-based complex hydrogels are summarized, and the future research directions are prospected, hoping to broaden their potential application fields.

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19. Physicochemical Properties and in vitro Digestion Characteristics of Polysaccharide from Auricularia auricula

Min Lei, Yuting Liu, Yunbo Ge, Chaoyan Zhang

Medicine Research 2023, 7 (1-2): 230004-230004. DOI: 10.21127/yaoyimr20230004

摘要（124）

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Auricularia auricula polysaccharide (AAP) was extracted with ethanol of different concentrations (50%, 60%, 70%, 80%, 90%). Taking the yield, total sugar content, and uronic acid content as the indexes, the optimal alcohol precipitation concentration of AAP was 50%, and the polysaccharide content was 58.89%. In vitro digestion experiment showed that the content of reducing sugar in AAP was almost unchanged in the saliva and gastric juice digestion phase. However, the reducing sugar content of AAP increased from 0.062 mg/mL at 0.5 h to 1.162 mg/mL at 3 h during the intestinal juice digestion phase. In addition, in vitro antioxidant results showed that AAP still maintained high 2,2’-azido bis (3-ethyl benzothiazole line-6-sulfonic acid) (ABTS) free radical scavenging activity after digestion.

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20. Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System in Vitro

Xinyi Pu, Boyu Chen, Xiaozhen Diao, Hui Han, Jinhua Hou, Jiudong Hu, Yuhuan Yang, Yuping Zhu, Wenhui Wu

Medicine Research 2023, 7 (3-4): 230011-230011. DOI: 10.21127/yaoyimr20230011

摘要（91）

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Glucokinase (GK), as a key enzyme regulating carbohydrate metabolism, has been widely researched as a therapeutic target for diabetes. This study aimed to investigate the influence of magnesium ion concentration, ATP concentration, and enzyme concentration on the catalytic activity of GK by response surface. A cellular model of insulin resistance (IR) was established to observe the ameliorating effect of magnesium ion on IR by screening the concentration and duration of insulin action. The results indicated that the optimal concentrations for enzyme activity were found to be 1.1 mM for magnesium ion, 1.4 mM for ATP, and 0.5 U/mL for glucokinase. In the presence of taurine, the IR model was treated with magnesium ion (1.1 mM) can promote glucose consumption, GK activity and intracellular magnesium concentration in IR cells. Magnesium ion, as a key factor in GK-catalyzed glycolysis, showed a positive correlation between intracellular magnesium ions and the catalytic activity of GK within a certain concentration range. Therefore, magnesium ion could effectively promote carbohydrate metabolism and alleviate the progression of IR.

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21. Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease

Leandro Louback da Silva, Beatriz de Frias Leite, Emerson Teixeira da Silva, Marcus Vinícius Nora de Souza

Medicine Research 2023, 7 (1-2): 230002-230002. DOI: 10.21127/yaoyimr20230002

摘要（150）

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Alzheimer's disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age of 85. It is responsible for incapacitation of the individual by degrading cognitive functions, and its evolution leads the individual to death after a few years. It is characterized by brain degeneration triggered by several factors. One of the triggering factors is in the acetylcholine system. There is a decrease in the count of this neurotransmitter in individuals with this disease. The involvement of endogenous metal ions such as iron, copper, and zinc has also been involved in neurodegeneration mechanisms, in which there is the formation of radical species that cause oxidative stress, with important contribution of the neutrophil-derived enzyme myeloperoxidase, forming lesions in the neuronal cytoplasm and functional deficiency of neurons. In the present work, we report the evaluation of seventeen Camphor hydrazone derivatives 3a—3q, prepared in accordance with our previous work, as probable inhibitors of myeloperoxidase (MPO), acetylcholinesterase (AChE), and free radical-scavenging, to be used as potential agents against AD. Nine compounds showed significant activity against MPO. Among them, 3j and 3k had 78.4 and 53.9 μM (IC ₅₀), respectively. Three compounds showed stronger activity, 3d, 3k, and 3l with EC ₅₀ of 15.2, 21.3, and 14.4 µM, respectively, for free radical-scavenging activity, being similar to the standard quercetin (12.8 µM). All the final compounds were analyzed for drug-likeness. With exception for 3e and 3p, all were suitable on all filters evaluated. These results show that the compounds of hydrazone class are promising in the search for potential candidates for new agents against AD.

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22. Progress in Antidiabetic Effects of Sesquiterpenoids

Kunyi Zhang, Yi Liu, Feixiang Guo, Huiqin Zheng, Qianqian Sun, Lizhen Fang

Medicine Research 2023, 7 (3-4): 230009-230009. DOI: 10.21127/yaoyimr20230009

摘要（93）

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Sesquiterpenoids have a wide range of physiological activities, and have potent effects against various diseases. In recent years, many sesquiterpenoids have been reported to show significant bioactivities on diabetes mellitus that is an increasingly severe metabolic disease. In this paper, the bioactivities of sesquiterpenoids on diabetes mellitus in the past twenty years are reviewed.

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23. Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems

Zhao Wang, Jingjing Sun, Ruilong Sheng

Medicine Research 2023, 7 (3-4): 230008-230008. DOI: 10.21127/yaoyimr20230008

摘要（125）

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In the past decades, many polyethylene glycol (PEG)-containing polymers were developed and widely utilized to prepare functionalized nano delivery systems with hydrophilic shielding feature and high body fluid/environmental stability. Notably, some surface physicochemical properties of the PEG-containing polymers largely determined their solution properties and interactions with other biomolecules, which thus subsequently influenced their biological behaviors. In this paper, we summarized recent advances on the surface physicochemical properties of PEG-containing polymer nano systems and their impacts on self-assembly, solution stability, biomolecular interactions, as well as drug delivery. Future research outlooks in this area were also stated and discussed.

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24. 2,4-Dinitrophenylhydrazine Pre-column Derivatization: High Performance Liquid Chromatography Determination of Residual Formaldehyde in Pharmaceutical Industry and Key Parameters Analysis

Guoyin Yin, Ruilong Sheng

Medicine Research 2024, 8 (1): 240001-240001. DOI: 10.21127/yaoyimr20240001

摘要（61）

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Formaldehyde is a colorless gas with a pungent odor, and it is commonly used in many industries to produce resins, plastics, textiles, household products, as well as pharmaceutics. Accurate formaldehyde analysis is significant for environmental and industrial control. In this paper, formaldehyde is analyzed as its 2,4-dinitrophenylhydrazine derivative through a high performance liquid chromatography method. The method has been validated for specificity, limit of detection, limit of quantification, linearity and range, precision, accuracy, and solution stability, which showed simplicity, speed, and accuracy, making it well-suited for the determination of traceable levels of formaldehyde in the pharmaceutical industry.

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25. Progress in Anti-Inflammatory Effect of Ellagic Acid

Meiyan Duan, Zemin Xiang, Huanhuan Xu

Medicine Research 2024, 8 (1): 240002-240002. DOI: 10.21127/yaoyimr20240002

摘要（85）

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Inflammation is an adaptive physiological state caused by tissue injury, stress or infection that restores tissue homeostasis. Recent studies have shown that inflammation is a major factor in the progression of various diseases, including arthritis, inflammatory bowel disease, asthma and cancer. Currently, the treatment of inflammatory diseases mainly consists of steroids and non-steroidal anti-inflammatory drugs. However, long term use can lead to serious adverse reactions. In recent years, ellagic acid has received much attention due to its safety and anti-inflammatory activities. In this paper, we review research progress in anti-inflammatory effects of ellagic acid hoping to further understand its effectiveness and provide the guidance for development and application of clinical anti-inflammatory drugs.

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26. A Novel Combined Nanoparticle Delivery of Poly(ADP-Ribose) Polymerase Inhibitor-Olaparib and Copper Complexes for Chemosensitization Therapy in Breast Cancer

Xiaoya Huang, Kehai Liu

Medicine Research 2023, 7 (3-4): 230007-230007. DOI: 10.21127/yaoyimr20230007

摘要（101）

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Chemo-sensitization therapy has gained importance in the field of anti-cancer treatment in recent years. The combination of both chemotherapy and chemosensitization has unique advantages. However, there has been relatively limited research on combination treatment using metal complexes and chemosensitizers. Herein, we reports a two-drug synergistic delivery system combining a copper complex and a chemosensitizer Olaparib in a certain ratio of safety and efficiency is the key. Polyethylenimine (PEI) was chemically-linked to activated chemosensitizer Olaparib, which was connected to a bifunctional peptide, T15, for facilitation and nuclear targeting, resulting in Ola-PEI-T15. Then, a novel metal complex Cu/Ola-PEI-T15 was obtained by Cu ²⁺ coordination to Ola-PEI-T15. The two therapeutic agents can be transported into the cells at the same time, giving full play to the synergistic anti-tumor effect.

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27. Effects of Different Packaging Methods on Freshness of Larimichthys polyactis during Cold Storage

Zibin Ma, Ruihua Guo, Bin Bao, Wenhui Wu

Medicine Research 2024, 8 (1): 240004-240004. DOI: 10.21127/yaoyimr20240004

摘要（76）

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Taking Larimichthys polyactis, a rare seafood from Zhejiang Province, as the research object, sensory evaluation, pH, microbial analysis, texture, water retention, K value, total volatile basic nitrogen (TVB-N value), TCA-soluble peptide, thiobarbiturate acid value, the effects of ordinary packaging, vacuum packaging and air-conditioned packaging on the quality of Larimichthys polyactis during the refrigeration process were studied. The results showed that the sensory comprehensive score, texture and water retention of Larimichthys polyactis were gradually decreased with the extension of refrigeration time. The TVB-N value and TBA value of Larimichthys polyactis under the three different packaging treatments increased with the extension of time, and the change of K value was consistent with the TVB-N value. The TVB-N value, TBA value and K value of Larimichthys polyactis in air-conditioned packaging group increased slowly. The content of TCA-soluble peptide indicated that both vacuum and air-conditioned packages had a good effect on inhibiting protein degradation. According to the evaluation indexes, the air conditioning package is beneficial to keep the freshness of Larimichthys polyactis under the cold storage condition.

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28. Contents: Med. Res. 3-4/2022

Medicine Research 2022, 6 (3-4): 0-.

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29. A Perspective of 6,12-Guaianolides and Their Analogues: Synthesis, Bioactivity and Structure-Activity Relationships

Ruihua Guo, Guo Y. Yin, Ruilong Sheng

Medicine Research 2024, 8 (1): 230010-230010. DOI: 10.21127/yaoyimr20230010

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Recently, the study on 6,12-guaianolides, a family of natural guaiane-type sesquiterpenoids, has attracted increased attention in the field of chemical synthesis, pharmaceutics, and medicinal chemistry. Many 6,12-guaianolide compounds and their analogues showed remarkable molecular diversity, structural modifiability, and versatile biological and pharmacological properties, such as anticancer, antivirus, anti-inflammatory, endogenous NO production inhibition, and so on. In this paper, we summarized recent advances on the synthesis methods of 6,12-guaianolides and their analogues, briefly described their bioactivities, and elucidated the quantitative structure-activity relationship of some 6,12-guaianolides and their analogues. Furthermore, the perspectives of 6,12-guaianolides and their analogues were discussed.

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30. Contents: Med. Res. 1-2/2022

Medicine Research 2022, 6 (1-2): 0-.

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31. Contents: Med. Res. 3-4/2023

Medicine Research 2023, 7 (3-4): 0-0.

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32. Contents: Med. Res. 1-2/2023

Medicine Research 2023, 7 (1-2): 0-0.

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33. Contents: Med. Res. 1/2024

Medicine Research 2024, 8 (1): 0-0.

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