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1.

Natural Products from the genus Daldinia and Their Bioactivities

Jing Li, Luohao Li, Runqing Zhu, Vuanghao Lim, Qianqian Sun, and Lizhen Fang

Medicine Research 2021, 5 (3-4): 210005-210005. DOI: 10.21127/yaoyimr20210005

摘要（280）

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Genus Daldinia is a unique source of natural products, which possess many pharmacological effects such as antibacterial activity, cytotoxicity, antioxidant activity, α-glucosidase inhibitory activity, and so on. Recently, most studies of genus Daldinia were focused on D.eschscholzii, D.concentrica and D.sp. This paper covers nearly a decade of research on Daldinia, focusing on the chemical structures and related biological activities of the secondary metabolites produced.

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2.

Progress in Terpenes from Genus Paeonia

Lei Sun, Chuihao Kong, Huan Zhao, Deling Wu, Fengqing Xu

Medicine Research 2021, 5 (3-4): 210011-210011. DOI: 10.21127/yaoyimr20210011

摘要（208）

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Paeonia is the single genus of ca. 35 known species in the family Paeoniaceae. Up to now, more than 185 terpenes have been isolated from root/root cortex, flowers and seeds of the genus Paeonia. Researches had focused on the following species, such as P. lactiflora, P. suffruticosa Andr, P. veitchii, P. labiflora, P. delavayi, P. rockii, P. emodi, P. peregrina, and P. japonica. In this paper, the terpenes of Paeonia were reviewed, which may provide more useful information for further development on this genus.

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3. Progress in Chemical Compositions and Pharmacological Activities of Althaea officinalis

Tao-Tao Xue, Hong-Bo Xu, Zhi-Shu Tang, Jin-Ao Duana, Hong-Bo Liu, Xin-Bo Shi, and Zhong-Xing Song

Medicine Research 2021, 5 (2): 210002-210002. DOI: 10.21127/yaoyimr20210002

摘要（644）

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Althaea officinalis (Malvaceae), mainly distributed in Europe and China, is an ornamental, edible and medicinal plant, which is effective in reducing cough and phlegm. To better develop and utilize A. officinalis, 46 kinds of compounds including flavonoids, phenolic acids, steroids, coumarins and other types isolated from this plant are summarized, and their pharmacological effects such as anti-tussive, anti-inflammatory, anti-oxidation, anti-bacterial and anti-fungal activities are discussed in this review.

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4. Mechanism of Interaction between Phenolic Compounds and Proteins Based on Non-Covalent and Covalent Interactions

Qianqian Chu, Bin Bao, Wenhui Wu

Medicine Research 2018, 2 (3): 180014-. DOI: 10.21127/yaoyimr20180014

摘要（842）

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Phenolic compounds are widely used in natural plant foods and have strong antioxidant properties, so they are widely used in food and medicine. The reaction between the phenolic compound and the protein can affect the functional properties of the protein, such as emulsifying properties, gel properties, solubility, thermal stability, and foaming properties. The mechanism of interaction between phenolic compounds and proteins are described from the aspects of non-covalent interaction and covalent interaction, and the characterization methods of the interaction mechanism between phenolic compounds and proteins are described. The indexes for characterizing the covalent bonding of phenolic compounds and proteins include the free amino group content, total sulfhydryl content, tryptophan content. Ninhydrin method, 2,4,6-trinitrobenzenesulfonic acid (TNBS) method, o-phthal- aldehyde (OPA) method and high-performance liquid phase chromatography were applied to o measure the free amino group content. Ellman’s method was applied to investigate total sulfhydryl content. Fluorescence measurements can be used for changes in tryptophan modification. The indexes for characterizing the con-covalent bonding of phenolic compounds and proteins include hydrogen bonding, hydrophobic interactions, disulfide bonds and hydrophobicity of protein surface. Hydrogen bonding, hydrophobic interactions and disulfide bonds can be investigated by Gómez-Guillén’s method. ANS fluorescent probe method was applied to measure the changes of hydrophobicity of protein surface.

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5. An Update on Chemical Constituents from Nicotiana tabacum L. and Their Bioactivities from 2017 to 2020

Kuo Xu, Qian Liu, Lin Ni, Yong-Mei Du and Zhong-Feng Zhang

Medicine Research 2020, 4 (4): 200019-200019. DOI: 10.21127/yaoyigc20200019

摘要（304）

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^{Nicotiana tabacum} L., well known as tobacco, could be not only used for raw materials of producing cigarettes, but also as a folk Chinese herbal medicine. This paper offers a systematic review of newly reported compounds from N. tabacum over the past four years covering the literatures from the beginning of 2017 through the end of 2020 and describes their structural diversities and bioactivities. A total of 46 natural compounds and 42 references were updated and compiles in this review, which may be of interest to pharmacognosists and natural products chemists.

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6. Progress in Phytochemical and Bioactivities of Coffea arabica L.

Xiao-Jing Shen, Zhu-Bin Zhou, Fan-Qiu Nie, Cheng-Ting Zi, and Jiang-Ping Fan

Medicine Research 2020, 4 (3): 200012-. DOI: 10.21127/yaoyimr20200012

摘要（588）

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Coffea arabica L. is a famous specie in genus caffee for medicinal treatment and diet with wide distribution and rich resources. It contains rich alkaloids, flavonoids and terpenes, which exhibited antioxidation, anti-inflammatory, antitumor, antidiabetic, live protection, and neuroprotective activities. Herein, we summarized the progress in the chemical constituents and bioactivities of C. arabica L. to provide ideas for medicinal development prospects of C. arabica L.

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7. Progress in Skin Care Efficacy of Lactoferrin

Tong Xie, Wu Qiao, Tinghan Jia, and Ken Kaku

Medicine Research 2022, 6 (1-2): 210015-210015. DOI: 10.21127/yaoyimr20210015

摘要（354）

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Lactoferrin is an iron-binding glycoprotein with a variety of biological activities, including anti-inflammatory, antibacterial, antitumor, antiviral, whitening, repairing skin damage caused by inflammation, immune regulation, and osteogenic activity. As a protein with great development potential, lactoferrin is widely used in the fields of food, medicine and cosmetics. The effect of lactoferrin on the skin is particularly prominent, and it has the potential to be used as a new raw material for skin care products. Researchers have reviewed biological activities of lactoferrin and its microbial mechanism of action. Therefore, this article focuses on the skin care efficacy of lactoferrin. This article reviews the latest research results of lactoferrin in skin care efficacy.

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8. Renoprotective Effect of Sulphate Polysaccharide from Brown Algae on Ethylene Glycol-Induced Renal Damage in Rats

Hui Huang, Junwen Wang, Xueyan Li, Wenhui Wu, Kejin Shi, and Chaoyan Zhang

Medicine Research 2020, 4 (1-2): 190010-190010. DOI: 10.21127/yaoyimr20190010

摘要（170）

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The protective effect of the polysaccharides on ethylene glycol induced kidney impairment has been explored. Polysaccharides have been extracted from Sargassum graminifolium, which belongs to brown algae. Three different doses of polysaccharides were used for rats with kidney stones by ethylene glycol feeding. Then, urinary biochemistry parameters, renal function factors including blood urea nitrogen (BUN) and serum creatinine (Scr) levels were detected. Besides, interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) in kidney tissue were elevated, which belong to proinflammatory cytokines. Moreover, kidney histopathological sections were examined. The results illustrated that polysaccharides not only increased calcium level but also decreased oxalate, Scr, and BUN levels. In addition, the levels of IL-6 and TNF-α were reduced. Moreover, renal micro-scopic analysis showed polysaccharides treatment alleviated observably calcium oxalate deposits in the kidney tissue. The results indicated that the renoprotective mechanism of SGP may be attributed to suppression of inflammation, reducing the growth of urinary stones and improving kidney function in vivo, which explained SGP through multiple ways to protect kidney cells from damaging of hyperoxaluria rats.

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9. Magnesium Ion-Dependent Activation of Glucokinase in Simulated Cytoplasmic System in Vitro

Xinyi Pu, Boyu Chen, Xiaozhen Diao, Hui Han, Jinhua Hou, Jiudong Hu, Yuhuan Yang, Yuping Zhu, Wenhui Wu

Medicine Research 2023, 7 (3-4): 230011-230011. DOI: 10.21127/yaoyimr20230011

摘要（91）

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Glucokinase (GK), as a key enzyme regulating carbohydrate metabolism, has been widely researched as a therapeutic target for diabetes. This study aimed to investigate the influence of magnesium ion concentration, ATP concentration, and enzyme concentration on the catalytic activity of GK by response surface. A cellular model of insulin resistance (IR) was established to observe the ameliorating effect of magnesium ion on IR by screening the concentration and duration of insulin action. The results indicated that the optimal concentrations for enzyme activity were found to be 1.1 mM for magnesium ion, 1.4 mM for ATP, and 0.5 U/mL for glucokinase. In the presence of taurine, the IR model was treated with magnesium ion (1.1 mM) can promote glucose consumption, GK activity and intracellular magnesium concentration in IR cells. Magnesium ion, as a key factor in GK-catalyzed glycolysis, showed a positive correlation between intracellular magnesium ions and the catalytic activity of GK within a certain concentration range. Therefore, magnesium ion could effectively promote carbohydrate metabolism and alleviate the progression of IR.

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10. Progress in Phytochemical and Bioactivities of Areca catechu L

Zhenshuai Tang, Jifeng Liu

Medicine Research 2022, 6 (3-4): 220004-220004. DOI: 10.21127/yaoyimr20220004

摘要（251）

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Areca catechu L is a genus of plants whose leaves and fruits can be used as folk medicine. The chemical composition of A. catechu can be divided into alkaloids, flavonoids, tannins, terpenoids, sterols, fatty acids, etc. It has pharmacological effects such as anti-inflammatory, antioxidant, antibacterial, antidepressant, hypotensive, etc., while having toxic side effects such as oral toxicity, hepatotoxicity and addiction. This paper reviews the progress of research on chemical composition and pharmacological effects and toxic side effects of A. catechu, and provides new ideas for subsequent development of A. catechu.

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11. Antibacterial Activity of Extracellular Vesicles from Symbiotic Vaginal Lactobacilli

Lanxi Zheng, Kehai Liu*

Medicine Research 2023, 7 (1-2): 230003-230003. DOI: 10.21127/yaoyimr20230003

摘要（158）

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Vaginal microorganisms, dominated by Lactobacillus spp., are an important defense against infections including pathogenic sexually transmitted infections. Extracellular vesicles (EVs) are recognized and endocytosed by tissue cells through specific interactions between membrane surface proteins, and thereafter deliver their molecular cargo. Bacteria can use their EVs to interact with neighboring bacteria and play an important role in the physiology and pathogenesis of cells. Herein, we investigated whether the bacteriostatic effect of Lactobacillus was mediated by extracellular vesicles released by these bacteria. L. gasseri-derived EVs were isolated by ultracentrifugation and loaded with metronidazole to observe their antibacterial activity. Our results showed that L. gasseri-derived EVs could effectively encapsulate drug, enhanced drug retardation, and had good biosafety. EVs and EVs-metronidazole have inhibitory effects on E. coli, S. aureus, and L. monocytogenes, with the best inhibitory effect on L. monocytogenes. Together, our work provides a new potential strategy for vaginitis treatment.

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12.

Progress in Chemical Constituents and Bioactivities of Perilla frutescens (L.) Britt

Hui Fang, Shudan Zheng, Jifeng Liu

Medicine Research 2021, 5 (3-4): 210008-210008. DOI: 10.21127/yaoyimr20210008

摘要（344）

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Perilla frutescens (L.) Britt is an annual herb of the genus Perilla in the labiaceae. Its leaves, stalks and fruits can be used as folk medicine. The chemical components in Perilla frutescens (L.) Britt can be divided into volatile oil, terpenoids, triterpenoids, steroids, glycosides, phenylpropanoids and phenolic acids, flavonoids and pigments, which have anti-allergy, antibacterial, hypolipidemia, antioxidation, antitumor, antitussive and antipyretic activities. In this paper, we reviewed research progress of chemical constituents and pharmacological effects of Perilla frutescens to provide new ideas for subsequent development of Perilla frutescens (L.) Britt.

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13. Recent Advances on Drug Treatments of Rheumatoid Arthritis

Chunxia Gan, Mingzhen Yu, Ergu Chen, Xuanjun Wang, Huanhuan Xu

Medicine Research 2022, 6 (1-2): 210012-210012. DOI: 10.21127/yaoyimr20210012

摘要（211）

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Rheumatoid arthritis is a chronic autoimmune disorder caused by persistent activation of immune system. Rheumatoid arthritis is the most prevalent form of inflammatory arthritis and always has critical consequences to the joints. Reducing pain, decreasing inflammation and blocking immune response are the main ideas for the treatment of rheumatoid arthritis. There are several therapeutic drugs are available for rheumatoid arthritis: nonsteroidal anti-inflammatory drugs, disease-modifying anti-rheumatic drugs, and biologic anti-rheumatic drugs. All these drugs are used alone or in combination with methotrexate, which have produced a remarkable impact on the occurrence and development of rheumatoid arthritis. Herein, we summarized the treatment options and some new drugs.

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14. Plant-Derived Kavalactones and Their Bioactivities

Nenling Zhang, Linjing Wu, Xiang Liu, Xiangchun Shen

Medicine Research 2018, 2 (1): 170019-3. DOI: 10.21127/yaoyimr20170019

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Kavalactones, mainly found in Piper methysticum, are a class of lactone compounds usually with an arylethylene-pyrone skeleton. Till now, fifty-one kavalactones have been isolated from the genera Piper, Alpinia, Amomum, Polygala, Goniothalamus, and Dumortiera. The bioactivities of six kavalactones, kawain, 7,8-dihydro- kawain, methysticin, dihydromethysticin, yangonin, and desmethoxyyagonin, have been studied extensively. This review aims to give an overview of kavalactones in the plants and their various bioactivities.

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15. Recent Advances on anti-MRSA Natural Products Derived from Plants

Jing Guo, Xiaoyu Su, Tianfang Ma, Jifeng Liu

Medicine Research 2018, 2 (1): 170018-5. DOI: 10.21127/yaoyimr20170018

摘要（504）

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Methicillin-resistant Staphylococcus aureus (MRSA) is a multi-drug resistant pathogenic bacteria, which has seriously threatened human health for a long time. Therefore, there is an urgent and unmet demand for new types of antibiotics. In response to the antibiotic resistance, many researchers have studied natural products derived from plant for alternative antibiotics and therapies. In this review, we summarized recent advances on anti-MRSA natural products from plants and their potential antibacterial effect against MRSA as potential anti-MRSA agents since 2007.

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16. Pharmacist Intervention with Computer-Based Alert System and Assessment of Prescription Errors for Outpatient in a Chinese Tertiary Hospital

Qing Shen, Yi-Meng Zhou, Jin Lv, Hua Yang, Yuan-yuan He, Yuan Bian, Yong Han

Medicine Research 2021, 5 (3-4): 210009-210009. DOI: 10.21127/yaoyimr20210009

摘要（147）

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Qualified prescribing is fundamental for appropriate use of medicine. Pharmacist interventions potentially remind physicians to cope with this issue. This study aimed to report interventions implemented by pharmacists with real-time computer-based alert system and evaluate the prescription errors for outpatients in a Chinese tertiary hospital. This retrospective, non-comparative study was implemented with an analysis of data collected from October to December in 2018 involved all clinical specialty departments in the hospital. Alerts were generated and displayed on pharmacist screen while prescribing inappropriately, then pharmacists chose certain operation and offered recommendations according to the alerts. Outcomes such as category and acceptance rate of pharmacist recommendations, prescription error types, prevalence rate, severity level and monthly tendency were documented, categorized and analyzed. In our study, 2.3% of prescriptions generated alerts, and incidence of pharmacist interventions was 0.19%. 431 prescription errors were prevented, with the overall acceptance rate of interventions accounted for 29.7%. Dosage or frequency problems ( n = 170, 39.5%), contraindications ( n = 79, 18.3%) and improper duration of pharmacotherapy ( n = 53, 12.3%) were the top three types of prescription errors. Monthly rate of errors decreased from 0.98 to 0.43 per 1000 prescriptions in the monitoring period. Pharmacist interventions with computer-based alert system were available for filtering part of invalid alerts and preventing prescription errors in our study.

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17. Progress in Chemical Constituents and Pharmacological Effects of Citrus medica L. var. sarcodactylis Swingle

Shuyu Xu, Yin Qu, Xinyu Liu, Yao Li, Jimin Liu, Hezhong Jiang

Medicine Research 2020, 4 (1-2): 190014-190014. DOI: 10.21127/yaoyimr20190014

摘要（338）

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Citrus medica L. var. sarcodactylis Swingle is known as Foshou fruit that can be used as Chinese medicinal materials and has a health and longevity effect. In recent years, investigations about the chemical compounds of Citrus medica L. var. sarcodactylis Swingle have shown that its main compounds include flavonoids, essential oils, coumarins, and polysaccharides, with anti-inflammatory, antimicrobial, antioxidant activity, effect on the autonomic nervous system, and other pharmacological effects. In this paper, the chemical compositions and pharmacological effects of Citrus medica L. var. sarcodactylis Swingle are summarized.

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18. Progress on Design of Emulsion Delivery System for Insoluble Bioactive Substances

Xueyan Li, Junwen Wang, Chaoyan Zhang

Medicine Research 2019, 3 (4): 200002-. DOI: 10.21127/yaoyimr20200002

摘要（213）

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The appropriate delivery system is necessary for insoluble bioactive substances with poor water solubility, instability and low bioavaiability. The delivery system is key to improve its application characteristics. In terms of improving bioavailability of insoluble substances, emulsions have great advantages over other delivery systems. In this paper, the present researches on emulsion carrier systems of insoluble substances are reviewed including carotenoids, anthraquinones, diketone compounds, flavonoids, etc. At the same time, a summary on the development of insoluble substances food and drugs is presented, which is beneficial to the improvement of the research technology in this field.

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19. Flavonoids, Phenylethanoids and Phenylpropanoids from Rhodiola rosea L. and Their Lipid-Lowering Activities on Receptor 5-HT _2A

Hao Wang, Ji-Lei Liang, Qing-Ming He, Guo-Hai Zhou, Cun-Fu Li, Ping-He Wei, and Hao-Yan Dong

Medicine Research 2020, 4 (4): 200018-200018. DOI: 10.21127/yaoyimr20200018

摘要（261）

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20. Chemical Research on Limonoids Isolated from the Fruits of Melia toosendan

Hao Wang, Hao-Yan Dong, Yan-Fang Liu, Yu-Xiang Ma, Wei Wang, Zhi-Mou Guo and Chao-Ran Wang

Medicine Research 2022, 6 (1-2): 210014-210014. DOI: 10.21127/yaoyimr20210014

摘要（152）

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As the characteristic components from the fruits of Melia toosendan, limonoids attract continuous research interest for their chemistry and biodiversity, and their analogues are continuously obtained from this plant. Thus, limonoids isolated from the fruits of M. toosendan were investigated, classified and the biogenic metabolic pathway were supposed to provide more information for further research on the title plant.

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21. Recent Advances on Anticancer Effects and Molecular Mechanisms of Maslinic Acid

Jin Li, Xiaomei Yang, Wei Jiang, Qianqian Hu, Xuanjun Wang, Huanhuan Xu

Medicine Research 2022, 6 (3-4): 220002-220002. DOI: 10.21127/yaoyimr20220002

摘要（219）

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Cancer has become a serious public health concern that affects millions of individuals annually in the world. Surgical resection, chemotherapy and radiotherapy have been considered as the standard treatment strategies for different kinds of cancers. Among them, chemotherapeutic agents are usually used for the treatment of malignancies but toxic side effects and drug resistance limit their clinical efficacy. Natural compounds isolated from medicinal plants are excellent and reliable sources of new anticancer drugs. Maslinic acid is a naturally occurred pentacyclic triterpenoid with anticancer activities. This review mainly focuses on recent advances on anticancer effects and molecular mechanisms of maslinic acid and will hopefully provide valuable insights into clinical application of maslinic acid to the treatment of cancers.

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22. Preparation of Ti Doped Nano-ZnO Dispersion and Their Application in Deodorization and Antibiosis

Lin Lin, Shuhong Wu, Xiaoyan Wu, Zheng Zhu, Yongxin Wu, Jun Zhu

Medicine Research 2022, 6 (3-4): 220003-220003. DOI: 10.21127/yaoyimr20220003

摘要（167）

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To develop an effective deodorant and antibacterial agent, we prepare a Ti doped nano-ZnO through a low temperature hydrothermal route. The shape and size of these as-prepared samples can be tuned effectively by controlling the reaction conditions, such as the molar ratio of Ti/Zn. Furthermore, the sample with an appropriate portion of Ti and Zn is selected to obtain dispersion for improving sample activity and avoiding sample agglomeration. XRD, SEM, EDX and DLS are performed to characterize the structure and morphology of samples. Furthermore, the typical dispersion is used to remove odorous molecules and kill bacteria. The results show that polycarboxylic acid can be used to improve the dispersibility and stability of nanoparticles, and the well-dispersed dispersion is high effective for deodorization and antibiosis. Moreover, CCK-8 assays are performed to evaluate the cytotoxicity of dispersions with different size. The result reveals that dispersion with a smaller particle size displayed more serious toxicity. Thus, we suggest that the obtained dispersion can be used as a deodorant and antibacterial agent, but it is necessary to take precautions when handling the dispersion because the nanoparticles, special smaller nanoparticles is more likely to cause serious cytotoxicity.

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23. A Novel Combined Nanoparticle Delivery of Poly(ADP-Ribose) Polymerase Inhibitor-Olaparib and Copper Complexes for Chemosensitization Therapy in Breast Cancer

Xiaoya Huang, Kehai Liu

Medicine Research 2023, 7 (3-4): 230007-230007. DOI: 10.21127/yaoyimr20230007

摘要（101）

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Chemo-sensitization therapy has gained importance in the field of anti-cancer treatment in recent years. The combination of both chemotherapy and chemosensitization has unique advantages. However, there has been relatively limited research on combination treatment using metal complexes and chemosensitizers. Herein, we reports a two-drug synergistic delivery system combining a copper complex and a chemosensitizer Olaparib in a certain ratio of safety and efficiency is the key. Polyethylenimine (PEI) was chemically-linked to activated chemosensitizer Olaparib, which was connected to a bifunctional peptide, T15, for facilitation and nuclear targeting, resulting in Ola-PEI-T15. Then, a novel metal complex Cu/Ola-PEI-T15 was obtained by Cu ²⁺ coordination to Ola-PEI-T15. The two therapeutic agents can be transported into the cells at the same time, giving full play to the synergistic anti-tumor effect.

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24. 2,4-Dinitrophenylhydrazine Pre-column Derivatization: High Performance Liquid Chromatography Determination of Residual Formaldehyde in Pharmaceutical Industry and Key Parameters Analysis

Guoyin Yin, Ruilong Sheng

Medicine Research 2024, 8 (1): 240001-240001. DOI: 10.21127/yaoyimr20240001

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Formaldehyde is a colorless gas with a pungent odor, and it is commonly used in many industries to produce resins, plastics, textiles, household products, as well as pharmaceutics. Accurate formaldehyde analysis is significant for environmental and industrial control. In this paper, formaldehyde is analyzed as its 2,4-dinitrophenylhydrazine derivative through a high performance liquid chromatography method. The method has been validated for specificity, limit of detection, limit of quantification, linearity and range, precision, accuracy, and solution stability, which showed simplicity, speed, and accuracy, making it well-suited for the determination of traceable levels of formaldehyde in the pharmaceutical industry.

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25. Applications of Simple Nanoparticle Zeolitic Imidazolate Framework-8 in Bio-medicine

Zhaokun Zhang, Yan Xu, Kunfeng Zhao, Ying Zhang, Weijia Chen, Xiaodi Li, Yanxia Meng, Dicheng Yang, Ping Wang, Jun Zhu

Medicine Research 2019, 3 (3): 190008-0. DOI: 10.21127/yaoyimr20190008

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26. Surface Physicochemical Properties of Polyethylene Glycol-Containing Polymer Nano Systems

Zhao Wang, Jingjing Sun, Ruilong Sheng

Medicine Research 2023, 7 (3-4): 230008-230008. DOI: 10.21127/yaoyimr20230008

摘要（125）

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In the past decades, many polyethylene glycol (PEG)-containing polymers were developed and widely utilized to prepare functionalized nano delivery systems with hydrophilic shielding feature and high body fluid/environmental stability. Notably, some surface physicochemical properties of the PEG-containing polymers largely determined their solution properties and interactions with other biomolecules, which thus subsequently influenced their biological behaviors. In this paper, we summarized recent advances on the surface physicochemical properties of PEG-containing polymer nano systems and their impacts on self-assembly, solution stability, biomolecular interactions, as well as drug delivery. Future research outlooks in this area were also stated and discussed.

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27. Progress in Bioactivities of Phlorotannins from Sargassumi

Jiaoyang Li, Yuxin Wang, Ruihua Guo, Bin Bao, Wenhui Wu

Medicine Research 2018, 2 (1): 180001-5. DOI: 10.21127/yaoyimr20180001

摘要（384）

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Bioactive components of marine species have received great attention in recent years, especially phlorotannins isolated from brown algae. This paper summarized progress in the structures and bioactivities of phlorotannins including antibacterial, antioxidant, anticoagulant, anti-diabetic, anti-hypertensive, inhibiting HIV, anti-tumor, anti-allergic, anti-inflammatory, defense activity, and deodorant activities.

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28. Triterpenes from the genus Ficus and Their Bioactivities

Qinru Zhou, Na Mao, Yan Chen, Shiquan Gan, Linjing Wu, Xiangchun Shen, Nenling Zhang

Medicine Research 2019, 3 (1): 190004-. DOI: 10.21127/yaoyimr20190004

摘要（242）

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Triterpenoids exist commonly in the genus Ficus. Till now, ninety-seven triterpenes have been isolated from the genus Ficus. The bioactivities of five triterpenes including maslinic acid, oleanolic acid, lupeol, betulinic acid and ursolic acid have been studied extensively. Herein, we provide an overview of triterpenes in the genus Ficus and their various bioactivities.

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29. Progress in Chemical Constituents and Bioactivities of Broussonetia pa-pyrifera (L.) Vent

Fang Li, Tingyu Wen, Jifeng Liu

Medicine Research DOI: 10.21127/yaoyimr20190005
预出版日期: 2019-06-18

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30. Prodrug Systems (II): A Perspective of Polymer-Based Doxorubicin Prodrug Systems towards Chemotherapy

Zhao Wang, Filipe Olim, Jingjing Sun, Ana Rute Neves, Fátima Mendes, Helena Tomás, and Ruilong Sheng

Medicine Research 2021, 5 (1): 200023-200023. DOI: 10.21127/yaoyimr20200023

摘要（237）

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31. Chemical Constituents and Bioactivities of Aconitum episcopale

Xiaojing Shen, Hong Wang, Jiao Cai, Zhubin Zhou, and Fanqiu Nie

Medicine Research 2021, 5 (2): 210001-210001. DOI: 10.21127/yaoyimr20210001

摘要（193）

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Aconitum episcopale Levl., known as a characteristic Aconitum specie in China, is a perennial herbaceous plant classified into Aconitum L. (Ranunculaceae), which mainly distributes in northwest Yunnan and southwestern Sichuan. As a commonly traditional Chinese medicine, the root of A. episcopale has been used to treat anemofrigid-damp arthralgia, arthralgia, cold hernia and anesthesia analgesia with the effects of expelling wind and removing damness, warming menstruation and relieving pain. It also is used for solving other Aconitums poisoning in folk. In order to obtain more information for research and development of A. episcopale, the chemical components and pharmacological research on A. episcopale were reviewed. It is beneficial for future research, development and utilization of Aconitum and search for traditional herbal resources.

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32. SARS-CoV-2 Inactivation by Persulfate-Enhanced Silver Ions

Jingyao Zhu, Shuhong Wu, Yanwen Fang, Lin Lin, Jun Zhu

Medicine Research 2022, 6 (1-2): 210013-210013. DOI: 10.21127/yaoyimr20210013

摘要（186）

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The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has become a global health concern with over 100 million confirmed cases. Considering the pandemic emergency, new safety strategies must be found against SARS-CoV-2 virus. In present study, a persulfate-enhanced silver ion is obtained against SARS-CoV-2, evidencing its potential as an efficient and rapid alternative for controlling viral spread. The synergistic interacting between Ag ⁺ and K ₂S ₂O ₈ is proposed, which means that K ₂S ₂O ₈ can oxidize +1 of silver ions to a higher valance state and can produce highly oxidative sulfate radical anions (SO ^4-) for a kind of compound disinfectant with silver ions. The persulfate-enhanced silver ion has 99.54% of Anti-SARS- CoV-2 viral activity at a low concentration of 100 ppm and 99.999%, 99.999% and 99.99% of the killing effect on Escherichia coli, Staphylococcus aureus and Candida albicans at a lower concentration of 30 ppm and a short time of 0.5 min. Thus, the obtained materials may be made available for hand hygiene and for disinfection of surfaces, washing equipment of individual protection in hospitals and laboratories, as well as for household use.

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33. Evaluation of Camphor Hydrazone Derivatives as Inhibitors of Myeloperoxidase and Acetylcholinesterase Enzymes: Targets for the Development of Agents against Alzheimer’s Disease

Leandro Louback da Silva, Beatriz de Frias Leite, Emerson Teixeira da Silva, Marcus Vinícius Nora de Souza

Medicine Research 2023, 7 (1-2): 230002-230002. DOI: 10.21127/yaoyimr20230002

摘要（150）

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Alzheimer's disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age of 65 and nearly 50% of those over the age of 85. It is responsible for incapacitation of the individual by degrading cognitive functions, and its evolution leads the individual to death after a few years. It is characterized by brain degeneration triggered by several factors. One of the triggering factors is in the acetylcholine system. There is a decrease in the count of this neurotransmitter in individuals with this disease. The involvement of endogenous metal ions such as iron, copper, and zinc has also been involved in neurodegeneration mechanisms, in which there is the formation of radical species that cause oxidative stress, with important contribution of the neutrophil-derived enzyme myeloperoxidase, forming lesions in the neuronal cytoplasm and functional deficiency of neurons. In the present work, we report the evaluation of seventeen Camphor hydrazone derivatives 3a—3q, prepared in accordance with our previous work, as probable inhibitors of myeloperoxidase (MPO), acetylcholinesterase (AChE), and free radical-scavenging, to be used as potential agents against AD. Nine compounds showed significant activity against MPO. Among them, 3j and 3k had 78.4 and 53.9 μM (IC ₅₀), respectively. Three compounds showed stronger activity, 3d, 3k, and 3l with EC ₅₀ of 15.2, 21.3, and 14.4 µM, respectively, for free radical-scavenging activity, being similar to the standard quercetin (12.8 µM). All the final compounds were analyzed for drug-likeness. With exception for 3e and 3p, all were suitable on all filters evaluated. These results show that the compounds of hydrazone class are promising in the search for potential candidates for new agents against AD.

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34. Physicochemical Properties and in vitro Digestion Characteristics of Polysaccharide from Auricularia auricula

Min Lei, Yuting Liu, Yunbo Ge, Chaoyan Zhang

Medicine Research 2023, 7 (1-2): 230004-230004. DOI: 10.21127/yaoyimr20230004

摘要（124）

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Auricularia auricula polysaccharide (AAP) was extracted with ethanol of different concentrations (50%, 60%, 70%, 80%, 90%). Taking the yield, total sugar content, and uronic acid content as the indexes, the optimal alcohol precipitation concentration of AAP was 50%, and the polysaccharide content was 58.89%. In vitro digestion experiment showed that the content of reducing sugar in AAP was almost unchanged in the saliva and gastric juice digestion phase. However, the reducing sugar content of AAP increased from 0.062 mg/mL at 0.5 h to 1.162 mg/mL at 3 h during the intestinal juice digestion phase. In addition, in vitro antioxidant results showed that AAP still maintained high 2,2’-azido bis (3-ethyl benzothiazole line-6-sulfonic acid) (ABTS) free radical scavenging activity after digestion.

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35. Progress in Anti-Inflammatory Effect of Ellagic Acid

Meiyan Duan, Zemin Xiang, Huanhuan Xu

Medicine Research 2024, 8 (1): 240002-240002. DOI: 10.21127/yaoyimr20240002

摘要（85）

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Inflammation is an adaptive physiological state caused by tissue injury, stress or infection that restores tissue homeostasis. Recent studies have shown that inflammation is a major factor in the progression of various diseases, including arthritis, inflammatory bowel disease, asthma and cancer. Currently, the treatment of inflammatory diseases mainly consists of steroids and non-steroidal anti-inflammatory drugs. However, long term use can lead to serious adverse reactions. In recent years, ellagic acid has received much attention due to its safety and anti-inflammatory activities. In this paper, we review research progress in anti-inflammatory effects of ellagic acid hoping to further understand its effectiveness and provide the guidance for development and application of clinical anti-inflammatory drugs.

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36. Diterpenoids from the genus Illicium and Their Bioactivities

Yingying Fu, Junyan Chu, and Jifeng Liu

Medicine Research 2020, 4 (1-2): 200005-200005. DOI: 10.21127/yaoyimr20200005

摘要（274）

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Diterpenoids are important chemical constituents isolated from the genus Illicium, which possess many pharmacological effects such as anti-inflammatory, antiviral activities, cytotoxicity, and so on. Up to now, 68 diterpenoids have been isolated from the genus Illicium, and they are classified as abietane-type, pimarane-type and podocarpane-type. In this paper, the chemical constituents and bioactivities of the diterpenoids from the genus Illicium are reviewed.

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37. Recent Advances on Small-Molecule Epidermal Growth Factor Receptor Inhibitors

Bo-Ya Shi, Ze-Hao Wang, Xuan-Jun Wang Jun Sheng, and Cheng-Ting Zi

Medicine Research 2020, 4 (3): 200011-. DOI: 10.21127/yaoyimr20200011

摘要（424）

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The epidermal growth factor receptor (EGFR) is a kind of cell membrane surface receptor with tyrosine kinase activity, which is closely related to the growth, proliferation, differentiation, apoptosis, metastasis and other processes of tumor cells. Targeting EGFR tyrosine kinase inhibitors has become a hot topic for drug development for treatment of non-small-cell cancer (NSCLC). Herein, we summarized recent advances on the targeted therapeutic drugs for NSCLC in recent years.

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38. Phytochemical and Biological Progress of Cynanchum paniculatum

Liangyan Liu, Chang-An Geng

Medicine Research 2019, 3 (1): 190200-. DOI: 10.21127/yaoyimr20190200

摘要（193）

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Cynanchum paniculatum (Xuchangqing) is a famous traditional Chinese herb (TCH) widely used for treating rheumatism and pains in China. C ₂₁ steroids and acetophenones are the characteristic constituents in this TCH, from which a total of 61 compounds have been reported involving 32 C ₂₁ steroids, 13 phenols, seven triterpenoids and nine other compounds. Biological investigation on this herb revealed the anti-inflammatory, anti-snake venom, anti-microbial, neuroprotective and anti-cancer properties of the pure compounds or crude extracts. This minireview summarized the phytochemical and biological progress of C. paniculatum to provide a reference for better understanding the effective substances of Xuchangqing.

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39. Surface Modification on Ultra High Molecular Weight Polyethylene Scaffold with Silk Fibroin

Jun Zhu, Jiejun Cheng, Juan Zhou, Gang Huang, Dannong He

Medicine Research DOI: 10.21127/yaoyimr20190006
预出版日期: 2019-07-18

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40. New Songorine Derivatives as Novel G Protein-Coupled Receptor Antagonists: Syntheses and Preliminary Bioactivities Assay

Jiangming Wang, Ruihua Guo

Medicine Research 2019, 3 (1): 190003-. DOI: 10.21127/yaoyimr20190003

摘要（226）

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In our early screening process, songorine isolated from Aconitum brachypodum diels possessed prominent activity of inhibiting class B G protein-coupled receptors (GPCRs). For further study, a series of ester and carbonyl derivatives were synthesized and their potential inhibitory activities on class B GPCRs were also assayed by the Double Antibody Sandwich ELISA (DAS-ELISA) in vitro. Moreover, the structure-activity relationships (SARs) of songorine derivatives were discussed in detail. In this paper, the story behind this study was described.

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